Cámaras trampa y huemules: ¿Una alternativa de monitoreo?
In: Anales del Instituto de la Patagonia, Band 44, Heft 3, S. 71-76
ISSN: 0718-686X
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In: Anales del Instituto de la Patagonia, Band 44, Heft 3, S. 71-76
ISSN: 0718-686X
This paper describes the development of an innovative optimizer component as part of a calculation tool for evaluating and comparing a set of retrofitting options for domestic heating and cooling systems. At the initial stage of the process, a filtering sub-module has been developed to pre-process the information introduced by the user and generate a limited set of simulations, thus speeding up the calculation process. At a later stage, the optimizer collects and post-processes outputs from the simulation core before displaying them as a result. In this later stage, a series of performance indicators are calculated and an analytical hierarchical process (AHP) is performed to rank the results based on the user's prioritization weighting for each key performance indicator. As the main outcome of this contribution, the benefits of implementing this optimizer are evaluated in increasing the efficiency of the rest of the components of the tool and, consequently, of the overall calculation process. ; This study has been developed within the HEAT4COOL research project. This project has received funding from the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No 723925. This document reflects only the authors' view and the Commission is not responsible for any use that may be made of the information it contains. The work has also been supported by the Swiss State Secretariat for Education, Research and Innovation (SERI) under Contract No. 16.0082.
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The COVID-19 pandemic has evidenced the chronic inequality that exists between populations and communities as regards global healthcare. Vaccination, an appropriate tool for the prevention of infection, should be guaranteed by means of proportionate interventions to defeat such inequality in populations and communities affected by a higher risk of infection. Equitable criteria of justice should be identified and applied with respect to access to vaccination and to the order in which it should be administered. This article analyzes, as regards the worldwide distribution of anti-COVID-19 vaccines, the various ways the principle of equity has been construed and applied or even overlooked. The main obstacle to equal access to vaccines is vaccine nationalism. The perception of equity varies with the differing reference values adopted. Adequate response to needs appears to be the principal rule for achieving the criterion of equity in line with distributive justice. Priorities must be set equitably based on rational parameters in accordance with current needs. The entire process must be governed by transparency, from parameter identification to implementation. The issue of equal access to vaccination affects the entire world population, necessitating specific protective interventions. In light of this, the World Health Organization (WHO) has devised the COVAX plan to ensure that even the poorest nations of the world receive the vaccine; certain initiatives are also supported by the European Union (EU). This pandemic has brought to the fore the need to build a culture of equitable relationships both in each country's own domain and with the rest of the world.
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In: Libres cours 7
En revisitant l'histoire d'Européens contraints au mouvement, ce livre enquête sur le phénomène de l'exil dans un continent marqué dès le XIXe siècle par d'intenses circulations de proscrits. Sans vouloir comparer terme à terme le passé et le présent, cet ouvrage éclaire d'autres crises de l'asile liées aux exilés et réfugiés que l'Europe a connues après la fin des guerres napoléoniennes et jusqu'à la fin du XIXe siècle. Qui furent ces hommes, mais aussi, dans leur sillage, ces femmes et ces enfants contraints de quitter leur patrie? Comment l'exil, de phénomène élitiste qu'il était, est devenu une expérience socialement moins sélective au fil du siècle? Quelles ont été les réactions alors apportées par les Etats et la société civile à l'accueil des réfugiés? Telles sont les questions auxquelles ce livre veut répondre, en éclairant la façon dont les exilés du siècle des révolutions ont inventé et pratiqué des formes d'engagement alternatif qui permettent aussi d'éclairer notre présent.
In: Journal of research on adolescence, Band 31, Heft 3, S. 820-835
ISSN: 1532-7795
Members of the Society for Research on Adolescents COVID‐19 Response Team offer this commentary to accompany this special issue of the Journal of Research on Adolescence regarding the impact of the pandemic on adolescents' social, emotional, and academic functioning. In addition to outlining the critical need for scholarly collaboration to address the global impact of this crisis on adolescent development, we argue that a broad investigative lens is needed to guide research and recovery efforts targeting youth development. We then use this broad lens to consider dimensions of the pandemic impact relative to developmental implications within community and policy contexts, educational contexts, social contexts, and family contexts. Finally, we describe guideposts for setting a global, shared research agenda that can hasten research to recovery efforts surrounding the pandemic and youth development.
The COVID-19 epidemic has had a profound impact on healthcare systems worldwide. The number of infections in nursing homes for the elderly particularly is significantly high, with a high mortality rate as a result. In order to contain infection risks for both residents and employees of such facilities, the Italian government passed emergency legislation during the initial stages of the pandemic to restrict outside visitor access. On 30 November 2020, the Italian President of the Council of Ministers issued a new decree recognizing the social and emotional value of visits to patients from family and friends. In addition, it indicated prevention measures for the purposes of containing the infection risk within nursing homes for the elderly. This article comments on these new legislative provisions from the medicolegal perspective, providing indications that can be used in clinical practice.
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In: The international journal of social psychiatry, Band 68, Heft 3, S. 514-524
ISSN: 1741-2854
Background:According to the WHO, detainees attempt suicide ten times more than the general population.Aims:To investigate the impact of migration trauma on Suicidal and Self-Harm Behaviours (SSHB) of migrants in jail and to explore how substance use and other psychiatric features affect this relationship.Methods:Prospective cohort study, conducted at the 'Sant'Anna' jail in Modena (Italy) between February 2017 and September 2019. Socio-demographic, psychiatric features and records of previous SSHB were collected. Experience of migration-related trauma was assessed with the LiMEs (List of Migration Experiences) checklist. Participants were followed-up for the occurrence of further SSHB. Survival analysis was performed and Cox's Hazard Ratios (HR) were used as a measure of association of comparisons.Results:Amongst the 112 subjects (96% male, median age 33), the prevalence of any mental disorder was 26% and of substance abuse 59%. History of SSHB was present in 36% of the sample. Median follow-up time was 80 days. During follow-up, 11 events were observed (of which three were suicide attempts). Cumulative survival probability was 85%. Having experienced trauma related to war and violence was significantly associated with SSHB, HR: 7.05. No SSHB were recorded amongst subjects without substance abuse.Conclusions:Migrants in custody who experienced trauma in the post-migration period, attempt SSHB seven times more frequently than those without traumas at any time. War trauma and post-migration trauma due to exposure to violence seem to be more strongly associated with SSHB, also controlling for psychiatric diagnosis, ongoing psychopharmacological therapy and substance abuse. Further research and possible intervention programs should focus on addressing post-migration living-difficulties.
© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). ; The emergence of multidrug-resistant Mycobacterium tuberculosis (Mtb) strains highlights the need to develop more efficacious and potent drugs. However, this goal is dependent on a comprehensive understanding of Mtb virulence protein effectors at the molecular level. Here, we used a post-expression cysteine (Cys)-to-dehydrolanine (Dha) chemical editing strategy to identify a water-mediated motif that modulates accessibility of the protein tyrosine phosphatase A (PtpA) catalytic pocket. Importantly, this water-mediated Cys-Cys non-covalent motif is also present in the phosphatase SptpA from Staphylococcus aureus, which suggests a potentially preserved structural feature among bacterial tyrosine phosphatases. The identification of this structural water provides insight into the known resistance of Mtb PtpA to the oxidative conditions that prevail within an infected host macrophage. This strategy could be applied to extend the understanding of the dynamics and function(s) of proteins in their native state and ultimately aid in the design of small-molecule modulators. ; We thank CNPq Brazil (fellowship 200456/2015-6 to J.B.B. and grants 454507/2014-3 and 300606/2010-9 to H.T.), the Fundação para a Ciência e a Tecnologia (FCT Investigator award IF/00624/2015 to G.J.L.B.), the European Union (Marie-Sklodowska Curie Innovative Training Network Protein Conjugates; Marie Skłodowska-Curie Individual Fellowship 743640 to T.R.; Marie-Curie Intra-European Fellowship 626890 to O.B.), the Ministerio de Economía, Industria, y Competitividad (project CTQ2015-67727-R to F.C.), and the Biotechnology and Biological Sciences Research Council (PhD studentship to L.D.) for funding. G.J.L.B. is a Royal Society University Research Fellow and the recipient of a European Research Council Starting Grant (TagIt, 676832). We also acknowledge funding by LISBOA-01-0145-FEDER-007391, co-financed ...
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The emergence of multidrug-resistant Mycobacterium tuberculosis (Mtb) strains highlights the need to develop more efficacious and potent drugs. However, this goal is dependent on a comprehensive understanding of Mtb virulence protein effectors at the molecular level. Here, we used a post-expression cysteine (Cys)-to-dehydrolanine (Dha) chemical editing strategy to identify a water-mediated motif that modulates accessibility of the protein tyrosine phosphatase A (PtpA) catalytic pocket. Importantly, this water-mediated Cys-Cys non-covalent motif is also present in the phosphatase SptpA from Staphylococcus aureus, which suggests a potentially preserved structural feature among bacterial tyrosine phosphatases. The identification of this structural water provides insight into the known resistance of Mtb PtpA to the oxidative conditions that prevail within an infected host macrophage. This strategy could be applied to extend the understanding of the dynamics and function(s) of proteins in their native state and ultimately aid in the design of small-molecule modulators. ; e thank CNPq Brazil (fellowship 200456/2015-6 to J.B.B. and grants 454507/2014-3 and 300606/2010-9 to H.T.), the Fundação para a Ciência e a Tecnologia (FCT Investigator award IF/00624/2015 to G.J.L.B.), the European Union (Marie-Sklodowska Curie Innovative Training Network Protein Conjugates; Marie Skłodowska-Curie Individual Fellowship 743640 to T.R.; Marie-Curie Intra-European Fellowship 626890 to O.B.), the Ministerio de Economía, Industria, y Competitividad (project CTQ2015-67727-R to F.C.), and the Biotechnology and Biological Sciences Research Council (PhD studentship to L.D.) for funding. G.J.L.B. is a Royal Society University Research Fellow and the recipient of a European Research Council Starting Grant (TagIt, 676832 ). We also acknowledge funding by LISBOA-01-0145-FEDER-007391, co-financed by FEDER through the Programa Operacional Regional de Lisboa (Lisboa 2020) of PORTUGAL 2020 and by FCT Portugal.
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Studies on exile in the 19th century tend to be restricted to national histories. This volume is the first to offer a broader view by looking at French, Italian, Hungarian, Polish, Czech and German political refugees who fled to England after the European revolutions of 1848/49. The contributors examine various aspects of their lives in exile such as their opportunities for political activities, the forms of political cooperation that existed between exiles from different European countries on the one hand and with organizations and politicians in England on the other and, finally, the attitude of the host country towards the refugees, and their perceptions of the country which had granted them asylum
In: https://www.repository.cam.ac.uk/handle/1810/247876
This is the author accepted manuscript. The final version is avialble via PNAS at http://www.pnas.org/content/112/16/E1994.long#ack-1. ; We describe the isolation and detailed structural characterization of stable toxic oligomers of α-synuclein that have accumulated during the process of amyloid formation. Our approach has allowed us to identify distinct subgroups of oligomers and to probe their molecular architectures by using cryo-electron microscopy (cryoEM) image reconstruction techniques. Although the oligomers exist in a range of sizes, with different extents and nature of β-sheet content and exposed hydrophobicity, they all possess a hollow cylindrical architecture with similarities to certain types of amyloid fibril, suggesting that the accumulation of at least some forms of amyloid oligomers is likely to be a consequence of very slow rates of rearrangement of their β-sheet structures. Our findings reveal the inherent multiplicity of the process of protein misfolding and the key role the β-sheet geometry acquired in the early stages of the self-assembly process plays in dictating the kinetic stability and the pathological nature of individual oligomeric species. ; We thank Dr. Katherine Stott, from the Biophysics Facility, Department of Biochemistry, University of Cambridge, for her assistance in using these facilities. This work was supported by the Agency for Science, Technology and Research, Singapore (S.W.C.), the "La Caixa" foundation (S.D.), Wellcome/MRC (Medical Research Council) Parkinson's Disease Consortium Grant WT089698 (to E.D. and N.W.W.), National Institute for Health Research Biomedical Research Centres funding at University College London (to N.W.W.), the BBSRC through Grants BB/H003843/1 (to M.O.) and BB/E019927/1 (to C.M.D.), the Spanish Ministry of Economy and Competitiveness through Grants SAF 2012-39720 (to C.R.), BFU2013-44202 (to J.M.V.), and BIO2011-28941-C03-03 (to C.A. and G.R.), the Spanish Ministry of Health with cofunding by The European Regional Development Fund through Grant CP10/00527 (to C.R.), the Madrid Regional Government through Grant S2013/MIT-2807 (to J.M.V.), Parkinson's UK through Grant H-0903 (to T.G.), the Wellcome Trust, the Leverhulme Trust, the European Commission through project LSHM-CT-2006-037525 (to C.M.D.), the Medical Research Council through Grant MRC G1002272 (to E.J.D.-G. and C.M.D.), and the Engineering and Physical Sciences Research Council (C.M.D.). A.Y.A. was a Parkinson's UK Senior Research Fellow. N.C. is a Royal Society Research Fellow and also acknowledges financial support by the Human Frontier Science Program from Long-Term Fellowship LT000795/2009.
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12 pags, 3 figs. -- The Supporting Information is available free of charge on the ACS Publications website at DOI:10.1021/acschembio.8b00466. ; The aggregation of α-synuclein, an intrinsically disordered protein that is highly abundant in neurons, is closely associated with the onset and progression of Parkinson's disease. We have shown previously that the aminosterol squalamine can inhibit the lipid induced initiation process in the aggregation of α-synuclein, and we report here that the related compound trodusquemine is capable of inhibiting not only this process but also the fibril-dependent secondary pathways in the aggregation reaction. We further demonstrate that trodusquemine can effectively suppress the toxicity of α-synuclein oligomers in neuronal cells, and that its administration, even after the initial growth phase, leads to a dramatic reduction in the number of α-synuclein inclusions in a Caenorhabditis elegans model of Parkinson's disease, eliminates the related muscle paralysis, and increases lifespan. On the basis of these findings, we show that trodusquemine is able to inhibit multiple events in the aggregation process of α-synuclein and hence to provide important information about the link between such events and neurodegeneration, as it is initiated and progresses. Particularly in the light of the previously reported ability of trodusquemine to cross the blood-brain barrier and to promote tissue regeneration, the present results suggest that this compound has the potential to be an important therapeutic candidate for Parkinson's disease and related disorders. ; This work was supported by the Boehringer Ingelheim Fonds (P.F.), the Studienstiftung des Deutschen Volkes (P.F.), Gates Cambridge Scholarships (R.L. and G.T.H) and a St. John's College Benefactors' Scholarship (R.L.), the UK Biotechnology and Biochemical Sciences Research Council (M.V. and C.M.D.), a Senior Research Fellowship award from the Alzheimer's Society, UK, grant number (317, AS-SF-16-003) (F.A.A.), the Wellcome Trust (C.M.D., M.V., and T.P.J.K.), the Frances and Augustus Newman Foundation (T.P.J.K.), the Regione Toscana—FAS Salute—Supremal project (R.C., C.C., and F.C.), a Marie Skłodowska-Curie Actions—Individual Fellowship (C.G.), Sidney Sussex College Cambridge (G.M.), the Spanish Government—MINECO (N.C.), and by the Cambridge Centre for Misfolding Diseases (M.P., P.F., R.L., F.A.A., C.G., G.T.H., S.W.C., J.R.K., T.P.J.K., M.V., and C.M.D).
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Este libro nació en una conversación entre los editores unas semanas antes del 2 de octubre del 2016, día en que el Acuerdo de Paz de La Habana fue sometido a plebiscito. Como muchos colombianos, nos enfrascamos en una discusión sobre diversos aspectos de lo pactado por el gobierno colombiano y las Fuerzas Armadas Revolucionarias de Colombia –farc–. Esta inquietud de dos personas se transformó en un diálogo de veintitrés. Así, esta obra es una contribución de la Facultad de Jurisprudencia de la Universidad del Rosario al debate del fin del conflicto armado y la construcción de paz en Colombia. En él, participan profesores de esta y otras universidades colombianas con el fin de presentar una reflexión académica desde los estudios socio-jurídicos de los alcances, limitaciones y oportunidades de aprendizaje del proceso de paz y acuerdo logrado en 2016 con las farc. En este contexto, este libro responde a la necesidad de promover una discusión informada sobre el papel del derecho y de los abogados en la estructuración e implementación de iniciativas de paz. Luego de tantos años en que los académicos han estudiado en el país la interacción conflicto armado y derecho, es esencial dar paso a una reflexión profunda que concatene esta disciplina con los escenarios de paz. Consulte en acceso abierto la Introducción y el capítulo 7. ; This book is the outcome of a conversation between its editors several weeks before October 2, 2016, the date on which the Colombian people were to vote whether to approve the Havana Peace Agreement. Like many Colombians, we discussed different aspects and challenges of the agreement between the Colombian Government and the Revolutionary Armed Forces of Colombia –farc–. This conversation between two people soon became a dialogue among twenty-three authors. This volume is a contribution of Universidad del Rosario's Law School to the ongoing debate around the end of the armed conflict and peacebuilding in Colombia. Professors from Universidad del Rosario and other Colombian universities shared their articles to offer insights from the socio-legal perspective to the debate on the Peace Agreement's advantages and disadvantages, and lessons learned in this process. In this context, this work aims at promoting an informed discussion on the role of the law and lawyers in designing and implementing peace initiatives. After many years in which scholars have devoted their research to understand the interplay between the internal armed conflict and the law, it is time to begin an in-depth analysis of the interaction between the law and post-conflict scenarios. ; Partes de libro disponibles en acceso abierto: Agradecimientos. -- Introducción / Lina M. Céspedes-Báez, Enrique Prieto-Rios. -- Derecho de la inversión extranjera y acuerdos de paz: tensiones y soluciones / René Urueña, Enrique Prieto-Rios.
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Este libro nació en una conversación entre los editores unas semanas antes del 2 de octubre del 2016, día en que el Acuerdo de Paz de la Habana fue sometido a plebiscito. Como muchos colombianos, nos enfrascamos en una discusión sobre diversos aspectos de lo pactado por el gobierno colombiano y las Fuerzas Armadas Revolucionarias de Colombia —FARC—. Esta inquietud de dos personas se transformó en un diálogo de veintitrés. Así, esta obra es una contribución de la Facultad de Jurisprudencia de la Universidad del Rosario al debate del fin del conflicto armado y la construcción de paz en Colombia. En él, participan profesores de esta y otras universidades colombianas con el fin de presentar una reflexión académica desde los estudios socio-jurídicos de los alcances, limitaciones y oportunidades de aprendizaje del proceso de paz y acuerdo logrado en 2016 con las FARC. En este contexto, este libro responde a la necesidad de promover una discusión informada sobre el papel del derecho y de los abogados en la estructuración e implementación de iniciativas de paz. Luego de tantos años en que los académicos han estudiado en el país la interacción conflicto armado y derecho, es esencial dar paso a una reflexión profunda que concatene esta disciplina con los escenarios de paz. ; This book is the outcome of a conversation between its editors several weeks before October 2, 2016, the date on which the Colombian people were to vote whether to approve the Havana Peace Agreement. Like many Colombians, we discussed different aspects and challenges of the agreement between the Colombian Government and the Revolutionary Armed Forces of Colombia –farc–. This conversation between two people soon became a dialogue among twenty-three authors. This volume is a contribution of Universidad del Rosario's Law School to the ongoing debate around the end of the armed conflict and peacebuilding in Colombia. Professors from Universidad del Rosario and other Colombian universities shared their articles to offer insights from the socio-legal perspective to the debate on the Peace Agreement's advantages and disadvantages, and lessons learned in this process. In this context, this work aims at promoting an informed discussion on the role of the law and lawyers in designing and implementing peace initiatives. After many years in which scholars have devoted their research to understand the interplay between the internal armed conflict and the law, it is time to begin an in-depth analysis of the interaction between the law and post-conflict scenarios.
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Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9·1%] of 4521 in light restrictions, 317 [10·4%] of 3646 in moderate lockdowns, 2001 [23·8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long-term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
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