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Despite multimodal treatment, long term outcome for patients with Ewing sarcoma is still poor. The second "European interdisciplinary Ewing sarcoma research summit" assembled a large group of scientific experts in the field to discuss their latest unpublished findings on the way to the identification of novel therapeutic targets and strategies. Ewing sarcoma is characterized by a quiet genome with presence of an EWSR1-ETS gene rearrangement as the only and defining genetic aberration. RNA-sequencing of recently described Ewing-like sarcomas with variant translocations identified them as biologically distinct diseases. Various presentations adressed mechanisms of EWS-ETS fusion protein activities with a focus on EWS-FLI1. Data were presented shedding light on the molecular underpinnings of genetic permissiveness to this disease uncovering interaction of EWS-FLI1 with recently discovered susceptibility loci. Epigenetic context as a consequence of the interaction between the oncoprotein, cell type, developmental stage, and tissue microenvironment emerged as dominant theme in the discussion of the molecular pathogenesis and inter- and intra-tumor heterogeneity of Ewing sarcoma, and the difficulty to generate animal models faithfully recapitulating the human disease. The problem of preclinical development of biologically targeted therapeutics was discussed and promising perspectives were offered from the study of novel in vitro models. Finally, it was concluded that in order to facilitate rapid pre-clinical and clinical development of novel therapies in Ewing sarcoma, the community needs a platform to maintain knowledge of unpublished results, systems and models used in drug testing and to continue the open dialogue initiated at the first two Ewing sarcoma summits. ; We thank Anirah Amber and Nuno Andrade for excellent organization of the meeting. The conference was supported by the European Union's Seventh Framework Programme grants 261743(ENCCA) and 259348 (ASSET). ; Sí

6 pags.; 4 figs.; This is an open access article under the CC BY license. Funded by SCOAP ; © 2015 The Authors. The β decays Mn68→Fe68, Mn69→Fe69 and Mn70→Fe70 have been measured at the RIBF facility at RIKEN using the EURICA γ spectrometer combined with an active stopper consisting of a stack of Si detectors. The nuclei were produced as fission fragments from a beam of 238U at a bombarding energy of 345 MeV/nucleon impinging on a Be target and selected using the BigRIPS separator. Half-lives and β-delayed neutron emission probabilities have been extracted for these decays, together with first experimental information on excited states populated in 69,70Fe. The data indicate a continuously increasing deformation for Fe isotopes up to A=70. This is interpreted, as for Cr isotopes, in terms of the interplay between the quadrupole correlations of the ν1d5/2 and ν0g9/2 orbitals and the monopole component of the π0f7/2-ν0f5/2 interaction. ; The project is co-financed by the European Union and the European Social Fund. This work was supported by NuPNET-ERANET within the NuPNET GANAS project, under grant agreement No. 202914 and from the European Union, within the 7th Framework Program FP7/2007-2013, under grant agreement No. 262010 ENSAR-INDESYS. This work was also supported by Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale (PRIN) number 2001024324_01302. We here acknowledge support from the Spanish Ministerio de Ciencia e Innovación under Contracts No. FPA2009-13377-C02 and No. FPA2011-29854-C04, the Hungarian Research Fund OTKA contract numbers K100835 and NN104543, the European Commission through the Marie Curie Actions Contract No. PIEFGA-2001-30096 and by Japanese JSPS KAKENHI Grants No. 24740188 and No. 25247045. ; Peer Reviewed

We present the Global Rapid Advanced Network Devoted to the Multi-messenger Addicts (GRANDMA). The network consists of 21 telescopes with both photometric and spectroscopic facilities. They are connected together thanks to a dedicated infrastructure. The network aims at coordinating the observations of large sky position estimates of transient events to enhance their follow-up and reduce the delay between the initial detection and optical confirmation. The GRANDMA programme mainly focuses on follow-up of gravitational-wave alerts to find and characterize the electromagnetic counterpart during the third observational campaign of the Advanced LIGO and Advanced Virgo detectors. But it allows for follow-up of any transient alerts involving neutrinos or gamma-ray bursts, even those with poor spatial localization. We present the different facilities, tools, and methods we developed for this network and show its efficiency using observations of LIGO/Virgo S190425z, a binary neutron star merger candidate.We furthermore report on allGRANDMAfollow-up observations performed during the first six months of the LIGO-Virgo observational campaign, and we derive constraints on the kilonova properties assuming that the events' locations were imaged by our telescopes. © 2019 The Author(s). ; Parts of this research were conducted by the Australian Research Council Centre of Excellence for Gravitational Wave Discovery (OzGrav), through project number CE170100004. EJH acknowledges support from a Australian Research Council DECRA Fellowship (DE170100891). AdUP and CCT acknowledge support from Ramon y Cajal fellowships RyC-2012-09975 and RyC-201209984 and the Spanish Ministry of Economy and Competitiveness through project AYA2017-89384-P. DAK acknowledges support from the Spanish research projectAYA2017-89384-P. MBacknowledges funding as `personal tecnico de apoyo' under fellowship number PTA2016-13192-I. MC is supported by the David and Ellen Lee Postdoctoral Fellowship at the California Institute of Technology. SA is supported by the CNES Postdoctoral Fellowship at Laboratoire AstroParticule et Cosmologie. SA, AC, CL, and RM acknowledge the financial support of the UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02). SA and NL acknowledge the financial support of the Programme National Hautes Energies (PNHE). DT acknowledges the financial support of the Chinese Academy of Sciences (CAS) PIFI post-doctoral fellowship program (program C). UBAI acknowledges support from the Ministry of Innovative Development through projects FA-Atech-2018-392 and VA-FAF-2-010. IRiS has been carried out thanks to the support of the OCEVU Labex (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02) funded by the 'Investissements d'Avenir' French government program. IRiS and T120 thank all the Observatoire de Haute-Provence staff for the permanent support. SB, NK, RN, and MV acknowledge the Shota Rustaveli National Science Foundation (SRNSF grant No 218070). TAROT has been built with the support of the Institut National des Sciences de l'Univers, CNRS,France. TAROT is funded by theCNESand thanks the help of the technical staff of the Observatoire de Haute Provence, OSU-Pytheas.