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The cell biology behind the oncogenic PIP3 lipids
The different mechanisms of phosphoinositide 3-kinase (PI3K) activation in cancer as well as the events that result in PI3K pathway reactivation after patient treatment with PI3K inhibitors was discussed on October 15–17th, 2018, in the medieval town of Baeza (Universidad Internacional de Andalucía, Spain) at the workshop entitled 'The cell biology behind the oncogenic PIP3 lipids'. These topics and the data presented regarding cellular functions altered by PI3K deregulation, the cooperation of PI3K/PTEN mutations with other tumor drivers, and the lessons learned for PI3K-targeted therapy, are discussed below. ; Work in the group of ACC is financed by grants from the Ministerio de Ciencia e Innovación (Spanish Ministry of Science and Innovation; SAF2016-79195), the Madrid regional government (BMD-3804), the Fundación Ramón Areces and the Fundación Científica Asociación Española Contra el Cáncer (16035CARR).
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The Importance of Feminist Critique for Contemporary Cell Biology
In: Hypatia: a journal of feminist philosophy, Band 3, Heft 1, S. 61-76
ISSN: 1527-2001
Biology is seen not merely as a privileged oppressor of women but as a co-victim of masculinist social assumptions. We see feminist critique as one of the normative controls that any scientist must perform whenever analyzing data, and we seek to demonstrate what has happened when this control has not been utilized. Narratives of fertilization and sex determination traditionally have been modeled on the cultural patterns of male/female interaction, leading to gender associations being placed on cells and their components. We also find that when gender biases are controlled, new perceptions of these intracellular and extracellular relationships emerge.
Case studies in mathematical modeling - ecology, physiology, and cell biology
In: A Pearson Education print on demand edition
Systems modelling and the development of coherent understanding of cell biology
In: International Journal of Science Education, Band 30, Heft 4, S. 543-568
This article reports on educational design research concerning a learning and teaching strategy for cell biology in upper-secondary education, introducing systems modelling as a key competence. The strategy consists of four modelling phases in which students subsequently develop models of free-living cells, a general 2-D model of cells, a 3-D model of plant cells and finally they are engaged in formal thinking by modelling life phenomena to a hierarchical systems model.
The strategy was thought out, elaborated and tested in classrooms in several research cycles. Throughout the field-tests, research data were collected by means of classroom observations, interviews, audio-taped discussions, completed worksheets, written tests and questionnaires. Reflection on the research findings eventuated in reshaping and formalizing the learning and teaching strategy, which is presented here. The results show that although acquiring systems thinking competence at the metacognitive level needs more effort, our strategy contributed to improving learning outcomes, i.e. acquisition of a coherent conceptual understanding of cell biology and acquisition of initial systems thinking competence, with modelling being the key activity.
T-Cell Biology in Aging, With a Focus on Lung Disease
In: The journals of gerontology. Series A, Biological sciences, medical sciences, Band 67A, Heft 3, S. 254-263
ISSN: 1758-535X
Political advocacy by the American Society for Cell Biology and its partners
I trace how the American Society for Cell Biology became a strong political advocate for the scientific community. I celebrate how good leadership and an effective staff enabled its energetic volunteer organization to have an impact, but I also ask how the effort can be made more successful.
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Germ line stem cell biology: Lessons from the drosophila (ZPG) gene
In: Journal of the Society for Gynecologic Investigation: official publication of the Society for Gynecologic Investigation, Band 5, Heft 1, S. 54A-54A
ISSN: 1556-7117
'Hearts and bones': the ups and downs of 'plasticity' in stem cell biology
More than a decade ago, 'plasticity' suddenly became a 'fashionable' topic with overemphasized implications for regenerative medicine. The concept of 'plasticity' is supported by old transplantation work, at least for embryonic cells, and metaplasia is a classic example of plasticity observed in patients. Nevertheless, the publication of a series of papers showing rare conversion of a given cell type into another unrelated cell raised the possibility of using any unaffected tissue to create at will new cells to replace a different failing tissue or organ. This resulted in disingenuous interpretations and a reason not to fund anymore research on embryonic stem cells (ESc). Moreover, many papers on plasticity were difficult to reproduce and thus questioned; raising issues about plasticity as a technical artefact or a consequence of rare spontaneous cells fusion. More recently, reprogramming adult differentiated cells to a pluripotent state (iPS) became possible, and later, one type of differentiated cell could be directly reprogrammed into another (e.g. fibroblasts into neurons) without reverting to pluripotency. Although the latter results from different and more robust experimental protocols, these phenomena also exemplify 'plasticity'. In this review, we want to place 'plasticity' in a historical perspective still taking into account ethical and political implications.
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'Hearts and bones': the ups and downs of 'plasticity' in stem cell biology
More than a decade ago, 'plasticity' suddenly became a 'fashionable' topic with overemphasized implications for regenerative medicine. The concept of 'plasticity' is supported by old transplantation work, at least for embryonic cells, and metaplasia is a classic example of plasticity observed in patients. Nevertheless, the publication of a series of papers showing rare conversion of a given cell type into another unrelated cell raised the possibility of using any unaffected tissue to create at will new cells to replace a different failing tissue or organ. This resulted in disingenuous interpretations and a reason not to fund anymore research on embryonic stem cells (ESc). Moreover, many papers on plasticity were difficult to reproduce and thus questioned; raising issues about plasticity as a technical artefact or a consequence of rare spontaneous cells fusion. More recently, reprogramming adult differentiated cells to a pluripotent state (iPS) became possible, and later, one type of differentiated cell could be directly reprogrammed into another (e.g. fibroblasts into neurons) without reverting to pluripotency. Although the latter results from different and more robust experimental protocols, these phenomena also exemplify 'plasticity'. In this review, we want to place 'plasticity' in a historical perspective still taking into account ethical and political implications.
BASE
Moving Away from Dogmatic Knowledge Dissemination in a Cell Biology Module: Examples from Singapore
In: Bioscience education electronic journal: BEE-j, Band 20, Heft 1, S. 106-115
ISSN: 1479-7860
35. Mosbacher Kolloquium der Gesellschaft für Biologische Chemie. The Impact of Gene Transfer Techniques in Eucaryotic Cell Biology
In: Hoppe-Seyler´s Zeitschrift für physiologische Chemie, Band 365, Heft 1, S. 213-222
Evaluation of Formative Computer-based Assessment by Cell Biology Students with Differing Entry Qualifications and Ethnicity
In: Bioscience education electronic journal: BEE-j, Band 8, Heft 1, S. 1-9
ISSN: 1479-7860
Large-Scale Analysis of 2,152 Dataset Reveals Key Features of B Cell Biology and the Antibody Repertoire
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Working paper
Collaborative learning experiences and development of capabilities among first-year pre-service teachers learning Cell Biology concepts
In: Social sciences & humanities open, Band 5, Heft 1, S. 100254
ISSN: 2590-2911