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This study focuses on the extrinsic factors, namely, top management support, complexity, independence, and internal audit department’s size that are out of internal auditors' control affecting their effectiveness in the Jordanian public sector. The current study also tries to improve understanding of the extrinsic factors affecting internal auditors’ ability to achieve the assigned goals in order to highlight internal auditors’ effectiveness. Resource-based and agency theories were used in developing the research model. Two sets of questionnaires were distributed among the financial managers and internal audit managers. The results reveal that top management support, independence, and the size of internal audit department play a significant and positive role on the effectiveness of internal auditors, whereas complexity of the task has been found to make a negative impact on the level of their performance. Given the significance of the public sector within the Jordanian economy, the findings are valuable for the internal audit function, regulators, and decision-makers in proposing new legislation and regulations of an internal audit function. Future studies may look into other factors that may restrict internal audit performance, such as organizational culture and pay satisfaction.

The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes ; The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB. ; HN-B acknowledges the receipt of research scholarships from Bolsa D. Manuel de Mello and the Portuguese Society for Pneumology. NO acknowledges FCT IF/00474/2014. SG is funded by the European Research Council (grant number 309540-EVODRTB); the Swiss National Science Foundation (grant number 310030_166687) SystemsX.ch. IC lab is financed by Ministerio de Economía y Competitividad (Spanish Government) research grant SAF2013-43521-R, SAF2016- 77346-R, and PROMETEO/2016/122 from Generalitat Valenciana and the European Research Council (ERC) (638553-TB-ACCELERATE). The MS lab is financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT in the framework of the project "Institute for Research and Innovation in Health Sciences" ...

The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB. ; HN-B acknowledges the receipt of research scholarships from Bolsa D. Manuel de Mello and the Portuguese Society for Pneumology. NO acknowledges FCT IF/00474/2014. SG is funded by the European Research Council (grant number 309540-EVODRTB); the Swiss National Science Foundation (grant number 310030_166687) SystemsX.ch. IC lab is financed by Ministerio de Econom?a y Competitividad (Spanish Government) research grant SAF2013-43521-R, SAF2016-77346-R, and PROMETEO/2016/122 from Generalitat Valenciana and the European Research Council (ERC) (638553-TB-ACCELERATE). The MS lab is financed by FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020-Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274). MS is an FCT Principal Investigator. Some graphical elements in the figures were designed by kjpargeter/Freepik. The funding agencies had no role in the design of the manuscript.

The already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our understanding of TB are thus needed. In particular, understanding the intricate network of events modulating inflammation in TB will help to build more effective vaccines and host-directed therapies to stop TB. This review integrates the impact of host, pathogen, and extrinsic factors on inflammation and the almost scientifically unexplored complexity emerging from the interactions between these three factors. We highlight the exciting data showing a contribution of this troika for the clinical outcome of TB and the need of incorporating it when developing novel strategies to rewire the immune response in TB. ; HN-B acknowledges the receipt of research scholarships from Bolsa D. Manuel de Mello and the Portuguese Society for Pneumology. NO acknowledges FCT IF/00474/2014. SG is funded by the European Research Council (grant number 309540-EVODRTB); the Swiss National Science Foundation (grant number 310030_166687) SystemsX.ch. IC lab is financed by Ministerio de Economía y Competitividad (Spanish Government) research grant SAF2013-43521-R, SAF2016-77346-R, and PROMETEO/2016/122 from Generalitat Valenciana and the European Research Council (ERC) (638553-TB-ACCELERATE). The MS lab is financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT in the framework of the project "Institute for Research and Innovation in Health Sciences" (POCI-01-0145-FEDER-007274). MS is an FCT Principal Investigator. Some graphical elements in the figures were designed by kjpargeter/Freepik. The funding agencies had no role in the design of the manuscript. ; Peer reviewed

Diverse factors provide indicators of job motivation challenges amongst healthcare workers. These factors include the high level of employee turnover. For example, in 2017, an estimated 700 doctors quit employment in government-run hospitals. Additionally, the Kenya Medical Practitioners and Dentist Union (KMPDU) estimated that up to 2,300 doctors had left devolved sector employment between 2014 and 2016 for private sector engagement or further education abroad. Moreover, the various groups of healthcare workers including doctors, nurses, and clinical officers have held numerous industrial strikes against their employers. Consequently, this study seeks to study the factors influencing job motivation in the healthcare public sector. The study is based on Herzberg's 2-factor theory that splits factors affecting employee job motivation as extrinsic and motivating factors. The study used a descriptive research design and the target population was health workers in Nakuru County Public health facilities including doctors, clinical officers, laboratory technicians, pharmacists and nurses. The study population was 1756 respondents. The sample size of this study, using Taro Yamane's (1967) formula, was 326 respondents. The correlation between diverse factors and job motivation was examined. The study found a strong positive correlation between extrinsic factors and job motivation (r = 0.633, p value = 0.000). The regression analysis results revealed that a unit increase in extrinsic factors is associated with a 0.318 increase in job motivation levels. Article visualizations:

Tags, and their deployments, were funded by the Welsh Assembly Government (Welsh colonies; project no. JER3688), Marine Scotland (Stroma and Muckle Green Holm; project no. CR/2009/48), the Natural Environment Research Council (NERC) (Isle of May) and SMRU Instrumentation (Isle of May). MIDC studentship is co-funded by Plymouth University School of Biological & Marine Sciences and NERC. DJFR, CJB & DT are supported by National Capability funding from NERC to SMRU (grant no. SMRU1001). ; Young animals must learn to forage effectively to survive the transition from parental provisioning to independent feeding. Rapid development of successful foraging strategies is particularly important for capital breeders that do not receive parental guidance after weaning. The intrinsic and extrinsic drivers of variation in ontogeny of foraging are poorly understood for many species. Grey seals (Halichoerus grypus) are typical capital breeders; pups are abandoned on the natal site after a brief suckling phase, and must develop foraging skills without external input. We collected location and dive data from recently-weaned grey seal pups from two regions of the United Kingdom (the North Sea and the Celtic and Irish Seas) using animal-borne telemetry devices during their first months of independence at sea. Dive duration, depth, bottom time, and benthic diving increased over the first 40 days. The shape and magnitude of changes differed between regions. Females consistently had longer bottom times, and in the Celtic and Irish Seas they used shallower water than males. Regional sex differences suggest that extrinsic factors, such as water depth, contribute to behavioural sexual segregation. We recommend that conservation strategies consider movements of young naïve animals in addition to those of adults to account for developmental behavioural changes. ; Publisher PDF ; Peer reviewed

7‐11 November 2010, Tenth International Congress on Drug Therapy in HIV Infection, Glasgow, UK

PURPOSE: The unprecedented academic environment brought by the COVID-19 pandemic led to the evolution of online teaching as an ineluctable tool for education and training. To ensure that the undergraduate teaching curriculum does not become another victim of the virus, online teaching was started in most medical schools. The undergraduate students enrolled in our institution hail mostly from rural areas and small townships with limited internet connectivity and accessibility due to poor socioeconomic status. This study highlights the students' perception of and motivation towards online classes in respect to internet connectivity and accessibility during COVID-19 pandemic. Since online teaching is essentially a student-centered learning approach, the motivational level of students plays an important role in making teaching protocols effective. METHODS: A prospective qualitative and quantitative assessment of perceptions of 498 medical undergraduate students from 1st, 2nd and 3rd year of Dr. Ram Manohar Lohia Institute of Medical Sciences, Vibhuti Khand, Gomti Nagar, Lucknow, Uttar Pradesh, India was done using validated online questionnaires and anonymous voluntary feedback during the government-imposed lockdown from March 2020 to November 2020. RESULTS: On evaluation of 260 responses received, it was found that the majority of students were motivated to attend the online classes but external factors like internet connectivity and household environment were affecting their motivation on a daily basis and thus decreasing the motivation levels. Validity of feedback by Cronbach's alpha was 0.907 and Pearson coefficient between internet connectivity and motivation factors was 0.419 (p-value <0.001). CONCLUSION: The extrinsic factors of internet connectivity and household environment hamper the motivation of students to attend online classes; this should be considered as an important factor to enable the desired student-led learning as mandated by competency-based medical education.