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Introduction: The results of clinical trials (CT) are used by regulatory agencies around the world for the purposes of drug product's registering and marketing. The Brazilian Health Surveillance Agency (Anvisa, in Portuguese) is responsible for the registration of health technologies in Brazil and for creating the rules for the analysis of technical issues in clinical trials. Anvisa has been working to update its regulatory framework regarding clinical trials with drugs in the country, to reduce analysis time and harmonize the normative frame according to international guidelines. Objective: To characterize phase III clinical trials, with drug products, conducted in Brazil from the publication of RDC n° 9, on 20 February 2015 by Anvisa. Method: Exploratory and descriptive study, carried out in three stages: (1) quantitative analysis before and after RDC n° 9/2015; (2) analysis of the population participating in clinical trials that supported medication records; (3) characterization of the clinical trial performed in Brazil. Results: There was a 20% reduction in clinical trials conducted in Brazil when compared before and after RDC n° 9/2015 by Anvisa; only 33% of the clinical trials that supported drug product registrations in Brazil were performed with the Brazilian population; synthetic and biological drugs account for 96% of the intervention studied in clinical trials; placebo is still widely used as a comparator (37%); the pharmaceutical industry is mostly the sponsor of the clinical trial (86%). Conclusions: In view of this scenario, it is imperative to strengthen pharmacovigilance actions in Brazil, in order to learn about the effectiveness and safety profiles of medicines after exposure of the Brazilian population. ; Introdução: Os resultados de ensaios clínicos são utilizados pelas agências regulatórias de todo o mundo para fins de registro e comercialização de medicamentos. A Agência Nacional de Vigilância Sanitária (Anvisa) é a responsável pelos registros de tecnologias em saúde no Brasil e regras para análises técnicas de ensaios clínicos. A Anvisa vem atuando para atualizar seu arcabouço regulatório a respeito de ensaios clínicos com medicamentos no país, para reduzir tempo de análise e harmonizar conforme regras internacionais. Objetivo: Caracterizar os ensaios clínicos de fase III, com medicamentos, realizados no Brasil a partir da publicação da RDC n° 9, de 20 de fevereiro de 2015, da Anvisa. Método: Estudo exploratório e descritivo realizado em três etapas: (1) análise quantitativa pré e pós RDC n° 9/2015; (2) análise da população participante de ensaio clínico que embasou registros de medicamentos; (3) caracterização dos ensaios clínicos realizados no Brasil. Resultados: Houve redução em 20% de ensaios clínicos realizados no Brasil quando se compara o período anterior e posterior à publicação da RDC n° 9/2015 da Anvisa; apenas 33% dos ensaios clínicos que embasaram registros de medicamentos no país foram realizados com população brasileira; os medicamentos sintéticos e biológicos somam 96% da intervenção estudada nos ensaios clínicos; placebo ainda é muito utilizado como comparador (37%); a indústria farmacêutica é majoritariamente o patrocinador dos ensaios clínicos (86%). Conclusões: Diante deste cenário, é imperativo que se fortaleçam as ações de farmacovigilância no Brasil, a fim de conhecer os perfis de efetividade e segurança dos medicamentos após exposição da população brasileira.

Today we live in an increasingly scientific and technologically developed society that has promoted transformations in the social, political and economic environment. This development brought with it the illusion that all social and cultural problems would be solved, creating a traditional image of this science, in which its development would be free of particular interests. In order for the community to be able to understand the relations between science and the collective, it is necessary to have debates about the subject, and thinking about it, the movement called Science, Technology, Society and Environment (STSE) was created, representing a critical study group about the traditionalist and essentialist view of science and technology. The STSE studies seek to understand their social dimensions and even their consequences. Thus, this study has as main objective to review the Brazilian literature in search of articles that work the STSE approach in the teaching of Chemistry in the context of the high school classroom, with the intention of training citizens critical about the most diverse subjects of this. This research has a qualitative character, as it allows the researcher a better approximation and understanding of the facts studied. The articles were searched in national journals that allow free access and with qualis A1, A2 and B1 qualis according to the CAPES Qualis-Periodical system. In all, 24 journals were found, but only 8 articles were found with the theme under study, being found 14 in total. The selected papers cover the topics of Acids and Bases (1), Physical-Chemistry (1), Environmental Chemistry (3), Organic Chemistry (8) and Radioactivity (1), in which teaching was conceived in the STSE precepts to promote greater contextualization and the formation of the critical citizen. All the creators of the researches sought through the STSE to make the classes more attractive and dynamic, centering the construction of the knowledge in the student through the stimulation of the research.

Political education means preparing citizens to accept social roles and perform political duties in society. Wise political education is one of the educational models that is rooted in the philosophical tradition of ancient Greece and has been considered by thinkers in different historical periods. In this educational model, the institutionalization of political and social values and norms is followed in three individual, family and social areas of education. In this process, the physical and mental education of individuals begins from childhood and they are taught political and social skills and awareness on the path to development. Teaching moral virtues and avoiding moral vices is the basis of wise political education. The institution of the family has the task of institutionalizing values and norms such as love, affection, courage, friendship, cooperation and rule of law in children. And in the process, individuals are prepared to accept and play political and social roles. ; La educación política significa preparar a los ciudadanos para que acepten los roles sociales y desempeñen los deberes políticos en la sociedad. La educación política sabia es uno de los modelos educativos que hunde sus raíces en la tradición filosófica de la antigua Grecia y ha sido considerada por pensadores de diferentes periodos históricos. En este modelo educativo se sigue la institucionalización de los valores y normas políticas y sociales en tres ámbitos de la educación: individual, familiar y social. En este proceso, la educación física y mental de los individuos comienza desde la infancia y se les enseña las habilidades y la conciencia política y social en el camino del desarrollo. Enseñar las virtudes morales y evitar los vicios morales es la base de una sabia educación política. La institución de la familia tiene la tarea de institucionalizar en los niños valores y normas como el amor, el afecto, el valor, la amistad, la cooperación y el imperio de la ley. Y en el proceso, los individuos están preparados para aceptar y ...

The aim of this research is to analyze the concept of reading in the mainly official documents that subsidize the practice of readingin the school context.The work is guided on the assumptions of Applied Linguistics about reading,about dialogical conception of language and research developed in Brazil under this line.Firstofall, it ispointed out theassumptionsaboutReading showed in thenationaldocuments: Parâmetros Curriculares Nacionais do Ensino Fundamental (BRASIL, 1998) and Parâmetros Curriculares Nacionais do Ensino Médio (BRASIL, 2000); after, theideaspresentedbystatedocuments: Referencial Curricular do Ensino Fundamental das Escolas Públicas do Estado do Tocantins (TOCANTINS, 2009a) and Proposta Curricular do Ensino Médio (TOCANTINS, 2009b). The results of the documentary research show that, in general, in the official documents there is the interactive concept of reading, since reading is conceived as a process that enables dialogue between author, text and reader, contributing to the formation of the critical reader.