Impulsivity and relapse during treatment of methamphetamine use disorder
In: Sucht: Zeitschrift für Wissenschaft und Praxis, Band 65, Heft 4, S. 263-270
ISSN: 1664-2856
Abstract. Aims: The increasing prevalence of patients seeking treatment for methamphetamine use disorder (MUD) in some regions of Germany and the high relapse rates following common treatment interventions make more effective interventions highly needed. The aim of the present study was to enhance our understanding of the impact of impulsivity on relapse during treatment and thus to outline possible individual characteristics that make more tailored interventions necessary. Methodology: Forty-two patients with a diagnosis of MUD admitted to inpatient treatment and 21 matched healthy control participants (HC) completed the Barratt Impulsiveness Scale (BIS-11) as a self-reported measure of trait impulsivity and a go/no-go task with methamphetamine-associated and neutral stimuli to assess deficits of response inhibition. Relapse rates of patients during treatment were assessed. Results: Higher impairment of response inhibition, but not trait impulsivity, significantly predicted relapse during treatment. These findings were observed although patients with MUD compared to HC did not differ with regard to deficits of response inhibition. Conclusions: These findings suggest that patients with MUD who show enhanced deficits of response inhibition are more vulnerable to relapse during treatment and need more tailored treatment interventions.