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Tadeusz Robak Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz, PolandSafety of Biologics Therapy: Monoclonal Antibodies, Cytokines, Fusion Proteins, Hormones, Enzymes, Coagulation Proteins, Vaccines, Botulinum Toxins (Cham, Switzerland: Springer International Publishing; 2016) by Brian A Baldo from the Molecular Immunology Unit, Kolling Institute of Medical Research, Royal North Shore Hospital of Sydney, and the Department of Medicine, University of Sydney, Australia, is a book that belongs on the shelf of everyone in the field of biologic therapies research and clinical practice. In writing this book, the author's intention was to produce an up-to-date text book on approved biologic therapies, as far as that is possible in this time of rapidly evolving developments in biotherapeutic research and the introduction of new and novel agents for clinical use.The monograph comprises 610 pages in 13 chapters, each including a summary and further reading suggestions. All chapters include a discussion of basic and clinical material. Well-designed, comprehensive tables and color figures are present throughout the book. The book itself examines the biologic products that have regulatory approval in the USA and/or European Union and that show every indication of remaining important therapies. It covers in great detail all the latest work on peptide hormones and enzymes, monoclonal antibodies, fusion proteins, and cytokine therapies. Beyond that, it also presents the latest information on blood coagulation proteins, vaccines, botulinum neurotoxins, and biosimilars.

There is an increasing demand from the public and from legislators to treat pavement management like a business - know what you have, know what it is worth, and invest strategically. The private and public sectors, however, differ fundamentally in their purposes: the private sector aims to make and grow profits, while the public sector aims to support and improve society - financial profits and losses versus wider costs and benefits such as environmental and social impacts. Conversely, the private sector has begun to evaluate and discover the positive impacts of environmental protection and social responsibility on its profit margins. The public and private sectors have much to learn from each other. This paper explores the management principles and tools used in the private sector that should be adopted in the pavement management sphere in order to better evaluate and communicate the impacts of our investments, with the aim of enhancing our economic, social and environmental sustainability. These principles include evaluating our entire portfolio against our goals - including assessing alternative service provision mechanisms - and redirecting our investments to more 'profitable' areas. In addition to adopting private sector principles, many of our public sector principles and tools, such as pavement performance modeling and whole of life costing, should continue to play a strong role and should be further developed. This paper discusses how new and existing principles can be brought together for more sustainable and robust investment decisions - and, importantly, how they can be used to better communicate investment needs to stakeholders. ; Presented during Session 15: Data Quality and Accountability, moderated by Linda Pierce, at the 9th International Conference on Managing Pavement Assets (ICMPA9) in Alexandria, VA. ; Includes conference paper and PowerPoint slides.

The article brings up the issue of the attitude of the Polish liberal community towards integration with the European structures. Its objective is to show the attitudes, opinions and argumentation of the liberal pro-integrative option after the year 1989. In this regard, the standpoints of the following parties are analysed: Citizens' Movement for Democratic Action (ROAD), Democratic Union (UD), Liberal-Democratic Congress (KLD), Freedom Union (UW) and Civic Platform (PO). In further parts of the article, the author shows that to liberal parties Western Europe constituted a synonym of freedom, democracy, prosperity and progress. One can get an impression that this fascination was so strong that it was trusted without any critical reflections. As a result, the liberals contributed to the guiding of Poland's development, accepting the pro-western option that was maintained and consistently realised by all successive governments.

Цель: Целью публикации является представление основных параметров средств индивидуальной защиты от загрязнений (ISOPS), которые используются в Вооруженных Силах. Введение: За последние два десятилетия в Вооруженных силах Республики Польша значительно повысилось качество средств индивидуального оборудования солдат, предназначенного для защиты от загрязнений. Данное оборудование направленно прежде всего на защиту от загрязнений, вызванных оружием массового поражения (ОМП), но оно также может использоваться при других видах загрязнений. Одним из таких примеров могут быть противогазы MP-5, MP-6, в которых можно использовать комбинированные фильтры, преданаченные для разного вида опасных веществ. По очевидным причинам Вооруженные силы в мирное время проходят обучение и подготовку для обеспечения ими соответствующего уровня защиты войск и ликвидации последствий химического, биологического, радиологического и ядерного оружия (ХБРЯ). Между тем, Государственная Пожарная Служба Республики Польша (PSP) ежедневно борится с угрозами, связанными с высвобождением опасных веществ. Иногда, особенно в ситуации крупномасштабного загрязнения или если его характер превышает возможности Государственной Пожарной Службы (PSP), ожидается сотрудничество обоих субъектов. Одним из важнейших принципов сотрудничества армии и Государственной Пожарной Службы (PSP) является обеспечение безопасности спасателям участвующим в действиях, которая в значительной степени зависит от обоюдного понимания процедур, техник и вариантов оснащения обеих групп. В то же время эти факторы являются определяющими во взаимодействии, если гражданские и военные спасательные элементы рассматриваются как компоненты единой, согласованной национальной системы. Методология: В статье использован метод анализа и критики литературы, а также наблюдений. Авторы принимали за основу заводские инструкции производителей и опыт пользователей данного оборудования. Выводы: В статье было представлено современное оснащение солдат Вооруженных сил Республики Польша, которые в чрезвычайных ситуациях будут поддерживать другие исполнительные субъекты Системы Кризисного Управления страны. Основой такого сотрудничества будет взаимное понимание процедур, техник и возможностей оборудования обеих формаций, в частности возможность выполнения задач в условиях загрязнений отдельными субъектами. Из вышеприведенного следует, что во время совместного действия исполнительных субъектов кризисного реагирования в условиях загрязнений основное значение для эффективного и безопасного планирования, управления действиями а также их реализации будет иметь знание о защитных возможностях индивидуальных средств защиты участников (солдат) в сфере угроз химического, биологического, радиологического и ядерного характеров (ХБРЯ).Aim: The aim of the article is to present the essential parameters of personal protective measures against contamination, used by the Polish Armed Forces. Authors anticipate that exposed issues will improve the effective co-operation between services. Introduction: In the last two decades there was a significant qualitative leap in the provision of personal protection equipment to individual soldiers of the Polish Armed Forces. This equipment, in the main, is intended to provide protection against contamination from Weapons of Mass Destruction (WMD), but the equipment can also be used in other hazardous environments. An illustration of alternative uses may be found with MP-5 and MP-6 respirators, which allow for the use of combined filters intended for use in the presence of all kinds of hazardous substances. For obvious reasons, military formations are trained and prepared to deal with consequential hazards associated with chemical, biological, radiological and nuclear (CBRN) warfare, and to secure an appropriate level of protection for military personnel. Simultaneously, the State Fire Service (SFS) struggles on a daily basis with hazards caused by the release of dangerous toxic substances. At times, specifically during major incidents or emergencies, which exceed the capability of SFS, both the Armed Forces and SFS are expected to co-operate and mitigate the consequences of a CBRN release. One of the most important principles of inter service co-operation concerns the safety of rescue personnel, which, to a large extent, depends on mutual understanding of procedures, techniques and availability of suitable equipment to both formations. These factors impact on synergy if civilian and military rescue elements are viewed as components of a single, unified national rescue system. Method: This study contains a critical review of literature and includes outcomes from observation. In the main, the study utilized manufacturers' equipment instructions and information gained from user experience. Conclusions: The article illustrates the latest equipment available to soldiers of the Polish Army who, in exceptional circumstances, support other formations involved with National Crisis Management System operations. The basis for such co-operation will be a mutual understanding of procedures, techniques, access to suitable equipment by both organisations and, in particular, the prospect of a successful discharge of responsibility in a hazardous environment by respective entities. From the aforementioned, it may be deduced that during joint rescue operations, the critical factor for safe and effective planning, management of operations and successful outcomes will be, inter alia, awareness of personal protective equipment potential, currently made available to personnel (soldiers) engaged in CBRN hazard operations.

Great Moravian monuments have attracted special attention of both professionals and laypeople for a long time. In this paper we focus on only two of the Great Moravian sites studied at the Institute of Archaeology, Slovak Academy of Sciences (IA SAS ). One of the locations is Nitra, the former seat of Great Moravian dukes and Hungarian kings founded in 828. In the 9th century, the town was a large political and cultural centre. Relics from this period (such as remains of fortifications and sacral buildings) can be found on the castle hill and in the area of old military barracks situated in the foothills of Zobor. Unfortunately, some of the relics have been irreversibly lost due to the intense growth of the city and related construction activities. The second site is Bojna, with an agglomeration of five earth fortifications. The most significant of these is a twelve-hectare hillfort of Valy, where we have reconstructed or marked the most interesting historical constructions in situ. Here, visitors can see reconstructions of one of the gates, fragments of the impressive fortifications, and dwellings located inside the hillfort. In the village centre, they can also visit an archaeological museum. Each year, thanks to successful cooperation with local communities and representatives of municipalities, the sites and their history are revived during Nitra Days or the St. Cyril and Methodius Day.

The security of national energy systems as well as the transition to a low-carbon future are two hot topics of discussion in the international political arena. Research on the stability of centralized energy systems is currently focused on distributed generation. Developing a scalable microgrid model enabling its massive adoption is one of the safest and feasible ways to solve such problem. The paper aims to fill an existing gap regarding the operation model of microgrids that is a barrier for the large-scale integration of those in the conventional grid network. In the proposed approach the authors identified key processes to be considered when operating microgrids, in the conditions shown through an experimental (simulation) campaign. A three-phase research was performed: (1) systematic literature review to explore the management models of a stand-alone microgrid design and management ; (2) a household experiment ; and (3) a computer simulation of energy balance for a selected household. We identified eight key processes constituting a scalable microgrid: five core processes, two supporting processes, and one management process. Subsequently, we developed a map of these processes obtaining a microgrid process model for massive adoption. The model of processes can be considered as a repeatable pattern of conduct in the creation and maintenance of microgrids, which their future owners can follow. To support our literature findings, we performed an experiment and a computer simulation of three sub-processes of the (re)design of the infrastructure process: (1) wind turbine selection, (2) photovoltaic power plant selection, and (3) energy-storage selection. Results confirm conditional stability of the analyzed microgrid and the need for cyclical simulation exercises until unconditional stability is achieved. In terms of sustainability, to keep the microgrid permanently in a positive energy balance will require the implementation of all key processes.

Die Programm- und Angebotsplanung gilt als genuine erwachsenenpädagogische Tätigkeit und professionelles Handlungsfeld (Fleige, Gieseke, Hippel, Käpplinger & Robak 2018, Gieseke 2015, Kraft 2009). Anders als im schulischen Bereich, in dem Curricula Bildung vorstrukturieren, zeichnet sich die Erwachsenenbildung zumeist durch inhaltliche Offenheit ihrer Bildungsangebote aus, wodurch Bildungsange-bote und Programme vielfältiger Formen und Inhalte entstehen. "Education and training programs for adults come in all shapes, sizes, and formats." (Caffarella & Ratcliff Daffron 2013, S. 2) Bildungsangebote und Programme sind hierbei das Ergebnis von Programm- und Angebotsplanung, die durch Planende in einem komplexen Gefüge aus verschiedenen Akteuren, Interessen, Bedarfen und Bedürfnissen, politischer und regionaler Verortungen übernommen werden. Forschungsergebnisse zur Programmplanung markieren institutions- und bildungsbereichsspezifische Eigenschaften von Planungshandeln und den damit einhergehenden Entscheidungen und Begründungen (Pohlmann 2018). Sie verdeutlichen sowohl allgemeine als auch spezifische Merkmale, die nur für bestimmte Institutionen und Bildungsbereiche zutreffen. Daher sind fallbezogene Untersuchungen von Programmplanung zu intensivieren, um spezifische Elemente des Planungshandelns in Detailanalysen herauszuarbeiten (Lorenz & Pohlmann 2016). Vor allem die Programmplanung von privaten Bildungsanbietern ist bislang kaum untersucht. Sie ist entweder in institutionenübergreifenden Untersuchungen inkludiert (Dollhausen 2008, Pohlmann 2018) oder implizit anhand spezieller Formate wie eLearning miterhoben (Rippien 2012). Der vorliegende Beitrag schließt dieses Forschungsdesiderat über die fallanalytische Darstellung einer empirischen Untersuchung zur Programmplanung bei einem privaten Bildungsdienstleister der beruflichen Bildung. Aufbauend auf einer theoretischen Darstellung bisheriger Erkenntnisse zu Programmplanung, deren Modellen und Verständnissen, werden die Befunde der Fallanalyse dargestellt. Hierbei wird die Programm- und Angebotsplanung von WEITBILD, als bundesweit agierender Bildungsdienstleister der beruflichen Bildung, analysiert. Das Planungshandeln wird als arbeitsteiliger Prozess charakterisiert, der sich in einem spezialisierten, innerorganisationalen Netzwerk im Spannungsfeld von Kundensegmenten, Zentralität und Regionalität vollzieht.

PROFILBILDUNG ProfilBildung ( - ) Einband ( - ) Deckblatt ( - ) Titelblatt ( - ) Impressum ( - ) Inhalt (5) Einleitung (8) Profil und Perspektive. 25 Jahre Universität Gesamthochschule Kassel (9) Gründungs-Perspektiven ( - ) Die historische Chance. Zur Entstehungsgeschichte der Gesamthochschule in Kassel (37) Demokratie - Bildung - Hochschule. Ein Interview mit Ludwig von Friedeburg und Christoph Oehler, geführt von Annette Ulbricht-Hopf (77) Modell GhK? Die Gesamthochschule Kassel als Herausforderung an die Hochschulpolitik (95) Fach-Kulturen ( - ) Prekäre Grenzen. Zur akademischen Kultur in der GhK aus der Sicht einer neuberufenen Hochschullehrerin (109) Schlegel, Comte, Marx und der Geist der "GhK". Zur Dialektik der Versozialwissenschaftlichung einer Universität (125) Wie männlich ist das Reformmodell? Zur Entwicklung der Frauenforschung an der GhK. Ein Gespräch zwischen Anke Bohnacker, Christel Eckart, Aylâ Neusel, Brigitte Robak, Luise Schottroff, Helen Schüngel-Straumann, Heide Wunder (135) Impulse für die Region? Die Ausbildung von Ökonomen im Wandel (149) Kontinuität im Wandel. Von der OE II zu den Fachbereichen Anglistik/Romanistik und Germanistik (163) Gestalten oder nachvollziehen? Aspekte zur Entwicklung der Ingenieurwissenschaften an der GhK (179) Halbzeit. Zum Aufbau der Naturwissenschaften und der Mathematik in Forschung und Lehre (191) Der Mensch lebt nicht vom Brot allein. Ein Versuch über die Agrar- und Umweltwissenschaften an der GhK (211) Z. Die Geschichte eines ganz normalen Idioten. Die Kunst an der GhK aus der Sicht eines emeritierten Kunsthochschullehrers (225) GhK-Profile ( - ) Profil in Bewegung. Zur Studien- und Forschungsentwicklung an der GhK (245) Zwischen Exotik und Notwendigkeit. Internationalität und internationale Beziehungen der GhK (299) Auf dem Weg zur doktorvaterlosen Gesellschaft? Ein Dialog zur Situation des Wissenschaftlichen Nachwuchses an der GhK (313) Praxis großgeschrieben. Projektstudium und berufspraktische Studien am Beispiel Architektur (333) Lehre und Forschung verbinden. Erfahrungen aus einer Forschungsgruppe in der Stadt- und Landschaftsplanung (341) Wo sind sie geblieben? Kasseler Absolvent(innen)en der Wirtschaftswissenschaften im Beruf (347) Studien-Erfahrungen ( - ) Zwischen Selbsterfahrung und Selbstbildung. Lehramtsstudium an der GhK von 1977 bis 1983 (353) Unterricht als Projekt. Das Reformelement Projektstudium in der Berufsschule (361) Reiz und Gefahr der Freiheit. Ein Bericht über die Anfänge des Magisterstudiums an der GhK (365) Durchaus zu empfehlen. Studienaufbau, Interdisziplinarität und Internationalität im Wirtschaftsstudium (367) Summa summarum cum laude. Vom Studienanfänger zum wissenschaftlichen Mitarbeiter im Maschinenbau (369) Wink-Elemente? Über Verlust und Gewinn interessenorientierten Studiums in der Elektrotechnik (373) . und abends gehörste in'n Stall. Geschichten eines GhK-Studenten aus Oberhessen (377) Außen-Ansichten ( - ) "Wohin mit ihr?" Geschichte einer erfolgreichen Intrige, dazu ein paar Jubiläumsbetrachtungen (391) Kassel - eine Hochschulstadt? Kooperationen und Perspektiven von Stadt und Hochschule (403) Theorie und Praxis. Die Bedeutung der GhK für die Region Nordhessen aus der Sicht der Wirtschaft (419) Die Hochschulstadt als Labor. Zur Wechselwirkung von städtischer und universitärer Kultur (429) Transfer ist keine Einbahnstraße. Zur Wechselwirkung von Gesamthochschule und Region (445) Universität und Stadt. Zur Baugeschichte und Architektur der GhK (469) Von der Ritterschule zur modernen Universität. Eine chronologische Übersicht (493) Autorinnen und Autoren (503) Quellen (511) Einband ( - ) Farbkeil ( - )

The aim of this article is to provide an input for a discussion about the situation of a Danish (Nordic) model of adult education in the context of European policy as well as globalization. The article will seek to conceptualize the tension between adult education which is founded in and aiming at local participants and contexts and a globalization process which redefines the cultural environment and presents a new and challenging agenda for adult learning. I will apply a rather general framework of historical analysis of adult education which is derived from and related to European modernization (Salling Olesen 2009) on the history of Danish adult education and the possible contemporary impacts of this history (Salling Olesen 1985;1989). It looks at the societal nature of adult learning and hence the societal functions of adult education, and emphasizes the historical dimension in the sense of linking adult education to local socioeconomic, political, and cultural dynamics. Having done that I will return to the question about how we can see adult education in the context of globalization.

Valentin Otamanovsky name has been undeservedly forgotten for many years. He was known in Ukraine above all as a public figure. Foreigner historiographers started to investigate his public activity and scientific heritage early then Soviet scientists.Peter Mirchuk and Roman Mlinovetsky were the first Ukrainian historiographers in the USA who analyzed Otamanovsky's biography, beliefs and aspirations, his scientific papers. Thanks to their research, the name of Valentine Otamanovsky entered the most famous emigrant encyclopaedia.The purpose of this study – a historical overview of P. Mirchuk and R. Mlinovetsky researches, which showed Valentin D. Otamanovsky political activity. We also studied the other Diaspora historians works, which were dialled with Otamanovsky investigation.The historiography of the problem is sparse. Since the time of Ukrainian independence the participants of Otamanovsky in the national liberation movement 1917-1918 has been completely studied. Ukrainian and foreign historians didn't pay attention to him as a scientist. Valentin Otamanovsky was a specialist in the Right Bank Ukrainian cities history during the Middle Ages. Also he was a famous researcher of medicine and pharmacy history and local historian. In addition, Valentin Otamanovsky was highly qualified bibliographer, a talented writer, translator, teacher, educator.Some information about Otamanovsky social life were written in encyclopaedic articles which were published during the years of Ukrainian independence. But the main characteristics of his scientific have remained unstudied.Zoryana Savchuk dedicated the complex investigation of Valentin Otamanovsky activity in her scientific dissertation work. A professor of Kharkiv National Medical University Igor Robak researched the last years of Valentin Otamanovsky's life, which were closely connected with the history medical education in Kharkiv.The foreign historians paid more attention to Valentin Otamanovsky activity as a member of «Brotherhood of the state independence» organization an The Central Rada (The Central Council). The role of Otamanovsky in the process of the Central Rada creation was complexly analyzed. According to Roman Mlinovetsky, Valentin D. Otamanovsky was the founder of the first Ukrainian government in the twentieth century.Petro Mirchuk thought that the main role in the Central Rada foundation was played by Kharkiv well known lawyer and revolutionary figure Mykola Mikhnovsky. But it should be noted that Roman Mlinovetsky allegations were more convincing because he was a contemporary of the events. This author was the first who investigated Valentine Otamanovsky activity as the member of the «Brotherhood of the state independence» organization.Particular attention in this paper was given to Igor Fediv allegations refutations. This author named himself the main author of the famous work «The Son of Ukraine». After the Second World War this book was reprinted in Germany with his corrections. But Igor Fediv composed the text, but he was not a writer. Subsequently the truth was restored when American publication «Ukrainian nationalist» reprinted the text without I. Fedivs remarks. Modern readers received opportunity to read the real book, which was written by Valentin D. Otamanovsky in 1919.Valentin Otamanovsky revolutionary activity is well investigated in foreign historiography. Many interesting and truthful facts of his biography were presented by his best friend and colleague Roman Mlinovetsky. But R. Mlinovetsky couldn't continue his researches when their life ways were parted. Thus, the scientific activity of Valentin Otamanovsky has not received adequate attention by the foreign historians and it needs the further research. ; Рассмотрены исторические работы представителей украинской диаспоры в Канаде и США, а именно, работы Р. Млиновецкого и П. Мирчука. Проанализированы те работы, в которых рассматривается деятельность В. Д. Отамановского – выдающегося участника украинского освободительного движения 1917-1918 гг. Отображены интересные факты деятельности будущего ученого и организатора науки, определена его роль в создании Украинской Центральной Рады. ; Розглянуто історичні розвідки представників української діаспори у Канаді та США, зокрема, праці Р. Млиновецького та П. Мірчука. Проаналізовані ті роботи, які стосуються діяльності В. Д. Отамановського – видатного учасника українських визвольних змагань 1917-1918 рр. Відтворені цікаві факти діяльності майбутнього вченого і організатора науки, зокрема визначена його роль у створенні Української Центральної Ради.