Sex Differences and Psychiatric Disorders
In: The American journal of sociology, Band 81, Heft 6, S. 1447-1454
ISSN: 1537-5390
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In: The American journal of sociology, Band 81, Heft 6, S. 1447-1454
ISSN: 1537-5390
In: The American journal of sociology, Band 82, Heft 4
ISSN: 1537-5390
In: Journal of developmental and physical disabilities, Band 34, Heft 3, S. 505-527
ISSN: 1573-3580
In: Hannema , S E & De Rijke , Y B 2018 , ' Improving Laboratory Assessment in Disorders of Sex Development through a Multidisciplinary Network ' , Sexual development , vol. 12 , no. 1-3 , pp. 135-139 . https://doi.org/10.1159/000486329
The aim of the European Reference Network for Rare Endocrine Disorders (Endo-ERN) is to ensure equal access to high-quality care for all those affected by a rare endocrine condition across Europe, such as a disorder/difference of sex development (DSD), both for children and adults. Although differences in resources, health care systems, and health insurances between the European countries are challenging and require political action, a European laboratory network within Endo-ERN could improve the diagnostic process in individuals with DSD, building on the work done by previous European collaborations such as the COST action DSDnet. In close collaboration, clinicians and laboratory specialists must make every effort to standardize diagnostic protocols, achieve necessary harmonization of various laboratory tests, e.g., the hCG stimulation test, and implement an external quality control system. This should ideally result in comparable quality across the network centers allowing the sharing of reference values. This would not only improve patient care but also greatly facilitate research.
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In: The journal of psychology: interdisciplinary and applied, Band 35, Heft 1, S. 155-160
ISSN: 1940-1019
In: The Journal of sex research, Band 7, Heft 1, S. 1-12
ISSN: 1559-8519
In: Van De Grift , T C & Kreukels , B P C 2019 , ' Breast development and satisfaction in women with disorders/differences of sex development ' , Human Reproduction , vol. 34 , no. 12 , pp. 2410-2417 . https://doi.org/10.1093/humrep/dez230
STUDY QUESTION: What are the levels of breast development and satisfaction in women with a Disorder/Difference of Sex Development (DSD)? SUMMARY ANSWER: Compared with normative data, women with DSD reached lower Tanner stages and reported less breast satisfaction. WHAT IS KNOWN ALREADY: Women with DSD may have chromosomal and hormonal variations that can impact typical breast development. While much emphasis is placed on genital development in this group, little is known about breast development, satisfaction and their association. STUDY DESIGN, SIZE, DURATION: Data collection was part of the cross-sectional European multicenter dsd-LIFE study. Fourteen recruiting sites included 1040 participants between February 2014 and September 2015. PARTICIPANTS/MATERIALS, SETTING, METHODS: A total of 695 female-identifying participants were included (Turner n = 332, 46,XY DSD n = 141 and congenital adrenal hyperplasia n = 222), with a median age of 28 years. Clinical (i.e. history of hormone and surgical treatments, Tanner breast examination) and patient-reported (i.e. breast satisfaction, relationship status, sexual satisfaction and experienced femininity) data was collected by independent trained research staff. The relationship between breast development, satisfaction and femininity was assessed. Control data on breast development and satisfaction in women without DSD was retrieved from the literature. MAIN RESULTS AND THE ROLE OF CHANCE: Of the 695 participants, 61% had received estrogen replacement and 51% puberty induction therapy, whereas 2% had received breast augmentation surgery. Approximately 65% of participants had reached Tanner breast stage 5, which is substantially less than the general population (90%). Breast satisfaction was lower than normative data as well (P < 0.001, Cohen's d = 0.45). Breast size and breast satisfaction were associated with feelings of femininity. LIMITATIONS, REASONS FOR CAUTION: Limitations include the sample representativeness (e.g. regarding the clinical heterogeneity) and the limited in-depth knowledge on (prior) hormonal regimens. Furthermore, no (matched) control data was collected as part of this study. WIDER IMPLICATIONS OF THE FINDINGS: In order to support the psychosexual well-being of women with DSD, enhancing breast development by sufficient hormone replacement and possible augmentation surgery is advocated. The scope of DSD management should be beyond genital development only and consider breasts as well. STUDY FUNDING/COMPETING INTEREST(S): The study was funded by the European Union Seventh Framework Program (FP7/2007-2013) under grant agreement no. 305 373. There are no competing interests. TRIAL REGISTRATION NUMBER: German Clinical Trials Register: Registration identification number: DRKS00006072.
BASE
The aim of the European Reference Network for Rare Endocrine Disorders (Endo-ERN) is to ensure equal access to high-quality care for all those affected by a rare endocrine condition across Europe, such as a disorder/difference of sex development (DSD), both for children and adults. Although differences in resources, health care systems, and health insurances between the European countries are challenging and require political action, a European laboratory network within Endo-ERN could improve the diagnostic process in individuals with DSD, building on the work done by previous European collaborations such as the COST action DSDnet. In close collaboration, clinicians and laboratory specialists must make every effort to standardize diagnostic protocols, achieve necessary harmonization of various laboratory tests, e.g., the hCG stimulation test, and implement an external quality control system. This should ideally result in comparable quality across the network centers allowing the sharing of reference values. This would not only improve patient care but also greatly facilitate research.
BASE
World Affairs Online
In: Reproductive sciences: RS : the official journal of the Society for Reproductive Investigation, Band 18, Heft 8, S. 702-712
ISSN: 1933-7205
In: The American journal of sociology, Band 96, Heft 6, S. 1604-1606
ISSN: 1537-5390
In: The Journal of sex research, Band 3, Heft 1, S. 49-61
ISSN: 1559-8519
In: The Journal of sex research, Band 37, Heft 3, S. 195-204
ISSN: 1559-8519
In: Alcohol and alcoholism: the international journal of the Medical Council on Alcoholism (MCA) and the journal of the European Society for Biomedical Research on Alcoholism (ESBRA), Band 54, Heft 4, S. 339-341
ISSN: 1464-3502