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Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation. Therefore, interfering with Sema3A signaling is proposed as a therapeutic target for achieving functional recovery after CNS injuries. It has been shown that Sema3A adheres to the proteoglycan component of the extracellular matrix (ECM) and selectively binds to heparin and chondroitin sulfate-E (CS-E) glycosaminoglycans (GAGs). We hypothesize that the biologically relevant interaction between Sema3A and GAGs takes place at Sema3A C-terminal polybasic region (SCT). The aims of this study were to characterize the interaction of the whole Sema3A C-terminal polybasic region (Sema3A 725–771) with GAGs and to investigate the disruption of this interaction by small molecules. Recombinant Sema3A basic domain was produced and we used a combination of biophysical techniques (NMR, SPR, and heparin affinity chromatography) to gain insight into the interaction of the Sema3A C-terminal domain with GAGs. The results demonstrate that SCT is an intrinsically disordered region, which confirms that SCT binds to GAGs and helps to identify the specific residues involved in the interaction. NMR studies, supported by molecular dynamics simulations, show that a new peptoid molecule (CSIC02) may disrupt the interaction between SCT and heparin. Our structural study paves the way toward the design of new molecules targeting these protein–GAG interactions with potential therapeutic applications. ; This work was funded by the European Union Seventh Framework Programme (FP7/2007–2013) under Project VISION, grant No. 304884, the Spanish Ministry of Science and Innovation/Spanish Research Agency (MCI/AEI/FEDER, RTI2018–096182-B-I00) and AGAUR (2017 SGR 208). ; Peer reviewed

10 páginas.- 4 figuras.- referencias.-Data Availability Statement: All data underlying this article are available in the main publication and in its Supplementary Materials online. ; Unspecific peroxygenases (UPOs), the extracellular enzymes capable of oxygenating a potpourri of aliphatic and aromatic substrates with a peroxide as co-substrate, come out with a new reaction: carbon-chain shortening during the conversion of fatty acids with the well-known UPOs from Coprinopsis cinerea (rCciUPO) and Cyclocybe (Agrocybe) aegerita (AaeUPO). Although a pathway (Cα-oxidation) for shortening the hydrocarbon chain of saturated fatty acids has already been reported for the UPO from Marasmius rotula (MroUPO), it turned out that rCciUPO and AaeUPO shorten the chain length of both saturated and unsaturated fatty acids in a different way. Thus, the reaction sequence does not necessarily start at the Cα-carbon (adjacent to the carboxyl group), as in the case of MroUPO, but proceeds through the subterminal (ω-1 and ω-2) carbons of the chain via several oxygenations. This new type of shortening leads to the formation of a dicarboxylic fatty acid reduced in size by two carbon atoms in the first step, which can subsequently be further shortened, carbon by carbon, by the UPO Cα-oxidation mechanism. View Full-Text ; This research was funded by BioBased Industries Joint Undertaking under the European Union's Horizon 2020 Research and Innovation Programme, grant number 792063 (SusBind project; https://susbind.eu; to A.G., Á.T.M. and M.H.), the PID2020-118968RB-100 project by the Spanish MCIN/AEI/ 10.13039/501100011033 to A.G., and the CSIC projects PIE-202040E185 (to A.G.) and PIE-202120E019 (to Á.T.M.). ; Peer reviewed

The Confederate Graves Survey Archive of the Texas Division, Sons of Confederate Veterans consists of surveys of cemeteries throughout Texas, and portions of Oklahoma and New Mexico. The surveys document the interment of Confederate States of America military veterans. United States of America (Union) veterans, as well as able-bodied men at the time of the Civil War, are also documented. 13 boxes entitled "Grave Surveys" contain grave surveys listed county-by-county, 3 boxes of "Unit Files" list surveyed individuals by their military unit. Finally, 17 boxes contain "Veteran Files" that document each veteran by name in "last name, first name, middle initial" format. An index that cross-references each of the collection series (Grave Surveys, Unit Files, and Veteran Files) is included, as are institutions to surveyors on how and what to document while conducting surveys. ; Pendleton Cemetery #678, Pendleton, Bell County, Texas | Veterans Interred: Brown, E. A. ; Abilene Cemetery #138, Abilene, Taylor County, Texas | Veterans Interred: Thomas, J. W. ; Abilene Cemetery #138, Abilene, Taylor County, Texas | Veterans Interred: Thomas, J. H. ; Weiland Cemetery #578, Weiland, Hunt County, Texas | Veterans Interred: Phillips, Robt Jackson. ; King Cemetery #685, Coryell County, Texas | Veterans Interred: Moseley, Elisha Alfred. ; Norton Cemetery #915, Runnels County, Texas | Veterans Interred: McDaniel, James M. ; Dickens Cemetery #340, Dickens, Dickens County, Texas | Veterans Interred: Sheilds, Thos. Jefferson. ; Shady Grove Cemetery #634, Wood County, Texas | Veterans Interred: Crone, Franklin M. ; Shady Grove Cemetery #634, Wood County, Texas | Veterans Interred: Jarred, James. ; Shady Grove Cemetery #634, Wood County, Texas | Veterans Interred: Brawning, Thomas. ; Moody Cemetery #28, Moody, McLennon County, Texas | Veterans Interred: Phillips, A. J. ; Weiland Cemetery #578, Weiland, Hunt County, Texas | Veterans Interred: Cummings, Henry. ; Weiland Cemetery #578, Weiland, Hunt County, Texas | Veterans Interred: Elledge, W. W. ; Forrest Park Cemetery #582, Hunt County, Texas | Veterans Interred: McMillan, Lee G. ; Abilene Cemetery #138, Abilene, Taylor County, Texas | Veterans Interred: Thomas, J. W. ; East Mt. Cemetery #572, Hunt County, Texas | Veterans Interred: Fountain E. P.

The Confederate Graves Survey Archive of the Texas Division, Sons of Confederate Veterans consists of surveys of cemeteries throughout Texas, and portions of Oklahoma and New Mexico. The surveys document the interment of Confederate States of America military veterans. United States of America (Union) veterans, as well as able-bodied men at the time of the Civil War, are also documented. 13 boxes entitled "Grave Surveys" contain grave surveys listed county-by-county, 3 boxes of "Unit Files" list surveyed individuals by their military unit. Finally, 17 boxes contain "Veteran Files" that document each veteran by name in "last name, first name, middle initial" format. An index that cross-references each of the collection series (Grave Surveys, Unit Files, and Veteran Files) is included, as are institutions to surveyors on how and what to document while conducting surveys. ; Hogeye Cemetery #759, Hunt County, Texas | Veterans Interred: Tatom, Felix G. ; Wesley Chpl. Cemetery #773, Hunt County, Texas | Veterans Interred: Byars, Daniel W. ; Panhandle Cemetery #193, Panhandle, Carson County, Texas | Veterans Interred: Jameson, Wm. Savage. ; Miami Cemetery #202, Miami, Roberts County, Texas | Veterans Interred: Whatley, John Williams. ; Highland Cemetery #154, Stanford, Haskell County, Texas | Veterans Interred: Self, John M. ; Highland Cemetery #154, Stanford, Haskell County, Texas | Veterans Interred: Buie, Archibald. ; Terrace Cemetery #377, Post, Garza County, Texas | Veterans Interred: Smith, Isaac. ; McWright Cemetery #573, Greenville, Hunt County, Texas | Veterans Interred: VanCleave, George W. ; Forrest Prk Cemetery #582, Hunt County, Texas | Veterans Interred: Ende, Fred Von. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Robey, James Garrison. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Lamar, J. H. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Latimer, Isham Pruitt. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Gee, Robert B. ; Quay Cemetery #722, Quay County, New Mexico. ; Graham Point Cemetery #756, Hunt County, Texas | Veterans Interred: VanCleave, Wm. Grenade. ; Hooker Ridge Cemetery #760, Hunt County, Texas | Veterans Interred: Fortenberry, Oliver A. ; Plainview Cemetery #317, Plainview, Hale County, Texas | Veterans Interred: Howell, Alfred T. ; Kress Cemetery #186, Kress, Swisher County, Texas | Veterans Interred: Askey, James Harrison. ; West Park Cemetery #184, Hereford, Deaf Smith County, Texas | Veterans Interred: Rector, Thos. K. ; Dreamland Cemetery #192, Canyon, Randall County, Texas | Veterans Interred: Slack, Oliver Perry. ; Rosston Cemetery #1048, Rosston, Cooke County, Texas | Veterans Interred: Glover, Isaac. ; East Mount Cemetery #572, Hunt County, Texas | Veterans Interred: Arnold, Marcellus M. ; Kelly Cemetery #763, Hunt County, Texas | Veterans Interred: Walker, Wesley Clark. ; Shiloh Cemetery #591, Campbell, Hunt County, Texas | Veterans Interred: Voyles, Rudolphus. ; Abilene Cemetery #1138, Abilene, Taylor County, Texas | Veterans Interred: Sorelle, Wiley H.

The writings of the Indian Diaspora have received a great deal of attention and critical acclaim throughout the world. Rohinton Mistry is a well renowned author in the contemporary commonwealth literature and occupies a significant place among the writers of Indian Diaspora. Even though he is settled in Canada; it is his upbringing in Mumbai that reflects in all his writings. The distinct Mumbai culture, particularly the Parsee way of life, the people of the city and even the politics of India are major themes in his novels. Rohinton Mistry as a writer of Diaspora has carved a niche for himself. His works such as: "Tales from Firozsha Baag", "Such A Long Journey", "A Fine Balance" and "Family Matters"; mark a new kind of writing, resulting from a fragmented, splintered world. As a Diasporic Parsi writer, very sensitively he has recalled his community's journey through time and history with a sense of loss and nostalgia. His books portray diverse facets of Indian socioeconomic life; as well as Parsi Zoroastrian life, customs, and religion. Many of his writings are markedly "Indo-nostalgic". Rohinton Mistry through his Diasporic discourse has well depicted his ancestral background, his community's engaged situation in a metropolis like Bombay and his deep attachment with and nostalgia for a world gone by. In this paper an attempt has been made to delineate diasporic discourse in the works of Rohinton Mistry. Although he is obsessed with the colonial and postcolonial experiences in India, we can find some traces of Canada in his literature. His characters dream of being integrated into, and accepted by, Canadian society on the one hand and on the other hand, these same characters are torn by an insatiable desire to be true to their native culture; to honor and cherish their own, distinct cultural identity.Keywords: Diaspora, Cultural identity, Contemporary Canadian literature, Parsi.

Cover -- Title Page -- Copyright -- Contents -- America's Unsung Hero -- Growing Up with Inequality -- Hardships as a Young Adult -- Early Political Publishing -- A Fateful Meeting with Benjamin Franklin -- Paine Finds His Voice -- A Call for Independence -- Times That Try Men's Souls -- Serving a New Nation -- Rights of Man -- From French Hero to Enemy -- The Age of Reason -- A Mind for Invention -- Coming Back to America -- Inspiration for Workers and Women -- Paine's Legacy for the Nation -- GLOSSARY -- FOR MORE INFORMATION -- FOR FURTHER READING -- BIBLIOGRAPHY -- INDEX -- Back Cover

The Confederate Graves Survey Archive of the Texas Division, Sons of Confederate Veterans consists of surveys of cemeteries throughout Texas, and portions of Oklahoma and New Mexico. The surveys document the interment of Confederate States of America military veterans. United States of America (Union) veterans, as well as able-bodied men at the time of the Civil War, are also documented. 13 boxes entitled "Grave Surveys" contain grave surveys listed county-by-county, 3 boxes of "Unit Files" list surveyed individuals by their military unit. Finally, 17 boxes contain "Veteran Files" that document each veteran by name in "last name, first name, middle initial" format. An index that cross-references each of the collection series (Grave Surveys, Unit Files, and Veteran Files) is included, as are institutions to surveyors on how and what to document while conducting surveys. ; Nix Cemetery #1013, Lampasas County, Texas | Veterans Interred: Faight, Jesse H. ; Crowell Cemetery #620, Crowell, Foard County, Texas | Veterans Interred: Collins, Dempsey Jones. ; McBee Cemetery #658, Taylor County, Texas | Veterans Interred: Lackey, John. ; North Belton Cemetery #001, Bell County, Texas | Veterans Interred: Taylor, E.O. ; Willow Cemetery #444, Haskell, Haskell County, Texas | Veterans Interred: Lackey, Robert A. ; Killeen Cemetery #024, Killeen, Bell County, Texas | Veterans Interred: McVey, John J. ; Truscott Cemetery #609, Truscott, Knox County, Texas | Veterans Interred: Acker, Dearborn A.

Viroporins are viral proteins with ion channel (IC) activity that play an important role in several processes, including virus replication and pathogenesis. While many coronaviruses (CoVs) encode two viroporins, severe acute respiratory syndrome CoV (SARS-CoV) encodes three: proteins 3a, E, and 8a. Additionally, proteins 3a and E have a PDZ-binding motif (PBM), which can potentially bind over 400 cellular proteins which contain a PDZ domain, making them potentially important for the control of cell function. In the present work, a comparative study of the functional motifs included within the SARS-CoV viroporins was performed, mostly focusing on the roles of the IC and PBM of E and 3a proteins. ; This work was supported by grants from the Government of Spain (BIO2013-42869-R and BIO2016-75549-R AEI/FEDER, UE), the European Zoonotic Anticipation and Preparedness Initiative (ZAPI) (IMI_JU_115760), and the U.S. National Institutes of Health (NIH) (0258-3413/HHSN266200700010C awarded to L.E., 2P01AI060699 awarded to L.E. and S.P., and R01 AI129269 awarded to S.P.). V.M.A. and M.Q.M. are grateful for the support of the Government of Spain (FIS2013-40473-P and FIS2016-75257-P AEI/FEDER, UE) and Universitat Jaume I (P1.1B2015-28). C.C.R. received a contract from Fundación La Caixa.