Suchergebnisse

Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation. Therefore, interfering with Sema3A signaling is proposed as a therapeutic target for achieving functional recovery after CNS injuries. It has been shown that Sema3A adheres to the proteoglycan component of the extracellular matrix (ECM) and selectively binds to heparin and chondroitin sulfate-E (CS-E) glycosaminoglycans (GAGs). We hypothesize that the biologically relevant interaction between Sema3A and GAGs takes place at Sema3A C-terminal polybasic region (SCT). The aims of this study were to characterize the interaction of the whole Sema3A C-terminal polybasic region (Sema3A 725–771) with GAGs and to investigate the disruption of this interaction by small molecules. Recombinant Sema3A basic domain was produced and we used a combination of biophysical techniques (NMR, SPR, and heparin affinity chromatography) to gain insight into the interaction of the Sema3A C-terminal domain with GAGs. The results demonstrate that SCT is an intrinsically disordered region, which confirms that SCT binds to GAGs and helps to identify the specific residues involved in the interaction. NMR studies, supported by molecular dynamics simulations, show that a new peptoid molecule (CSIC02) may disrupt the interaction between SCT and heparin. Our structural study paves the way toward the design of new molecules targeting these protein–GAG interactions with potential therapeutic applications. ; This work was funded by the European Union Seventh Framework Programme (FP7/2007–2013) under Project VISION, grant No. 304884, the Spanish Ministry of Science and Innovation/Spanish Research Agency (MCI/AEI/FEDER, RTI2018–096182-B-I00) and AGAUR (2017 SGR 208). ; Peer reviewed

At the end of the 1870s, the oppressive policies of the Argentine State were intensified towards the indigenous people linked to the Southern Border, visible in the punitive expeditions of 1878-1879. In the case of theranqueles, located in the centralPampa, these actions were part of previous strategies of attrition, carried out by the military commanders ofSan LuisandCórdobathrough the diplomatic channel, softening campaigns and co-optation of contingents who, both forced and voluntarily, migrated to the fortsVilla MercedesandSarmiento. From a line of investigation that seeks to reconstruct the itineraries of theranquelessubmitted in the aforementioned context, the article characterizes the imprisonment of the indigenous people taken by the 3rd Expeditionary Division (April-August 1879) under the leadership of Colonel Eduardo Racedo. Its purpose is to describe their living conditions while they were in thePitral Lauquencamp (nearPoitagué), understanding that it simultaneously acted as a place of concentration and distribution of prisoners. ; Al terminar la década de 1870 se intensificaron las políticas opresivas del Estado argentino para con los indígenas ligados a la Frontera Sur, visibles en las expediciones punitivas de 1878-1879. En el caso de los ranqueles, situados en la pampa central, estas acciones se enmarcan en estrategias previas de desgaste ejecutadas por los mandos militares de San Luis y Córdoba a través de la vía diplomática, las campañas de ablandamiento y cooptación de contingentes que migrabande manera forzaday por presentación a los fuertes Villa Mercedes y Sarmiento. Desde una línea de investigación que busca reconstruir los itinerarios de los ranqueles sometidos en ese contexto, el artículo caracteriza elaprisionamiento de los indígenas tomados por la 3aDivisión Expedicionaria (abril-agosto de 1879) bajo el liderazgo del coronel Eduardo Racedo. Su finalidad es describir sus condiciones de vida mientras estuvieron depositados en el campamento Pitral Lauquen (cercano a Poitagué), lugar de concentración y distribución de prisioneros.

Evald Vasilievich Ilyenkov (1924–1979) takes special place in the Russian philosophy: he largely influenced the character of the movement, which may be regarded as "philosophical Renaissance" of the second half of the 20th century originating in our country. Evald introduced a number of ideas that were ahead of their time and could only be truly appreciated nowadays. In particular, it concerns the understanding of how to ascend from the abstract to the concrete when building a scientific theory. In his understanding of the problem of the ideal, Evald Ilyenkov anticipated the central problem of the modern complex of cognitive sciences: "enactivistic" approach and the idea of "broadened cognition".
The objective of the study was to introduce a number of previously unknown texts of the 60s and the 70s by Evald Ilyenkov into scientific circulation, as well as to provide extensive commentaries thereto, develop references, and describe the social and political context of the philosopher's work. To do so, the author uses materials of personal, public and academic archives. During Evald Ilyenkov's lifetime, his works were severely edited, censored and abridged; the goal of the study was to restore the original version of the works and publish manuscripts that had never been released in the Soviet times. By the end of 2020, four volumes of Evald Ilyenkov's collected works have been published. The publisher brings these works to the new level, setting a high standard of translation and studies of the philosopher's global heritage.

The writings of the Indian Diaspora have received a great deal of attention and critical acclaim throughout the world. Rohinton Mistry is a well renowned author in the contemporary commonwealth literature and occupies a significant place among the writers of Indian Diaspora. Even though he is settled in Canada; it is his upbringing in Mumbai that reflects in all his writings. The distinct Mumbai culture, particularly the Parsee way of life, the people of the city and even the politics of India are major themes in his novels. Rohinton Mistry as a writer of Diaspora has carved a niche for himself. His works such as: "Tales from Firozsha Baag", "Such A Long Journey", "A Fine Balance" and "Family Matters";mark a new kind of writing, resulting from a fragmented, splintered world. As a Diasporic Parsi writer, very sensitively he has recalled his community's journey through time and history with a sense of loss and nostalgia. His books portray diverse facets of Indian socioeconomic life; as well as Parsi Zoroastrian life, customs, and religion. Many of his writings are markedly "Indo-nostalgic". Rohinton Mistry through his Diasporic discourse has well depicted his ancestral background, his community's engaged situation in a metropolis like Bombay and his deep attachment with and nostalgia for a world gone by. In this paper an attempt has been made to delineate diasporic discourse in the works of Rohinton Mistry. Although he is obsessed with the colonial and postcolonial experiences in India, we can find some traces of Canada in his literature. His characters dream of being integrated into, and accepted by, Canadian society on the one hand and on the other hand, these same characters are torn by an insatiable desire to be true to their native culture; to honor and cherish their own, distinct cultural identity.

The writings of the Indian Diaspora have received a great deal of attention and critical acclaim throughout the world. Rohinton Mistry is a well renowned author in the contemporary commonwealth literature and occupies a significant place among the writers of Indian Diaspora. Even though he is settled in Canada; it is his upbringing in Mumbai that reflects in all his writings. The distinct Mumbai culture, particularly the Parsee way of life, the people of the city and even the politics of India are major themes in his novels. Rohinton Mistry as a writer of Diaspora has carved a niche for himself. His works such as: "Tales from Firozsha Baag", "Such A Long Journey", "A Fine Balance" and "Family Matters"; mark a new kind of writing, resulting from a fragmented, splintered world. As a Diasporic Parsi writer, very sensitively he has recalled his community's journey through time and history with a sense of loss and nostalgia. His books portray diverse facets of Indian socioeconomic life; as well as Parsi Zoroastrian life, customs, and religion. Many of his writings are markedly "Indo-nostalgic". Rohinton Mistry through his Diasporic discourse has well depicted his ancestral background, his community's engaged situation in a metropolis like Bombay and his deep attachment with and nostalgia for a world gone by. In this paper an attempt has been made to delineate diasporic discourse in the works of Rohinton Mistry. Although he is obsessed with the colonial and postcolonial experiences in India, we can find some traces of Canada in his literature. His characters dream of being integrated into, and accepted by, Canadian society on the one hand and on the other hand, these same characters are torn by an insatiable desire to be true to their native culture; to honor and cherish their own, distinct cultural identity.Keywords: Diaspora, Cultural identity, Contemporary Canadian literature, Parsi.