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Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation. Therefore, interfering with Sema3A signaling is proposed as a therapeutic target for achieving functional recovery after CNS injuries. It has been shown that Sema3A adheres to the proteoglycan component of the extracellular matrix (ECM) and selectively binds to heparin and chondroitin sulfate-E (CS-E) glycosaminoglycans (GAGs). We hypothesize that the biologically relevant interaction between Sema3A and GAGs takes place at Sema3A C-terminal polybasic region (SCT). The aims of this study were to characterize the interaction of the whole Sema3A C-terminal polybasic region (Sema3A 725–771) with GAGs and to investigate the disruption of this interaction by small molecules. Recombinant Sema3A basic domain was produced and we used a combination of biophysical techniques (NMR, SPR, and heparin affinity chromatography) to gain insight into the interaction of the Sema3A C-terminal domain with GAGs. The results demonstrate that SCT is an intrinsically disordered region, which confirms that SCT binds to GAGs and helps to identify the specific residues involved in the interaction. NMR studies, supported by molecular dynamics simulations, show that a new peptoid molecule (CSIC02) may disrupt the interaction between SCT and heparin. Our structural study paves the way toward the design of new molecules targeting these protein–GAG interactions with potential therapeutic applications. ; This work was funded by the European Union Seventh Framework Programme (FP7/2007–2013) under Project VISION, grant No. 304884, the Spanish Ministry of Science and Innovation/Spanish Research Agency (MCI/AEI/FEDER, RTI2018–096182-B-I00) and AGAUR (2017 SGR 208). ; Peer reviewed

Treballs Finals del Màster d'Advocacia, Facultat de Dret, Universitat de Barcelona, Curs: 2019-2020, Tutor: Dos Santos V. Factor, Javier

Social Media and Online Communities -- HGNN-T5 PEGASUS: A Hybrid Approach for Chinese Long Text Summarization -- Prompt-based and Two-stage Training for Few-shot Text Classification -- A Fine-Grained Image Description Generation Method Based on Joint Objectives -- Analyzing Collective Intelligence through Sentiment Networks in Self-Organized Douban Communities -- Similarity Metrics and Visualization of Scholars Based on Variational Graph Normalized Auto-Encoders -- Scholar Influence Maximization via Opinion Leader and Graph Embedding Regression in Social Networks -- Incremental Inductive Dynamic Network Community Detection -- Er-EIR: A Chinese Question Matching Model based on Word-level and Sentence-level Interaction Features -- MOOC dropout prediction using learning process model and LightGBM algorithm -- Nonnegative Matrix Factorization Based on Topology-And-Attribute-Matching Degree for Community Detection -- Unsupervised Multi-population Evolutionary Algorithm for Community Detection in Attributed Networks -- Parallel High Utility Itemset Mining Algorithm on the Spark -- ABCD-HN: An Artificial Network Benchmark for Community Detection on Heterogeneous Networks -- A Multi-Behavior Recommendation Based on Disentangled Graph Convolutional Networks and Contrastive Learning -- How hypergraph-to-graph conversion affects cooperative working visualization: A Multi-metric evaluation -- Vessel Traffic Flow Prediction and Analysis Based on Ship Big Data -- TGPPN: A Transformer and Graph Neural Network based Point Process Network Model -- Dynamic Network Link Prediction Based on Attention and Time Perception -- User's Emotional Diffusion and Public Opinion Evolution Under Public Health Emergencies -- Mobile Edge Computing Offloading Strategy Based on Deep Reinforcement Learning -- Study of Mental Model in Human-Computer Interaction Based on EEG Signal Data -- Collaborative Mechanisms, Models, Approaches, Algorithms and Systems -- A Scholarly Information Retrieval System Incorporating Recommendation with Semantic Similarity -- DAG-based Task Scheduling Optimization in Heterogeneous Distributed Systems -- A Distributed Cross-layer Protocol for Sleep Scheduling and Data Aggregation in Wireless Sensor Networks -- Time Split Network for Temporal Knowledge Graph Completion -- Deep Q-learning Based Circuit Breaking Method for Micro-services in Cloud Native Systems -- FRS4CPP: A Fair Recommendation Strategy Considering Interests of Users; Providers and Platform -- Accelerating Unsupervised Federated Graph Neural Networks Via Semi-Asynchronous Communication -- Life Cycles and Self-organized Criticality of Vietnam Empires: Based on Sandpile Model -- Multi-source Autoregressive Entity Linking Based on Generative Method -- Improving Voice Style Conversion via Self-Attention VAE with Feature Disentanglement -- Deep Reinforcement Learning for Delay and Energy-aware Task Scheduling in Edge Clouds -- A Comprehensive Review of the Oversmoothing in Graph Neural Networks -- A Foreground Feature Embedding Network for Object Detection in Remote Sensing Images -- Visitors Vis: Interactive Mining of Suspected Medical Insurance Fraud Groups -- CERender: Real-time Cloud Rendering Based on Cloud-Edge Collaboration -- Auxiliary Diagnosis of Pneumonia Based on Convolutional Attention and Parameter Migration -- End-to-end Relation-Enhanced Learnable Graph Self-attention Network for Knowledge Graphs Embedding -- Research on Signal Detection and System Recognition Techniques in Private Internet of Things -- Research on Traffic Flow Prediction and Traffic Light Timing Recommendation Technology Based on Vehicle Data Analysis -- Towards Distributed Graph Representation Learning.

Crowd Intelligence and Crowd Cooperative Computing -- Explicit Coordination Based Multi-Agent Reinforcement Learning for Intelligent Traffic Signal Control -- A Crowdsourcing Task Allocation Mechanism for Hybrid Worker Context Based on Skill Level Updating -- Blockchain-Based Multi-factor K-anonymity Group Location Privacy Protection Scheme -- Context-Aware Automatic Splitting Method for Structured Complex Crowdsourcing Tasks -- A Method for Security Traffic Patrolling Based on Structural Coordinated Proximal Policy Optimization -- Crowdsourced Task Recommendation via Link Prediction -- Research on Multi-UAV Target Allocation Based on Improved Auction Algorithm -- Enhancement of Cat Breeds Classification Model based on Meta Loss Correction -- Multi-UAV Cooperative Reconnaissance Task Allocation Based on IEPPSO Algorithm -- Cooperative Evolutionary Computation and Human-like Intelligent Collaboration -- Group Role Assignment with Trust between Agents -- Memetic Algorithm with Exchange Coding for Intelligent Scheduling Optimization -- A Dimension-Based Elite Learning Particle Swarm Optimizer For Large-Scale Optimization -- Compactness and Separateness Driven Fuzzy Clustering Validity Index Called TLW -- Cross-lingual Speaker Transfer for Cambodian based on Feature Disentangler and Time-Frequency Attention Adaptive Normalization -- Refining Skeleton-based Temporal Action Segmentation with Edge Information -- CoME: Collaborative Model Ensemble for Fast and Accurate Predictions -- Study on the evolution of public opinion on public health events -- Enhance the Transferability From an Overfitting Perspective -- CMGN: Cross-Modal Grounding Network for Temporal Sentence Retrieval in Video -- Fast Community Detection Based on Integration of Non-cooperative and Cooperative Game -- Professional Text Review Under Limited Sampling Constraints -- Latent Diffusion Model-Based T2T-ViT for SAR Ship Classification -- Domain-Specific Collaborative Applications -- An Empirical Study On the Urgent Self-Admitted Technical Debt -- Modular Joint Training for Speech-Driven 3D Facial Animation -- Extracting Structural Knowledge for Professional Text Inference -- Card Mini Program Design and Implementation Based on SCHOLAT Social Network -- A Traffic Flow Prediction based Task Offloading Method in Vehicular Edge Computing -- A Prediction-based Fuzzy Method for Multi-objective Microservice Workflows Scheduling -- Smart Contract Generation Supporting Multi-instance for Inter-Organizational Process Collaboration -- Arterial Traffic Optimization Algorithm Based on Deep Reinforcement Learning and Green Wave Coordination Control in Complex Lane Queuing Conditions -- Multi-robots Formation and Obstacle Avoidance Algorithm based on Leader-follower and Artificial Potential Field Method -- A Multi-stage Network with Self-attention for Tooth Instance Segmention -- Fault Tolerance Aware Virtual Machine Scheduling Algorithm in Cloud Data Center Environment -- Personalized Learning Made Simple: A Deep Knowledge Tracing Model for Individual Cognitive Development -- Vehicle Edge Computing Network Service Migration Strategy Based on Multi-Agent Reinforcement Learning -- A Lightweight Dual Branch Fusion Network for Single Image Deraining -- 3D Object Detection Method Based on LiDAR Point Cloud Data -- Collaborative Computer Vision and Cloud Platform for Gastrointestinal Polyp Detection -- An Intelligent Teaching Evaluation System Integrating Emotional Computing and Cloud Platform -- Deep Learning-Based Fastener Counting and Localization Correction Method -- Design and Simulation of Cooperative Communication Networks for Wireless Sensors in Underwater Environments.

Volume III of National Accounts of OECD Countries comprises Volume IIIa - Financial Accounts - Flows and Volume IIIb - Financial Balance Sheets - Stocks . In both volumes, data, based on the System of National Accounts (SNA 1993), are expressed in national currency (in euros for euro area countries). Volume IIIa covers financial accounts of OECD countries and includes financial transactions (both net acquisition of financial assets and net incurrence of liabilities), by institutional sector (non-financial corporations, financial corporations, general government, households and non-profit insti

"11 December 1978." ; Shipping list no.: 89-483-P. ; "Reprint which includes current pages from changes 1 and 2." ; Cover title. ; Includes bibliographical references. ; Mode of access: Internet. ; 14

Title Page -- Copyright Page -- Table of Contents -- Introduction: New Strategic Realities in a Post-COVID World -- Chapter 1: Workforce Trends -- Chapter 2: Competitive Environment -- Chapter 3: Cybersecurity -- Chapter 4: Consumer Trends -- Chapter 5: Health Equity -- Chapter 6: Artificial Intelligence -- Chapter 7: Capacity Planning -- Chapter 8: Culture of Trust -- About the Contributors -- Back Cover.

Leviticus 18:22 and 20:13 are the only texts in the Old Testament that explicitly condemn homosexual acts. It is of the outmost importance to take the literary context of these texts into consideration. Both prohibitions have family laws as immediate context. Since homosexual acts drastically influence the relations in the larger family, the prohibitions of these acts were associated with the family laws. Leviticus 18 and 20 are closely connected to Leviticus 19, a chapter that emphasises the holiness of the people. The call to holiness in 19:2 concerns all facets of life including sexual relations. The prohibitions against homosexual acts finally belong to the legislation that was given by Yahweh to Moses at Sinai. Therefore Israel had to take them seriously.

"Serial no. 90-35" ; S. 1260, 1752, 1784, 1798, 2047, 2232, 2269; S. J. Res. 75 and 103. ; Mode of access: Internet.

At the end of the 1870s, the oppressive policies of the Argentine State were intensified towards the indigenous people linked to the Southern Border, visible in the punitive expeditions of 1878-1879. In the case of theranqueles, located in the centralPampa, these actions were part of previous strategies of attrition, carried out by the military commanders ofSan LuisandCórdobathrough the diplomatic channel, softening campaigns and co-optation of contingents who, both forced and voluntarily, migrated to the fortsVilla MercedesandSarmiento. From a line of investigation that seeks to reconstruct the itineraries of theranquelessubmitted in the aforementioned context, the article characterizes the imprisonment of the indigenous people taken by the 3rd Expeditionary Division (April-August 1879) under the leadership of Colonel Eduardo Racedo. Its purpose is to describe their living conditions while they were in thePitral Lauquencamp (nearPoitagué), understanding that it simultaneously acted as a place of concentration and distribution of prisoners. ; Al terminar la década de 1870 se intensificaron las políticas opresivas del Estado argentino para con los indígenas ligados a la Frontera Sur, visibles en las expediciones punitivas de 1878-1879. En el caso de los ranqueles, situados en la pampa central, estas acciones se enmarcan en estrategias previas de desgaste ejecutadas por los mandos militares de San Luis y Córdoba a través de la vía diplomática, las campañas de ablandamiento y cooptación de contingentes que migrabande manera forzaday por presentación a los fuertes Villa Mercedes y Sarmiento. Desde una línea de investigación que busca reconstruir los itinerarios de los ranqueles sometidos en ese contexto, el artículo caracteriza elaprisionamiento de los indígenas tomados por la 3aDivisión Expedicionaria (abril-agosto de 1879) bajo el liderazgo del coronel Eduardo Racedo. Su finalidad es describir sus condiciones de vida mientras estuvieron depositados en el campamento Pitral Lauquen (cercano a Poitagué), lugar de concentración y distribución de prisioneros.

The Tweed Family Papers consists primarily of correspondence between Mrs. Richard Tweed and her children, relatives, and friends. Diaries, essays and poetry written by family members, newspaper clippings (photocopies), and financial and legal material are also included, as are a handful of photographs. All related primarily to the life of Mrs. Richard Tweed and her descendants. ; Mrs. Richard Tweed, upon whom the majority of the materials focus, was the sister-in-law of William Marcy ("Boss") Tweed, who controlled the Democratic political machine at New York City's Tammany Hall during the mid-19th century. He and his associates misappropriated public funds on a large scale, leading to his arrest and imprisonment in 1871. ; The Tweed Family Papers are organized by the following categories: Correspondence, Newspapers, Literary Production, Photographs, Financial Material, Printed Material, Scrapbook Material, Legal Material, and Artifacts. ; Tweed Family Papers, 1836-1932 and undated, Southwest Collection/Special Collections Library, Texas Tech University, Lubbock, Texas ; Box 1, File 14