A study of the biological activities of cordyceps militaris and the action mechanisms of the anti-tumor effect of cordycepin
by Lee Kin Ming. ; Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. ; Includes bibliographical references (leaves 214-225). ; Abstracts in English and Chinese. ; ACKNOWLEDGEMENTS --- p.i ; ABBREVIATIONS --- p.ii ; ABSTRACT --- p.vii ; ABSTRACT IN CHINESE --- p.ix ; LIST OF FIGURES --- p.xi ; LIST OF TABLES --- p.xv ; CONTENTS --- p.xvi ; Chapter CHAPTER 1: --- INTRODUCTION --- p.1 ; Chapter 1.1 --- Cordyceps --- p.2 ; Chapter 1.1.1 --- Pharmacological Functions of Cordyceps --- p.5 ; Chapter 1.1.1.1 --- Anti-tumor Activities --- p.5 ; Chapter 1.1.1.2 --- Immunomodulatory Activities --- p.7 ; Chapter 1.1.1.3 --- Hepatic Functions --- p.9 ; Chapter 1.1.1.4 --- Cardiovascular Functions --- p.10 ; Chapter 1.1.1.5 --- Renal Functions --- p.10 ; Chapter 1.2 --- Biological Activities of Cordycepin --- p.12 ; Chapter 1.2.1 --- Inhibition of RNA Synthesis --- p.12 ; Chapter 1.2.2 --- Disruption of Microtubule Network --- p.12 ; Chapter 1.2.3 --- Inhibition of Nucleic Acid Methylation --- p.13 ; Chapter 1.2.4 --- Enhancement of Cell Differentiation --- p.13 ; Chapter 1.2.5 --- Anti-tumor Activity --- p.13 ; Chapter 1.2.6 --- Anti-fungal Activity --- p.14 ; Chapter 1.3 --- Hepatocellular Carcinoma --- p.16 ; Chapter 1.3.1 --- Incidence and Risk Factor of Hepatocellular Carcinoma --- p.16 ; Chapter 1.3.2 --- Treatment of Hepatocellular Carcinoma --- p.16 ; Chapter 1.3.2.1 --- Hepatic Resection --- p.16 ; Chapter 1.3.2.2 --- Liver Transplantation --- p.17 ; Chapter 1.3.2.3 --- Non-surgical Therapeutic Modalities for Hepatocellular Carcinoma --- p.17 ; Chapter 1.3.3 --- Human Hepatocellular Carcinoma Cell Lines --- p.20 ; Chapter 1.3.3.1 --- Human Hepatocellular Carcinoma Cell Line HepG2 --- p.20 ; Chapter 1.3.3.2 --- Multidrug Resistant Human Hepatocellular Carcinoma Cell Line R-HepG2 --- p.20 ; Chapter 1.4 --- Multidrug Resistance of Tumor Cells --- p.22 ; Chapter 1.4.1 --- Multidrug Resistance Mediated by P-Glycoprotein --- p.22 ; Chapter 1.4.1.1 --- Location and Structure of P-Glycoprotein --- p.22 ; Chapter ...