Suchergebnisse

In this study nine coumarin-3-carboxamide derivatives 3a-3i were synthesized with coumarin-3-carboxylic acid chloride and different amines. Two of them, 3c and 3i, are original. The novel substances were purified by column chromatography, and their structures were identified by spectroscopic methods (1H NMR, 13C NMR, IR) and elemental analysis. Coumarin-3-carboxamide derivatives were evaluated antimicrobially against ten different ATTC isolates. The compound 3f was found to be the most effective compound in terms of antibacterial and antifungal activities.

"Objectives: Vaccination is one of the most effective scientific inventions to prevent infectious diseases worldwide. Despite the evidence on the efficacy of vaccinations, vaccine refusal still poses a threat for human health. This study aims, firstly, to detect the underlying reasons of vaccine hesitancy concerning the COVID-19 among medical students and healthcare professionals; and, secondly, to compare the results between the two groups. Methods: This is an online, ongoing cross-sectional quantitative study based on a scale validated in the socio-cultural context in Turkey. The sample consists of students of medicine at six years of education including preparatory class at a foundation university in Istanbul, as well as the healthcare professionals at the affiliated hospitals of the same university. Data will mainly be collected through the Scale of Vaccine Hesitancy (1) annexed with demographic and open-ended questions detecting opinions about vaccination. T-test and chi-square tests will be used for the analysis of scale scores and demographic questions respectively. The open-ended questions will provide deeper findings on the issue. Discussion and Conclusion: While COVID-19 pandemic remains a global challenge, vaccine roll-out seems to be the best response to combat the disease. However, reluctance in acceptance of vaccines among diverse populations creates a risk for herd immunity. Comparatively investigating the motives of vaccine hesitancy among health-related populations may help proposing social, ethical guidance for medical education and health policies. Source: Kilincarslan, M. et al (2020). Development of Valid and Reliable Scale of Vaccine Hesitancy in Turkish Language. Konuralp Tıp Dergisi, 12(3), 420-429 . "

The prime aims of the present work at formulating and preparing matrix tablets using Carbopol 974P to sustain the release of donepezil HCl. Tablets were prepared by direct compression method and evaluated for the effects of ingredients on the in-vitro release behavior. Gelatin, α-cellulose, sodium alginate, hydroxyapatite, and natural zeolite (clinoptilolite) were used as co-excipients to modulate the formulations. The prepared tablets of the 10 formulations were characterized by using Fourier transform infrared spectroscopy (FT-IR), digital microscope and scanning electron microscopy (SEM) techniques. The drug release kinetics was analyzed using Zero-order, First-order, Hixson-Crowell and Peppas models. The result indicated that the drug release rates highly depended on the polymers and pH medium. In addition, it was obtained that the combination of Carbopol 974P and gelatin retarded the drug release. So, these matrix tablets can reduce the dose intake. Thus, these matrix tablets are a promising release of donepezil HCl.

The diffusion of building information modelling (BIM) has remained slow and the search for a solution to the problems that prevent technology acceleration continues. Although, there is strong evidence that user resistance is a major factor in delaying the adoption of new technologies, little attention has been paid to the drivers of BIM use in literature. Besides, majority of the studies on organisational barriers focus on large firms, despite strong emphasis laid on increased collaboration in the BIM. In the current study, the drivers of and barriers to BIM adoption and implementation are explored at both individual and organisational levels through a survey conducted on 905 industry professionals from the Turkish construction industry. This study further explores differences between groups of firm size in embracing BIM technologies to assess the extent and presence of digital divide. Results reveal that professionals place more value on performance enhancing factors rather than social influence for the adoption of BIM, indicating the role of improved performance as a driver for BIM. The most prominent barriers, on the other hand, appear to be related to the availability of expertise and skills, a problem that seems to exist not solely within companies but also further down the supply chain. Policymakers seeking to disseminate BIM use may address these concerns and consider these insights to revise policies and incentives.

"There are conflicting data on the effects of magnesium on hypertension in the literature. Therefore we aim this study to investigate whether there is a relationship between serum magnesium levels and hypertension in newly diagnosed. This is a case-control study. The patients were selected from the records of patients who applied to the family medicine outpatient clinic between June 2016 and May 2017. A total of 276 patients, 68 patients with newly diagnosed hypertension in the case group and 208 patients without any disease in the control group were included in the study. Binary logistic regression analysis was performed between the case and control groups. The odds ratio for magnesium was 0.1 (0.012-0.810). When the value of the magnesium variable increases by 1mg/dl, the risk of hypertension decreases by 90%. However, in the presence of magnesium as an independent variable, the predictability rate of our model was expected to increase but decreased. The odds ratio for age was 1.14 (1.092-1.186). The odds ratio for exercise was 0.18 (0.03-0.99). The odds ratio for glucose was 1.03 (1.001-1.065). In our study that magnesium deficiency causes an increased risk of hypertension, the predictability rate of our model was expected to increase instead of decrease. These findings show that a cause-effect approach or incidental association cannot explain the relationship between magnesium and hypertension."

An ultra fast liquid chromatographic (UFLC) method using fluorimetric detection for the quantitation of Febuxostat (FEB) in human serum was developed by precolumn derivatization with 4-bromomethyl-7-methoxy coumarin (BrMmC). The derivatization was catalyzed with dibenzo-18-crown-6-ether to produce a fluorescent derivative which was determined through fluorescence measurement with excitation at 320 nm and emission at 395 nm wavelengths. A C18 column with 100 cm x 4.6 mm, 3 µm particule size was used for the UFLC separation procedure. A mixture of acetonitrile: methanol: 0.05 M aqueous ammonium acetate (pH 5.0) (40:40:20, v/v/v) was used as mobile phase. During the procedure, the flow rate was maintained at 0.5 mL/min. A calibration curve was then plotted as 0.005–3.0 µg/mL with a detection limit of 0.0022 µg/mL and quantification limit of 0.0073 µg/mL. The mean recovery to reveal the accuracy and relative standard deviation (RSD) that indicates the precision of the method were found out to be 85.20 % and less than 3.52 %, respectively. The utility of the new method has been demonstrated by measuring the pharmacokinetics of FEB by administration of 80 mg tablets to a healthy female volunteer, aged 42.