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Among the variety of modern nanomaterials a special class – nanoflowers can be distinguished. These new nanostructures have induced the interest of scientists due to the topographic features of nanolayers, the special location of which allows a higher surface-to-volume ratio compared to classical spherical nanoparticles. Such topographic structure significantly increases the efficiency of surface reactions for nanoflowers. The main purpose of this type of nanomaterials is their use as enzyme stabilizers. Enzymes are biosystems with high activity and substrate specificity, but their use is limited by certain disadvantages, such as high sensitivity to the environment, low reproducibility of experimental results and requirements for complex purification of the components. To facilitate the functioning of enzymes in various conditions, organicinorganic hybrid nanomaterials have been developed, the name of which indicates that all components of inorganic nanoparticles are associated with organic materials. These nanoparticles have numerous promising applications in catalysis, as biosensors, and for drug delivery. Organic-inorganic hybrid nanoflowers have led to the development of a new branch of chemistry – the chemistry of hybrid nanomaterials, whose research is currently undergoing rapid development. Thus, the study of organic-inorganic hybrid nanocrystals can lead to new creative solutions in the field of chemistry of enzyme systems and the rapid development of bionanomaterials and new branches of biotechnology.