Introduction to the Risk Assessment Workshop on Indoor Air Quality1
In: Risk analysis: an international journal, Band 10, Heft 1, S. 15-17
ISSN: 1539-6924
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In: Risk analysis: an international journal, Band 10, Heft 1, S. 15-17
ISSN: 1539-6924
In: Risk analysis: an international journal, Band 7, Heft 4, S. 449-461
ISSN: 1539-6924
We analyzed the 1980 U.S. vital statistics and available ambient air pollution data bases for sulfates and fine, inhalable, and total suspended particles. Using multiple regression analyses, we conducted a cross‐sectional analysis of the association between various particle measures and total mortality. Results from the various analyses indicated the importance of considering particle size, composition, and source information in modeling of particle pollution health effects. Of the independent mortality predictors considered, particle exposure measures related to the respirable and/or toxic fraction of the aerosols, such as fine particles and sulfates, were most consistently and significantly associated with the reported SMSA‐specific total annual mortality rates. On the other hand, particle mass measures that included coarse particles (e.g., total suspended particles and inhalable particles) were often found to be nonsignificant predictors of total mortality. Furthermore, based on the application of fine particle source apportionment, particles from industrial sources (e.g., from iron/steel emissions) and from coal combustion were suggested to be more significant contributors to human mortality than soil‐derived particles.
In: Risk analysis: an international journal, Band 27, Heft 1, S. 5-6
ISSN: 1539-6924
In: Air quality, atmosphere and health: an international journal, Band 9, Heft 5, S. 495-502
ISSN: 1873-9326
In: Risk analysis: an international journal, Band 31, Heft 4, S. 592-608
ISSN: 1539-6924
Daily soil/dust ingestion rates typically used in exposure and risk assessments are based on tracer element studies, which have a number of limitations and do not separate contributions from soil and dust. This article presents an alternate approach of modeling soil and dust ingestion via hand and object mouthing of children, using EPA's SHEDS model. Results for children 3 to <6 years old show that mean and 95th percentile total ingestion of soil and dust values are 68 and 224 mg/day, respectively; mean from soil ingestion, hand‐to‐mouth dust ingestion, and object‐to‐mouth dust ingestion are 41 mg/day, 20 mg/day, and 7 mg/day, respectively. In general, hand‐to‐mouth soil ingestion was the most important pathway, followed by hand‐to‐mouth dust ingestion, then object‐to‐mouth dust ingestion. The variability results are most sensitive to inputs on surface loadings, soil‐skin adherence, hand mouthing frequency, and hand washing frequency. The predicted total soil and dust ingestion fits a lognormal distribution with geometric mean = 35.7 and geometric standard deviation = 3.3. There are two uncertainty distributions, one below the 20th percentile and the other above. Modeled uncertainties ranged within a factor of 3–30. Mean modeled estimates for soil and dust ingestion are consistent with past information but lower than the central values recommended in the 2008 EPA Child‐Specific Exposure Factors Handbook. This new modeling approach, which predicts soil and dust ingestion by pathway, source type, population group, geographic location, and other factors, offers a better characterization of exposures relevant to health risk assessments as compared to using a single value.
In: Air quality, atmosphere and health: an international journal, Band 6, Heft 1, S. 195-204
ISSN: 1873-9326
In: Risk analysis: an international journal, Band 26, Heft 2, S. 533-541
ISSN: 1539-6924
A probabilistic model (SHEDS‐Wood) was developed to examine children's exposure and dose to chromated copper arsenate (CCA)‐treated wood, as described in Part 1 of this two‐part article. This Part 2 article discusses sensitivity and uncertainty analyses conducted to assess the key model inputs and areas of needed research for children's exposure to CCA‐treated playsets and decks. The following types of analyses were conducted: (1) sensitivity analyses using a percentile scaling approach and multiple stepwise regression; and (2) uncertainty analyses using the bootstrap and two‐stage Monte Carlo techniques. The five most important variables, based on both sensitivity and uncertainty analyses, were: wood surface residue‐to‐skin transfer efficiency; wood surface residue levels; fraction of hand surface area mouthed per mouthing event; average fraction of nonresidential outdoor time a child plays on/around CCA‐treated public playsets; and frequency of hand washing. In general, there was a factor of 8 for the 5th and 95th percentiles and a factor of 4 for the 50th percentile in the uncertainty of predicted population dose estimates due to parameter uncertainty. Data were available for most of the key model inputs identified with sensitivity and uncertainty analyses; however, there were few or no data for some key inputs. To evaluate and improve the accuracy of model results, future measurement studies should obtain longitudinal time‐activity diary information on children, spatial and temporal measurements of residue and soil concentrations on or near CCA‐treated playsets and decks, and key exposure factors. Future studies should also address other sources of uncertainty in addition to parameter uncertainty, such as scenario and model uncertainty.
In: Risk analysis: an international journal, Band 26, Heft 2, S. 515-531
ISSN: 1539-6924
Concerns have been raised regarding the safety of young children who may contact arsenic residues while playing on and around chromated copper arsenate (CCA)‐treated wood playsets and decks. Although CCA registrants voluntarily canceled the production of treated wood for residential use in 2003, the potential for exposure from existing structures and surrounding soil still poses concerns. The EPA's Office of Research and Development developed and applied the probabilistic Stochastic Human Exposure and Dose Simulation model for wood preservatives (SHEDS‐Wood) to estimate children's absorbed dose of arsenic from CCA. Skin contact with, and nondietary ingestion of, arsenic in soil and wood residues were considered for the population of children in the United States who frequently contact CCA‐treated wood playsets and decks. Model analyses were conducted to assess the range in population estimates and the impact of potential mitigation strategies such as the use of sealants and hand washing after play events. The results show predicted central values for lifetime annual average daily dose values for arsenic ranging from 10−6 to 10−5 mg/kg/day, with predicted 95th percentiles on the order of 10−5 mg/kg/day. There were several orders of magnitude between lower and upper percentiles. Residue ingestion via hand‐to‐mouth contact was determined to be the most significant exposure route for most scenarios. Results of several alternative scenarios were similar to baseline results, except for the scenario with greatly reduced residue concentrations through hypothetical wood sealant applications; in this scenario, exposures were lower, and the soil ingestion route dominated. SHEDS‐Wood estimates are typically consistent with, or within the range of, other CCA exposure models.
In: Air quality, atmosphere and health: an international journal, Band 5, Heft 1, S. 9-62
ISSN: 1873-9326