Suchergebnisse

AbstractAimThere is a deficiency in the data concerning the clinical forms of methotrexate‐induced oral ulcers. This study was conducted to stratify clinical forms of methotrexate‐induced oral ulcers in rheumatoid arthritis patients.MethodsThis study included rheumatoid arthritis patients receiving methotrexate as monotherapy. All eligible patients were subjected to thorough clinical examination and full history to identify oral events. Drug history, dose, and duration of MTX were recorded.ResultsAmong 794 rheumatoid arthritis patients, mean methotrexate dose and duration were 14.3 mg/week and 5.2 years, respectively. Oral ulcers were detected in 6.2% of the patients and 30% of the patients reported previous oral ulcers. Among the detected oral ulcers, 44.9% manifested as deep irregular ulcers, 30.6% presented as aphthous‐like ulcers, 14.3% were diffuse mucositis, and 10.2% appeared as lichenoid reaction.ConclusionMethotrexate‐induced oral ulceration could be localized or generalized. Localized forms were more noticed than generalized forms. Higher doses and longer durations of methotrexate were detected among patients with generalized oral ulcers.

AbstractAimThe current study assessed the clinical characteristics of patients suffering from Behcet's disease (BD)‐associated oral ulcers and investigated the effect of these oral ulcers on the oral health‐related quality of life (OHRQoL).MethodsThis study included BD patients suffering from active oral ulcers, defined by the revised International Criteria for BD (ICBD) criteria. We collected BD and oral ulcers characteristics. The oral ulcer activity index and OHRQoL were measured by composite index (CI) and Oral Health Impact Profile‐14 (OHIP‐14), respectively.ResultsGenital and ocular manifestations were the most frequent. Ocular manifestations were the main diagnostic manifestation. The mean age of BD diagnosis and first oral ulcer appearance were 32.15 ± 8.96 and 29.62 ± 9.04, respectively. Minor oral ulcers were more frequent; solitary or multiple. CI revealed that pain was more severe than functional disability. OHIP‐14 showed that patients suffered more often from pain and difficulties in eating. Patients reported feeling tense, being irritable, doing usual job with difficulty, and having less satisfying life.ConclusionBD‐associated oral ulcers lead to poor quality of life. Female gender, multiple ulcers, and buccal mucosa were associated with more severe pain and functional disability as well as poorer quality of life.