Suchergebnisse

Las pruebas de ciudadanía y naturalización existen desde hace más de un siglo. Conocer su justificación y su importancia internacional implica su propia revisión. Este artículo comienza por definir sus principales características, centrándose en sus dos componentes principales: lengua y cultura. La diferencia en los niveles de competencia en el Marco de Referencia Común Europeo es especialmente relevante. Inmediatamente después, miramos los diferentes exámenes en diferentes países. Una parte importante del trabajo está dirigida al uso de la tecnología en la evaluación y preparación de exámenes enfatizando sus beneficios y dificultades. Adicionalmente, el trabajo también destaca la oportunidad en este momento para su implementación en la red a pesar de los problemas académicos y sociales actuales.

ECM composition and architecture are tightly regulated for tissue homeostasis. Different disorders have been associated to alterations in the levels of proteins such as collagens, fibronectin (FN) or tenascin-C (TnC). TnC emerges as a key regulator of multiple inflammatory processes, both during physiological tissue repair as well as pathological conditions ranging from tumor progression to cardiovascular disease. Importantly, our current understanding as to how TnC and other non-collagen ECM components are secreted has remained elusive. Extracellular vesicles (EVs) are small membrane-bound particles released to the extracellular space by most cell types, playing a key role in cell-cell communication. A broad range of cellular components can be transported by EVs (e.g. nucleic acids, lipids, signalling molecules and proteins). These cargoes can be transferred to target cells, potentially modulating their function. Recently, several extracellular matrix (ECM) proteins have been characterized as bona fide EV cargoes, exosomal secretion being particularly critical for TnC. EV-dependent ECM secretion might underpin diseases where ECM integrity is altered, establishing novel concepts in the field such as ECM nucleation over long distances, and highlighting novel opportunities for diagnostics and therapeutic intervention. Here, we review recent findings and standing questions on the molecular mechanisms governing EV-dependent ECM secretion and its potential relevance for disease, with a focus on TnC. ; The authors acknowledge the grant support to MP from the Spanish Ministerio de Ciencia e Innovación (CSD2009-0016, SAF2014-51876-R, SAF2017-83130-R, BFU2016-81912-REDC, and IGP-SO-MINSEV1512-07-2016), Fundació La Marató de TV3 (674/C/2013 and 201936-30-31), Worldwide Cancer Research Foundation (# 15-0404), Asociación Española Contra el Cáncer (PROYE20089DELP), and Fondo Europeo de Desarrollo Regional "Una manera de hacer Europa". MP received funding from the European Union Horizon 2020 research and innovation program under Marie Sklodowska-Curie grant agreement no. 641639, and is member of the Tec4Bio consortium (ref. S2018/NMT4443; Actividades de I+D entre Grupos de Investigación en Tecnologías, Comunidad Autónoma de Madrid/FEDER, Spain). LA-A was supported by a Ministerio de Ciencia, Innovación y Universidades predoctoral fellowship associated with the Severo Ochoa Excellence program (ref. SVP-2013-06789). The Centro Nacional de Investigaciones Cardiovasculares Carlos III is supported by the Ministerio de Ciencia e Innovación and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). ; Sí

AbstractParthenium hysterophorus L. (Asteraceae) is an invasive alien weed with detrimental effects on agricultural production, biodiversity, human and animal health, threating rural livelihoods in Asia and Africa. The problem emerged recently in the Kenyan Rift Valley, where it began to affect the landholdings of both agro-pastoralists and crop farmers. These vulnerable smallholders depend heavily on natural resources for their livelihoods. In this study, we assessed the severity of parthenium invasion and farmers' management responses using a sample of 530 agro-pastoralists in Baringo County, Kenya, in 2019. We hypothesise that the implementation of existing management strategies depends on the state of parthenium invasion and household socio-economic characteristics. The prevalence and severity of parthenium invasion differed greatly among field plots. To control weeds, farmers resort to either hand weeding, the use of synthetic herbicides, or intensive tillage, sometimes in combination with mulching. A multivariate probit regression model shows that households' characteristics determine the type of control strategies used as well as their complementarity and substitutability. Hand weeding is the most common option, adopted by almost 40% of farmers. The use of agrochemicals or soil-based control strategies appears to be related to knowledge and information characteristics such as access to extension services, membership in organisations and the educational level of household heads. While hand weeding and the use of synthetic herbicides depict significant substitutability, the latter strategy is limited to a few larger farms with market-oriented production. As parthenium invasion continues, policies need to improve farmer awareness and access to knowledge to enable pro-poor and environmentally sustainable control of parthenium on smallholder farms.

This is a short monograph that summarizes a series of meetings of the Mediation Support Network (MSN), a network of primarily non-governmental organizations (NGOs) that support mediation in peace negotiations. Specifically, MSN members discussed and reflected on the "UN Guidance for Effective Mediation" and specifically focused on how to translate the UN Guidance into practice. Rather than being a comprehensive commentary, this document therefore focuses on certain issues and cases that seem pertinent from the MSN perspective. The discussions focused on numerous case studies that illustrate the challenges of mediation, and how they were dealt with. The aim of these case studies – some of them specifically focusing on the NGO role in mediation – is to help translate the UN Guidance into effective practice. A few key themes about mediation were featured: preparedness; consent; impartiality; inclusivity; national ownership; international law and a normative framework; coherence, coordination, and complementarity; and quality peace agreements. Conclusions included the need for mediation to be professionalized and that careful analysis is needed before any mediation action. Such analysis and strategizing requires the long-term development of institutional and human capacity. There is a strong and legitimate call for making mediation processes more inclusive, with regard to the inclusion of a range of actors (e.g., marginalized groups, women, religious actors, etc.) and with regard to the content of a peace agreement. However, mediators often face pressure to reach a minimum agreement quickly, especially when hostilities are ongoing. This can make it particularly difficult to reach more inclusive, and thus more complex, agreements. Inclusivity also entails efforts, outside the formal mediation process, to support dialogue between actors, so that they can better influence formal processes and sustain peace agreements once they are signed. Coordination of mediators benefits from the inclusion of civil society: Local ...