Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- Application of genomics to screening / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Application of genomics to assessment of the ecological risk of complex mixtures / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].
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Die folgenden Links führen aus den jeweiligen lokalen Bibliotheken zum Volltext:
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 64, Heft 2, S. 101-105
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 63, Heft 3, S. 337-342
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 59, Heft 1, S. 1-9
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 58, Heft 1, S. 7-16
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 38, Heft 2, S. 155-160
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 21, Heft 3, S. 266-274
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 74, Heft 6, S. 1461-1470
In: Ankley , G T , Coady , K K , Gross , M , Holbech , H , Levine , S L , Maack , G & Williams , M 2018 , ' A critical review of the environmental occurrence and potential effects in aquatic vertebrates of the potent androgen receptor agonist 17β-trenbolone ' , Environmental Toxicology and Chemistry , vol. 37 , no. 8 , pp. 2064-2078 . https://doi.org/10.1002/etc.4163
Trenbolone acetate is widely used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17β-trenbolone, have been detected at low nanograms per liter concentrations in surface waters associated with animal feedlots. The 17β-trenbolone isomer can affect androgen receptor signaling pathways in various vertebrate species at comparatively low concentrations/doses. The present article provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of 17β-trenbolone, with an emphasis on potential risks to aquatic animals. In vitro studies indicate that, although 17β-trenbolone can activate several nuclear hormone receptors, its highest affinity is for the androgen receptor in all vertebrate taxa examined, including fish. Exposure of fish to nanograms per liter water concentrations of 17β-trenbolone can cause changes in endocrine function in the short term, and adverse apical effects in longer exposures during development and reproduction. Impacts on endocrine function typically are indicative of inappropriate androgen receptor signaling, such as changes in sex steroid metabolism, impacts on gonadal stage, and masculinization of females. Exposure of fish to 17β-trenbolone during sexual differentiation in early development can greatly skew sex ratios, whereas adult exposures can adversely impact fertility and fecundity. To fully assess ecosystem-level risks, additional research is warranted to address uncertainties as to the degree/breadth of environmental exposures and potential population-level effects of 17β-trenbolone in sensitive species. Environ Toxicol Chem 2018;37:2064-2078. Published 2018 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.
In: Aggelen , G V , Ankley , G T , Baldwin , W S , Bearden , D W , Benson , W H , Chipman , K , Collette , T W & Craft , J A 2010 , ' Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook ' , Environmental Health Perspectives , vol. 118 , no. 1 , pp. 1-5 .
In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics—Moving into Regulation and Monitoring, held 21–23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada). The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets.
The fish early life-stage (FELS) test (OECD Test Guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs. As part of an on-going effort to develop efficient and cost-effective alternatives to the FELS test, there is a need to identify and describe potential adverse outcome pathways (AOPs) relevant to FELS toxicity. To support this endeavor, we outline and illustrate an overall strategy for discovery and annotation of FELS AOPs. Key events represented by major developmental landmarks were organized into a preliminary conceptual model of fish development. Using swimbladder inflation as an example, a weight-of-evidence-based approach was used to support linkage of key molecular initiating events to adverse phenotypic outcomes and reduced young-of-year survival. Based on an iterative approach, we explored the feasibility of using key events as the foundation for expanding a network of plausible linkages and AOP knowledge and, in the process, identify important knowledge gaps. Given the scope and scale of the task, prioritization of AOP development was recommended and key research objectives were defined relative to factors such as current animal use restrictions in the European Union and increased demands for fish toxicity data in chemical management programs globally. The example and strategy described are intended to guide collective efforts to define FELS-related AOPs and develop resource-efficient predictive assays that address the toxicological domain of the OECD 210 test.
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 68, Heft 1, S. 20-32