Suchergebnisse

Candida auris is a pathogenic fungus that causes infections in people with weakened immune
systems. It is resistant to antimicrobial drugs, which complicates treatment. C. auris poses a
serious threat to public health, as it has a high resistance and contagiousness. The ribosome plays
an important role in the survival and development of this infection, and the search for inhibitors of the C. auris ribosome is of great importance. We used cryoelectron microscopy and single
particle analysis to obtain the three-dimensional structure of the C. auris ribosome. We describe
the architecture of the ribosome subunits and their interactions, providing valuable information
for the development of novel anti-fungals against C. auris.