Paradigms and Public Policies on Drought in Northeast Brazil: A Historical Perspective
In: Environmental management: an international journal for decision makers, scientists, and environmental auditors, Band 55, Heft 5, S. 1052-1063
ISSN: 1432-1009
9 Ergebnisse
Sortierung:
In: Environmental management: an international journal for decision makers, scientists, and environmental auditors, Band 55, Heft 5, S. 1052-1063
ISSN: 1432-1009
This paper describes the evolution of drought-related public policies in Northeast Brazil (NEB). Using a historical approach, we show that the evolution of public policy has not been characterized by abrupt shifts, but has instead been shaped through debates between renowned intellectuals. The resulting public policies formed a hydrological infrastructure that delivers clean water needed for robust economic activity. However, outcomes of the 2012–2013 drought show that populations that depend on rain fed agriculture are as vulnerable to drought as they were at the start of the 20th century. Although government, social, and emergency programs have aided drought victims, drought analysts agree that rain fed agriculture has remained vulnerable since drought policies were first formulated. Drought policies formulate integrated water resources management (IWRM) strategies that are geared toward supplying safe drinking water, and debates surrounding the IWRM paradigm have been affected by outcomes of major international events such as the World Water Forum.
BASE
In: Journal of urban and environmental engineering: JUEE, S. 167-174
ISSN: 1982-3932
The paper presents a case study integrating hydrologic models, hydraulic models and a geographic information system (GIS) to delineate flooded areas in the medium-sized Acaraú River Basin in Ceará State, Brazil. The computational tools used were HEC-HMS for hydrologic modelling, HEC-RAS for hydraulic modelling and HEC-GeoRAS for the GIS. The results showed that a substantial portion of the riverine populations of the cities of Sobral, Santana do Acaraú and Groairas were affected by floods. Overall, the flood model satisfactorily represents the affected areas and shows the locations with the greatest flooding.
In: Emerging adulthood, Band 11, Heft 1, S. 110-120
ISSN: 2167-6984
Hooking up may be one pathway for sexual and gender minority (SGM) emerging adults to explore their sexual identity development while they navigate heteronormative milestones. Framed by Dillon et al.'s (2011) model of universal sexual identity development, we examined 24 interviews with SGM emerging adults to understand whether and how hooking up aided in the development of their sexual identities beyond their sexual orientation. Although some participants already reported stable sexual identities prior to hooking up, we identified that hooking up did lead others to develop their sexual preferences more fully, better understand their sexual identity, and strengthen their connections to the SGM community. These findings suggest that hooking up can facilitate positive sexual development among sexual and gender minority emerging adults.
The performances of gas chromatography with mass spectrometry and of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry are examined through the comparison of Daphnia magna metabolic profiles. Gas chromatography with mass spectrometry and comprehensive two-dimensional gas chromatography with mass spectrometry were used to compare the concentration changes of metabolites under saline conditions. In this regard, a chemometric strategy based on wavelet compression and multivariate curve resolution–alternating least squares is used to compare the performances of gas chromatography with mass spectrometry and comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry for the untargeted metabolic profiling of Daphnia magna in control and salinity-exposed samples. Examination of the results confirmed the outperformance of comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry over gas chromatography with mass spectrometry for the detection of metabolites in D. magna samples. The peak areas of multivariate curve resolution–alternating least squares resolved elution profiles in every sample analyzed by comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry were arranged in a new data matrix that was then modeled by partial least squares discriminant analysis. The control and salt-exposed daphnids samples were discriminated and the most relevant metabolites were estimated using variable importance in projection and selectivity ratio values. Salinity de-regulated 18 metabolites from metabolic pathways involved in protein translation, transmembrane cell transport, carbon metabolism, secondary metabolism, glycolysis, and osmoregulation. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ; Hadi Parastar would like to thank Sharif University of Technology (SUT) of Iran for financial support for a short sabbatical leave at IDAEA-CSIC. The research leading to these results received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement no. 320737 ; Peer reviewed
BASE
Tryptophan hydroxylase (TRH) is the rate limiting enzyme in the serotonin synthesis. CRISPR-Cas9 technology was used to generate seven indel TRH mutants in Daphnia magna. Mono-allelic indel TRH-/+ clones showed normal levels of serotonin, measured by both immunohistochemistry and mass spectrometry (LC-MS/MS), whereas bi-allelic indel TRH-/- clones showed no detectable levels of serotonin. Life history and behavioral responses of TRH-/- clones showed the anti-phenotype of those exposed to selective serotonin reuptake inhibitors (SSRI). Mutants lacking serotonin grew less and hence reproduced latter, produced smaller clutches of smaller offspring and responded to a greater extent to light than wild type individuals. Mono-allelic indel TRH-/+ individuals showed the intermediate phenotype. The SSRI fluoxetine enhanced offspring production in all clones and decreased the response to light only in those clones having serotonin, thus indication that behavioral effects of this drug in D. magna are associated to serotonin. Results obtained with the TRH mutants are in line with reported ones in TRH knockouts of Caenorhabditis elegans, Drosophila and mice, indicating that there is one gene encoding TRH, which is the serotonin limiting enzyme in both the central and the periphery nervous system in Daphnia and that deprivation of serotonin increases anxiety-like behavior. © 2018 The Author(s). ; C.R. was supported by the Spanish PhD fellow BES-2012-053631. This work was supported by the Spanish Government: projects CTM2014-51985-R and CTM2017-83242-R ; Peer reviewed
BASE
In: Ecotoxicology and environmental safety: EES ; official journal of the International Society of Ecotoxicology and Environmental safety, Band 208, S. 111639
ISSN: 1090-2414
In: Environmental science & policy, Band 126, S. 99-110
ISSN: 1462-9011
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types.
BASE