Bile Acid Glucuronides, II. Isolation and Identification of a Chenodeoxycholic Acid Glucuronide from Human Plasma in Intrahepatic Cholestasis
In: Hoppe-Seyler´s Zeitschrift für physiologische Chemie, Band 357, Heft 1, S. 213-218
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In: Hoppe-Seyler´s Zeitschrift für physiologische Chemie, Band 357, Heft 1, S. 213-218
In: Hoppe-Seyler´s Zeitschrift für physiologische Chemie, Band 354, Heft 1, S. 83-89
In: Hoppe-Seyler´s Zeitschrift für physiologische Chemie, Band 357, Heft 1, S. 219-224
In: Hoppe-Seyler´s Zeitschrift für physiologische Chemie, Band 365, Heft 1, S. 479-484
In: Azzopardi-Muscat , N , Schroder-Back , P & Brand , H 2017 , ' The European Union Joint Procurement Agreement for cross-border health threats : what is the potential for this new mechanism of health system collaboration? ' , Health Economics, Policy and Law , vol. 12 , no. 1 , pp. 43-59 . https://doi.org/10.1017/S1744133116000219
The Joint Procurement Agreement (JPA) is an innovative instrument for multi-country procurement of medical countermeasures against cross-border health threats. This paper aims to assess its potential performance. A literature review was conducted to identify key features of successful joint procurement programmes. Documentary analysis and a key informants' interview were carried out to analyse the European Union (EU) JPA. Ownership, equity, transparency, stable central financing, standardisation, flexibility and gradual development were identified as important prerequisites for successful establishment of multi-country joint procurement programmes in the literature while security of supply, favourable prices, reduction of operational costs and administrative burden and creation of professional expert networks were identified as desirable outcomes. The EU JPA appears to fulfil the criteria of ownership, transparency, equity, flexibility and gradual development. Standardisation is only partly fulfilled and central EU level financing is not provided. Security of supply is an important outcome for all EU Member States (MS). Price savings, reduction in administrative burden and creation of professional networks may be particularly attractive for the smaller MS. The JPA has the potential to increase health system collaboration and efficiency at EU level provided that the incentives for sustained commitment of larger MS are sufficiently attractive.
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In: Martakis, Kyriakos orcid:0000-0003-3982-0914 , Alexander, Denise, Schloemer, Tamara orcid:0000-0002-0219-4107 , Blair, Mitch orcid:0000-0001-7442-0188 , Rigby, Michael and Schroder-Back, Peter orcid:0000-0003-4496-3936 (2019). Human papillomavirus vaccination and respect for children's developing autonomy: Results from a European Union wide study. J. Child Health Care, 23 (3). S. 343 - 358. LONDON: SAGE PUBLICATIONS LTD. ISSN 1741-2889
Children's rights to autonomy of choice are differently expressed throughout Europe. We explored differences regarding expressions of respect for children's autonomy throughout Europe, using the procedure of human papillomavirus (HPV) vaccination offer as indicator. We used a mixed methods approach, utilizing an expert survey within the frame of Models of Child Health Appraised (MOCHA), among all 30 European Union (EU) and European Economic Area states. A questionnaire was designed using vignettes regarding the vaccine provision. Thirty MOCHA country agents were invited to respond from June 2017 to April 2018. In total, 28 country agents responded. We studied the following themes: (i) provision of informed consent, (ii) parental and medical paternalism, (iii) relevance of the child's chronological age or maturity, and (iv) vaccination programs targeting boys. These are being handled differently across the region. We explored associations of these implemented practices with the national vaccine coverage rate across Europe. We used the processes of HPV vaccination to study child's autonomy, the paradigm change toward libertarian paternalism and issues of sex-equity. Interestingly, greater respect for children's autonomy tends to be associated with medium or high vaccination coverage rates and lower respect with lower rates. Respect and empowerment seem to have practical as well as moral benefits. Identifying and transferring the most suitable ethical approaches is crucial and should be strengthened.
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In: Scholtes , B , Schroder-Back , P , Forster , K , MacKay , M , Vincenten , J & Brand , H 2017 , ' Multi-sectoral action for child safety-a European study exploring implicated sectors ' , European Journal of Public Health , vol. 27 , no. 3 , pp. 512-518 . https://doi.org/10.1093/eurpub/ckx010
Background: Injury to children in Europe, resulting in both death and disability, constitutes a significant burden on individuals, families and society. Inequalities between high and low-income countries are growing. The World Health Organisation Health 2020 strategy calls for inter-sectoral collaboration to address injury in Europe and advocates the whole of government and whole of society approaches to wicked problems. In this study we explore which sectors (e.g. health, transport, education) are relevant for four domains of child safety (intentional injury, water, road and home safety). Methods: We used the organigraph methodology, originally developed to demonstrate how organizations work, to describe the governance of child safety interventions. Members of the European Child Safety Alliance, working in the field of child safety in 24 European countries, drew organigraphs of evidence-based interventions. They included the different actors involved and the processes between them. We analyzed the organigraphs by counting the actors presented and categorizing them into sectors using a pre-defined analysis framework. Results: We received 44 organigraphs from participants in 24 countries. Twenty-seven sectors were identified across the four domains. Nine of the 27 identified sectors were classified as 'core sectors' (education, health, home affairs, justice, media, recreation, research, social/welfare services and consumers). Conclusions: This study reveals the multi-sectoral nature of child safety in practice. It provides information for stakeholders working in child safety to help them implement inter-sectoral child safety interventions taking a whole-of-government and whole-of-society approach to health governance.
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The efficiency and effectiveness of child safety interventions are determined by the quality of the implementation process. This multinational European study aimed to identify facilitators and barriers for the three phases of implementation: adoption, implementation and monitoring (AIM process). Twenty-seven participants from across the WHO European Region were invited to provide case studies of child safety interventions from their country. Cases were selected by the authors to ensure broad coverage of injury issues, age groups and governance level of implementation (eg, national, regional or local). Each participant presented their case and provided a written account according to a standardised template. Presentations and question and answer sessions were recorded. The presentation slides, written accounts and the notes taken during the workshops were analysed using thematic content analysis to elicit facilitators and barriers. Twenty-six cases (from 26 different countries) were presented and analysed. Facilitators and barriers were identified within eight general themes, applicable across the AIM process: management and collaboration; resources; leadership; nature of the intervention; political, social and cultural environment; visibility; nature of the injury problem and analysis and interpretation. The importance of the quality of the implementation process for intervention effectiveness, coupled with limited resources for child safety makes it more difficult to achieve successful actions. The findings of this study, divided by phase of the AIM process, provide practitioners with practical suggestions, where proactive planning might help increase the likelihood of effective implementation. ; Peer reviewed
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In: Schroder-Back, Peter orcid:0000-0003-4496-3936 , Schloemer, Tamara orcid:0000-0002-0219-4107 , Clemens, Timo, Alexander, Denise, Brand, Helmut orcid:0000-0002-2755-0673 , Martakis, Kyriakos orcid:0000-0003-3982-0914 , Rigby, Michael, Wolfe, Ingrid orcid:0000-0002-4717-7634 , Zdunek, Kinga orcid:0000-0001-9830-8115 and Blair, Mitch orcid:0000-0001-7442-0188 (2019). A Heuristic Governance Framework for the Implementation of Child Primary Health Care Interventions in Different Contexts in the European Union. Inquiry-J. Health Care Organ. Provis. Financ., 56. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1945-7243
To adopt and implement innovative good practices across the European Union requires developing policies for different political and constitutional contexts. Health policies are mostly decided by national political processes at different levels. To attain effective advice for policy making and good practice exchange, one has to take different models of governance for health into account. We aimed to explore which concepts of governance research are relevant for implementing child health policies in a European Union context. We argue that taking into account the insights of good intersectoral and multilevel governance in research and practice is essential and promising for future analyses. These governance concepts help to understand what actors and institutions are potentially of relevance for developing and implementing child-centric health care approaches not only within health care but also outside health care. The framework we developed has the potential to advise on and thus support effectively the spreading and implementation of good practices of child-centric health policy approaches across the European Union. With this heuristic framework, the variety of relevant stakeholders and institutions can better be mapped and taken into account in implementation processes. Also, the normative side-particularly stressing values that make governance good governance-is to be taken into account.
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