Optimisation of processing parameters for making pyrophyllite based ceramic tiles using di-sodium hydrogen phosphate binder
In: British ceramic transactions, Band 100, Heft 6, S. 279-283
ISSN: 1743-2766
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In: British ceramic transactions, Band 100, Heft 6, S. 279-283
ISSN: 1743-2766
In: British ceramic transactions, Band 102, Heft 2, S. 83-86
ISSN: 1743-2766
In: Climate policy, Band 20, Heft 4, S. 468-484
ISSN: 1752-7457
In May 2012, a Sarcopenia Consensus Summit was convened by the Foundation of the National Institutes of Health (FNIH), National Institute of Aging (NIA), and the U.S. Food and Drug Administration (FDA); and co-sponsored by five pharmaceutical companies. At this summit, sarcopenia experts from around the world worked to develop agreement on a working definition of sarcopenia, building on the work of previous efforts to generate a consensus. With the ultimate goal of improving function and independence in individuals with sarcopenia, the Task Force focused its attention on people at greatly increased risk of muscle atrophy as a consequence of hip fracture. The rationale for looking at this population is that since hip fracture is a recognized condition, there is a clear regulatory path forward for developing interventions. Moreover, patients with hip fracture may provide an appropriate population to advance understanding of sarcopenia, for example helping to define diagnostic criteria, develop biomarkers, understand the mechanisms that underlie the age-related loss of muscle mass and strength, and identify endpoints for clinical trials that are reliable, objective, and clinically meaningful. Task Force members agreed that progress in treating sarcopenia will require strengthening of partnerships between academia, industry, and government agencies, and across continents to reach consensus on diagnostic criteria, optimization of clinical trials design, and identification of improved treatment and preventive strategies. In this report, the main results of the Task Force discussion are presented.
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In: The journals of gerontology. Series A, Biological sciences, medical sciences, Band 68, Heft 1, S. 17-26
ISSN: 1758-535X
International audience ; —Hardware Trojans (HT) inserted in integrated circuits have received special attention of researchers. In this paper, we present firstly a novel HT detection technique based on path delays measurements. A delay model, which considers intra-die process variations, is established for a net. Secondly, we show how to detect HT using ElectroMagnetic (EM) measurements. We study the HT detection probability according to its size taking into account the inter-die process variations with a set of FPGA. The results show, for instance, that there is a probability greater than 95% with a false negative rate of 5% to detect a HT larger than 1.7% of the original circuit. I. Introduction The trust and security of Integrated Circuits (IC) design and fabrication is critical for sensitive fields like finance, health, and governmental communications. Due to the complexity and the high cost of IC fabrication cycle, more and more firms outsource their production. This trend gives a possibility for an adversary to introduce malicious circuit, called Hardware Trojan horse (HT), in any IC. It can either perform a Denial Of Service (DOS), deteriorate circuit performance [8], or steal sensitive information. Therefore, the HTs are considered a real threat which has gained attention from researchers. HT can be inserted at any point during the design or fabrication process from Register Transfer Level (RTL) to layout and circuit fabrication. For example in [11], authors show some techniques to insert malicious circuitry at RTL level. These HTs, which are activated with a specific pattern inputs, can leak secret key via RS232 channels. The HT, unlike a software trojan, cannot be removed once it is fabricated. So, it is better to proactively prevent the insertion of a HT: few methods have been proposed. One seminal work is known as " private circuits II " [9]. This paper describes a proof-of-concept, too costly to be implemented. A more reasonable option has been recently proposed in [5]: it uses two codes to encode the state and mix it with encoded randomness, which allows to prevent an easy triggering and has a detection capability. Otherwise it is important to detect it before it becomes effective. Previous works classify detection methods into two wide categories: destructive and non-destructive. Invasive methods destroy the chip to reconstruct successfully the GDSII and
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International audience ; —Hardware Trojans (HT) inserted in integrated circuits have received special attention of researchers. In this paper, we present firstly a novel HT detection technique based on path delays measurements. A delay model, which considers intra-die process variations, is established for a net. Secondly, we show how to detect HT using ElectroMagnetic (EM) measurements. We study the HT detection probability according to its size taking into account the inter-die process variations with a set of FPGA. The results show, for instance, that there is a probability greater than 95% with a false negative rate of 5% to detect a HT larger than 1.7% of the original circuit. I. Introduction The trust and security of Integrated Circuits (IC) design and fabrication is critical for sensitive fields like finance, health, and governmental communications. Due to the complexity and the high cost of IC fabrication cycle, more and more firms outsource their production. This trend gives a possibility for an adversary to introduce malicious circuit, called Hardware Trojan horse (HT), in any IC. It can either perform a Denial Of Service (DOS), deteriorate circuit performance [8], or steal sensitive information. Therefore, the HTs are considered a real threat which has gained attention from researchers. HT can be inserted at any point during the design or fabrication process from Register Transfer Level (RTL) to layout and circuit fabrication. For example in [11], authors show some techniques to insert malicious circuitry at RTL level. These HTs, which are activated with a specific pattern inputs, can leak secret key via RS232 channels. The HT, unlike a software trojan, cannot be removed once it is fabricated. So, it is better to proactively prevent the insertion of a HT: few methods have been proposed. One seminal work is known as " private circuits II " [9]. This paper describes a proof-of-concept, too costly to be implemented. A more reasonable option has been recently proposed in [5]: it uses two codes to encode ...
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Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9·1%] of 4521 in light restrictions, 317 [10·4%] of 3646 in moderate lockdowns, 2001 [23·8%] of 11 827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long-term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
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Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods This international, prospective, cohort study enrolled 20 006 adult (≥18 years) patients from 466 hospitals in 61 countries with 15 cancer types, who had a decision for curative surgery during the COVID-19 pandemic and were followed up until the point of surgery or cessation of follow-up (Aug 31, 2020). Average national Oxford COVID-19 Stringency Index scores were calculated to define the government response to COVID-19 for each patient for the period they awaited surgery, and classified into light restrictions (index 60). The primary outcome was the non-operation rate (defined as the proportion of patients who did not undergo planned surgery). Cox proportional-hazards regression models were used to explore the associations between lockdowns and non-operation. Intervals from diagnosis to surgery were compared across COVID-19 government response index groups. This study was registered at ClinicalTrials.gov, NCT04384926. Findings Of eligible patients awaiting surgery, 2003 (10·0%) of 20 006 did not receive surgery after a median follow-up of 23 weeks (IQR 16–30), all of whom had a COVID-19-related reason given for non-operation. Light restrictions were associated with a 0·6% non-operation rate (26 of 4521), moderate lockdowns with a 5·5% rate (201 of 3646; adjusted hazard ratio [HR] 0·81, 95% CI 0·77–0·84; p<0·0001), and full lockdowns with a 15·0% rate (1775 of 11 827; HR 0·51, 0·50–0·53; p<0·0001). In sensitivity analyses, including adjustment for SARS-CoV-2 case notification rates, moderate lockdowns (HR 0·84, 95% CI 0·80–0·88; p<0·001), and full lockdowns (0·57, 0·54–0·60; p<0·001), remained independently associated with non-operation. Surgery beyond 12 weeks from diagnosis in patients without neoadjuvant therapy increased during lockdowns (374 [9·1%] of 4521 in light restrictions, 317 [10·4%] of 3646 in moderate lockdowns, 2001 [23·8%] of 11827 in full lockdowns), although there were no differences in resectability rates observed with longer delays. Interpretation Cancer surgery systems worldwide were fragile to lockdowns, with one in seven patients who were in regions with full lockdowns not undergoing planned surgery and experiencing longer preoperative delays. Although short-term oncological outcomes were not compromised in those selected for surgery, delays and non-operations might lead to long-term reductions in survival. During current and future periods of societal restriction, the resilience of elective surgery systems requires strengthening, which might include protected elective surgical pathways and long- term investment in surge capacity for acute care during public health emergencies to protect elective staff and services. Funding National Institute for Health Research Global Health Research Unit, Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, Medtronic, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
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