Suchergebnisse

Our aim was to investigate the relation between PBDEs and fetal growth or newborn anthropometry in a Spanish cohort (2003-2008). PBDE congeners (BDE-47, -99, -153, -154, and -209) were determined in serum of 670 mothers at gestational week 12 and in 534 umbilical cord samples. Abdominal circumference (AC), estimated fetal weight (EFW), femur length (FL), and biparietal diameter (BPD) during gestation were measured by ultrasounds. At birth, weight (BW), head circumference (HC), and length (BL) were also measured. We assessed growth in the intervals between 12-20 and 20-34 weeks of gestation and size at birth by standard deviation (SD)-scores adjusted for constitutional characteristics. We conducted multivariate linear regression analyses between PBDE congeners and their sum (ΣPBDEs) and outcomes. We found statistically significant inverse associations between ΣPBDEs and AC, EFW, and BPD at weeks 20-34 and HC at birth. Regarding congeners, the association was clearer with BDE-99, with inverse associations being found with AC, EFW, and BPD at weeks 20-34, and with BW and HC at delivery. These outcomes decreased between 1.3% and 3.5% for each 2-fold PBDE increase. Concerning matrices, we found statistically significant inverse associations with BPD, HC, and BW when using maternal serum, and for AC and EFW with cord serum. In conclusion, PBDEs may impair fetal growth in late pregnancy and reduce birth size. © 2015 American Chemical Society. ; The authors are grateful to mothers who participated in the study and to San Agustin Hospital in Aviles and La Fe Hospital in Valencia. This work was supported by grants from the European Union (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), and grants from the Instituto de Salud Carlos III in Spain (Red INMA G03/176, CB06/02/0041, and FIS-FEDER PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI09/02311, PI11/01007, PI11/02591, PI11/02038, MS11/0178, PI13/1944, PI13/02429, PI14/00891, and PI14/01687), Conselleria de Sanitat of the Generalitat Valenciana, Obra Social Cajastur and University of Oviedo. ; Peer reviewed

[ES] Cada vez existe mayor evidencia de la influencia de la dieta y dela exposición a dosis bajas de tóxicos durante la etapa prenatal y primera infancia sobre la salud y el bienestar en etapas posteriores de lavida. Siguiendo las recomendaciones de la OMS y de la Unión Europea en el año 2003 se constituyó la Red de Investigación Cooperativa Infancia y Medio Ambiente para estudiar los efectos del medioambiente y la dieta en el desarrollo fetal e infantil en diversas zonas geográficas en España. La Red integra diversos grupos multidisciplinares de investigación y está constituida por seis cohortes, tres preexistentes y tres de novo, que seguirán de forma prospectiva a 3.600 mujeres embarazadas, desde el inicio del embarazo hasta los 46 años del niño. Los objetivos generales de la red son: (1) Describir la exposición individual a tóxicos ambientales durante la gestación y la primera infancia. (2) Evaluar los efectos de la exposición a tóxicos y de la dieta en el desarrollo fetal e infantil. (3) Evaluar la interacción entre factores tóxicos, nutricionales y genéticos en el desarrollo fetal e infantil. El seguimiento se realiza en cada trimestre de la gestación,al nacimiento, al año y hasta los cuatro o seis años del niño. La información se recoge mediante cuestionarios, datos clínicos, exploración física, ecografías, biomarcadores y mediciones ambientales. En este trabajo se presentan las caracterÌsticas generales de la red y se describe la situación actual de cada una de las cohortes. [EN] Increasingly greater evidence exists as to the influence which diet and exposure to low doses of toxic substances during the prenatal stage and early childhood has on health and well-being throughout later stages of life. Following the WHO and European Union recommendations in 2003, the Cooperative Environment and Childhood Research Network was set up to study the effects of the environment and diet on fetal and early childhood development in different geographical areas of Spain. This Network integrates different multidisciplinary research groups and is comprised of six cohorts--three pre-existing and three de novo--which will follow up prospectively 3,600 pregnant women, from the start of pregnancy up to age 4-6 years of the child. This network's general objectives are: (1) To describe individual exposure to toxic substances in the environment during gestation and early childhood. (2) To evaluate the effects of exposure to toxic substances and diet on fetal and early childhood development. (3) To evaluate the interaction among toxic, nutritional and genetic factors in fetal and early childhood development. The follow-up is done every three months during gestation, at birth, at age one and up to age four or six. The information is gathered by means of questionnaires, clinical data, physical examinations, echographs, biomarkers and environmental measurements. The general characteristics of the network and a description of the current situation of each one of the cohorts are provided in this study. ; Sí