Suchergebnisse

Objective: to understand the manner in which health education (HE) is taught at the National Faculty of Public Health (NFPH) of the University of Antioquia in Medellín, Colombia. Methodology: group and individual interviews with teachers, students and graduates. Likewise, the curricula of the Faculty'sacademic programs were reviewed. Results: The predominant approach is to teach HE as a tool or strategy conceived from the biomedical standpoint and grounded on a traditional/coercive pedagogical model. Furthermore, the teaching OF HE at the NFPH does not have the relevance that should be expected, which is a contradiction in itself. Disussion: the theoretical reflection developed proposes a different explanation: it isnot a contradiction; rather this situation pertains to a logical consequence of a public health perspective prevailing at the NFPH. The role of health education depends on the public health approach with which it is aligned. Other public health approaches are presented in which education has a basic and foundational sense and it is conceived from the point of view of alternative pedagogical models. So addressing HE teaching and defining the profile of public health professionals is not a neutral and technical issue for including certain topics. It is rather a consequence of a theoretical and political debate about the type of public health that should guide the curricula of academic programs and actions at the Faculty. ; Objetivo: comprender la enseñanza de la educación para la salud (EpS) en la Facultad Nacional de Salud Pública (FNSP) de la Universidad de Antioquia. Metodología: entrevistas grupales e individuales a profesores, estudiantes y egresados, así como con la revisión de los planes de estudio de los programas académicos de la Facultad. Resultados: es predominante la enseñanza de la EpS como herramienta o estrategia, concebida desde una perspectiva biomédica y fundada en un modelo pedagógico tradicional/coactivo; además, que la enseñanza de la EpS en la FNSP no tiene la relevancia que se esperaría, lo que aparentemente supone una contradicción. Discusión: La reflexión teórica realizada propone una salida diferente: esta situación, lejos de ser una contradicción, corresponde a una consecuencia lógica para una perspectiva de salud pública imperante en la FNSP. El papel que cumple la educación en la salud pública depende de la corriente en la cual se inscribe. Se presentan otras versiones de salud pública en las cuales la educación tiene un sentido básico y fundante y se plantea desde modelos pedagógicos alternativos. Así, abordar la enseñanza de la EpS y definir el perfil del salubrista no es un asunto neutral ni técnico para incluir ciertos contenidos; corresponde al producto de un debate teórico y político sobre la salud pública que debe orientar los currículos de los programas académicos y, en general, las acciones de la Facultad. ; Objetivo: compreensão do ensino da educação para a saúde (EPS) na Faculdade Nacional de Saúde Pública (FNSP) da Universidade de Antioquia. Metodologia: entrevistas grupais e individuais a professores, estudantes e ex-alunos, bem como com a revisão dos planos curriculares dos programas acadêmicos da Faculdade. Resultados: predominante o ensino da EPS como ferramenta ou estratégia, concebida desde uma perspectiva biomédica e fundada em um modelo pedagógico tradicional/coativo; além disso, que o ensino da EPS na FNSP não tem a relevância esperada, o que aparentemente supõe uma contradição. Discussão: A reflexão teórica realizada propõe uma saída diferente: esta situação, longe de ser uma contradição, corresponde a uma consequência lógica para uma perspectiva de saúde pública imperante na fnsp. O papel que desempenha a educação na saúde pública depende da corrente na qual se inscreve. Apresentam-se outras versões de saúde pública nas quais a educação tem um sentido básico e fundador e se propõe desde modelos pedagógicos alternativos. Assim, abordar o ensino da EPS e definir o perfil do profissional em saúde pública não é um assunto neutral nem técnico para incluir certos conteúdos; corresponde ao produto de um debate teórico e político sobre a saúde pública que deve guiar os currículos dos programas acadêmicos e, em geral, as ações da Faculdade.

In rheumatoid arthritis (RA), a key event is infiltration of inflammatory immune cells into the synovial lining, possibly aggravated by dysregulation of cellular adhesion molecules. Therefore, single nucleotide polymorphisms of 14 genes involved in cellular adhesion processes (CAST, ITGA4, ITGB1, ITGB2, PECAM1, PTEN, PTPN11, PTPRC, PXN, SELE, SELP, SRC, TYK2, and VCAM1) were analyzed for association with RA. Association analysis was performed consecutively in three European RA family sample groups (Nfamilies = 407). Additionally, we investigated differential allelic expression, a possible functional consequence of genetic variants. SELP (selectin P, CD62P) SNP-allele rs6136-T was associated with risk for RA in two RA family sample groups as well as in global analysis of all three groups (ptotal = 0.003). This allele was also expressed preferentially (p<10-6) with a two- fold average increase in regulated samples. Differential expression is supported by data from Genevar MuTHER (p1 = 0.004; p2 = 0.0177). Evidence for influence of rs6136 on transcription factor binding was also found in silico and in public datasets reporting in vitro data. In summary, we found SELP rs6136-T to be associated with RA and with increased expression of SELP mRNA. SELP is located on the surface of endothelial cells and crucial for recruitment, adhesion, and migration of inflammatory cells into the joint. Genetically determined increased SELP expression levels might thus be a novel additional risk factor for RA. ; The work presented in this paper was made possible by funding from the German Federal Ministry of Education and Research (BMBF, PtJ-Bio, 1315883, www.bmbf.de). This project was also supported by grant no. 7692/1187 from the Sa¨chsische Aufbaubank–Fo¨rderbank (www.sab.sachsen.de), by grant no. 4212/ 04-04 from the European Fund for Regional Development (EFRE, ec.europa.eu), by the German Federal Ministry for Education and Research (Hochschul- und Wissenschaftsprogramm; ''Kompetenznetz Rheuma'' 01GI9949 to IM), by the Rosa-Luxemburg-Stiftung (www.rosalux.de) and by the Foundation for Science and Technology, Portugal (grant SFRH/BD/23304/2005, www.fct.pt). PA, MS and HK were also supported by LIFE – Leipzig Research Center for Civilization Diseases (life.uni-leipzig.de), Universita¨t Leipzig. LIFE is funded by means of the European Union, by the European Regional Development Fund (ERDF) and by means of the Free State of Saxony within the framework of the excellence initiative.