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This guide is designed primarily for officials in central government departments who may be involved in the handling of FOIA requests, but who are not FOIA specialists. It is intended to offer a succinct and easy-to-use introduction to the FOIA and to be complementary to more detailed official advice which will be available from the Home Office and the Information Commissioner. The public will expect public authorities: To know about FOI; To follow the set procedures; To be helpful in overcoming problems; To disclose information. It covers the essential information you need to know about the Act, and gives guidance on what you need to do in normal situations to apply it. It cannot, however, replace the need to take legal advice, as appropriate, on the proper application of the Act.

The study described in this paper is part of a project assessing the impact of the HIV epidemic on 535 men who have sex with men. These men were surveyed about their knowledge of HIV, their sexual practices, other issues concerning the transmission of HIV, and AIDS. This paper focuses on these men's beliefs about HIV transmission, their perceptions of the safety of a number of sexual and social practices, and the factors influencing these perceptions. The findings indicate, in general, that the men surveyed were moderately well informed about HIV transmission. Some twenty percent of the men were well‐informed about both 'safe' and 'unsafe' sexual practices, a small number were ill‐informed and the remainder, the majority, were well‐informed about some aspects and ill‐informed about others. The data suggest that information from the mainstream and gay press is not only differentially available but that information is processed and interpreted by the men in different ways. Variables which influence the manner in which information is interpreted are place of residence (locale), awareness of gay community posters and pamphlets, and the men's sexual practice; these are associated with cautiousness or rashness in the men's judgments of safety and risk.

New data are reported from a second run of the 2-liter PICO-2L C3F8 bubble chamber with a total exposure of 129 kg-days at a thermodynamic threshold energy of 3.3 keV. These data show that measures taken to control particulate contamination in the superheated fluid resulted in the absence of the anomalous background events observed in the first run of this bubble chamber. One single nuclear-recoil event was observed in the data, consistent both with the predicted background rate from neutrons and with the observed rate of unambiguous multiple-bubble neutron scattering events. The chamber exhibits the same excellent electron-recoil and alpha decay rejection as was previously reported. These data provide the most stringent direct detection constraints on weakly interacting massive particle (WIMP)-proton spin-dependent scattering to date for WIMP masses 50 GeV/c(2). ; The PICO Collaboration thanks SNOLAB for their exceptional laboratory space and technical support. We also thank Fermi National Accelerator Laboratory (Contract No. DE-AC02-07CH11359) and Pacific Northwest National Laboratory for their support. This work is supported by the National Sciences and Engineering Research Council of Canada (NSERC), the Canada Foundation for Innovation (CFI), the National Science Foundation (NSF) under the Grants No. PHY-1242637, No. PHY-0919526, No. PHY-1205987, and No. PHY-1506377 and by the U.S. Department of Energy under Award No. DE-SC-0012161. We also acknowledge the support of Department of Atomic Energy (DAE), Government of India, under the Center of AstroParticle Physics II project (CAPP-II) at Saha Institute of Physics (SINP); the Czech Ministry of Education, Youth and Sports (Grant No. LM2011027); the Spanish Ministerio de Economia y Competitividad, Consolider MultiDark (Grant No. CSD2009-00064) and DGAPA-UNAM through grant PAPIIT No. IA100316. ; Amole, C.; Ardid Ramírez, M.; Arnquist, I.; Asner, DM.; Baxter, D.; Behnke, E.; Bhattacharjee, P. (2016). Improved dark matter search results from PICO-2L Run 2. Physical ...

1 14 93 5 ; S ; New data are reported from the operation of the PICO-60 dark matter detector, a bubble chamber filled with 36.8 kg of CF3I and located in the SNOLAB underground laboratory. PICO-60 is the largest bubble chamber to search for dark matter to date. With an analyzed exposure of 92.8 livedays, PICO-60 exhibits the same excellent background rejection observed in smaller bubble chambers. Alpha decays in PICO-60 exhibit frequency-dependent acoustic calorimetry, similar but not identical to that reported recently in a C3F8 bubble chamber. PICO-60 also observes a large population of unknown background events, exhibiting acoustic, spatial, and timing behaviors inconsistent with those expected from a dark matter signal. These behaviors allow for analysis cuts to remove all background events while retaining 48.2% of the exposure. Stringent limits on weakly interacting massive particles interacting via spin-dependent proton and spin-independent processes are set, and most interpretations of the DAMA/LIBRA modulation signal as dark matter interacting with iodine nuclei are ruled out. The PICO Collaboration would like to thank SNOLAB and its staff for providing an exceptional underground laboratory space and invaluable technical support. We acknowledge technical assistance from Fermilab's Computing, Particle Physics, and Accelerator Divisions and from A. Behnke at IUSB. We thank V. Gluscevic and S. McDermott for useful conversations and their assistance with the DMDD code package. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of High Energy Physics under Award No. DE-SC-0012161. Fermi National Accelerator Laboratory is operated by Fermi Research Alliance, LLC under Contract No. De-AC02-07CH11359. Part of the research described in this paper was conducted under the Ultra Sensitive Nuclear Measurements Initiative at Pacific Northwest National Laboratory, a multiprogram national laboratory operated by Battelle for the U.S. Department of Energy. We acknowledge ...

Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, and organism-level physiological changes. Identification of these signals could aid in diagnostics, treatment decision-making, and risk evaluation. In the search for PTSD diagnostic biomarkers, we ascertained over one million molecular, cellular, physiological, and clinical features from three cohorts of male veterans. In a discovery cohort of 83 warzone-related PTSD cases and 82 warzone-exposed controls, we identified a set of 343 candidate biomarkers. These candidate biomarkers were selected from an integrated approach using (1) data-driven methods, including Support Vector Machine with Recursive Feature Elimination and other standard or published methodologies, and (2) hypothesis-driven approaches, using previous genetic studies for polygenic risk, or other PTSD-related literature. After reassessment of ~30% of these participants, we refined this set of markers from 343 to 28, based on their performance and ability to track changes in phenotype over time. The final diagnostic panel of 28 features was validated in an independent cohort (26 cases, 26 controls) with good performance (AUC = 0.80, 81% accuracy, 85% sensitivity, and 77% specificity). The identification and validation of this diverse diagnostic panel represents a powerful and novel approach to improve accuracy and reduce bias in diagnosing combat-related PTSD.