Suchergebnisse

Intro -- Title Page -- Foreword -- Preface -- One: Born of Mary -- Two: Miracle Worker -- Three: Teacher of Love for God and Neighbor -- Four: Proclaimer of the Kingdom of God -- Five: Jesus, Word and Spirit of God -- Six: Jesus Son of Mary, Son of Man -- Seven: Son of God -- Eight: Jesus Messiah and Redeemer -- Nine: Raised from Death -- Ten: Returning in Power -- Bibliography.

The estimation of substitution and recombination rates can provide important insights into the molecular evolution of protein-coding sequences. Here, we present a new computational framework, called "CodABC," to jointly estimate recombination, substitution and synonymous and nonsynonymous rates from coding data. CodABC uses approximate Bayesian computation with and without regression adjustment and implements a variety of codon models, intracodon recombination, and longitudinal sampling. CodABC can provide accurate joint parameter estimates from recombining coding sequences, often outperforming maximum-likelihood methods based on more approximate models. In addition, CodABC allows for the inclusion of several nuisance parameters such as those representing codon frequencies, transition matrices, heterogeneity across sites or invariable sites. CodABC is freely available from http://code.google.com/p/codabc/, includes a GUI, extensive documentation and ready-to-use examples, and can run in parallel on multicore machines. ; This work was supported by the Spanish Government with the "Juan de la Cierva" fellowship JCI-2011-10452 to M.A., the European Research Council (ERC Grant Agreement No. 617457) to D.P., and Fundac¸~ao para a Ci^encia e a Tecnologia (FCT) (grant EXCL/BIA-ANM/0549/2012) to J.S.L. ; Peer reviewed