When we imagine life behind the high walls of the fortress-like prisons that were built and modified as the modern prison system was created in the mid-nineteenth century, we conjure up scenes where strict regulation prevailed to control people in body and in mind. An image that poses something of a paradox is that of mothers and their babies living in this carceral environment. This book looks behind the cell doors of these institutions to illuminate the experiences of this group of prisoners. The management of their health alongside the management of penal discipline posed complex conundrums to the prison system. Although rarely fully considered at policy level, this balancing act was negotiated by those who lived and worked in prisons on a daily basis
The book is the first extensive historical examination of motherhood in English prisons. It addresses the challenges mothers and babies have historically posed to prison systems not designed with their containment and the management of their health in mind
In recent years, there has been an increasing interest in the pathophysiology of repetitive concussive traumatic brain injury (rcTBI) in large part due to the association with dramatic cases of progressive neurological deterioration in professional athletes, military personnel, and others. However, our understanding of the pathophysiology of rcTBI is less advanced than for more severe brain injuries. Most prominently, the mechanisms underlying traumatic axonal injury, microglial activation, amyloid-beta accumulation, and progressive tau pathology are not yet known. In addition, the role of injury to dendritic spine cytoskeletal structures, vascular reactivity impairments, and microthrombi are intriguing and subjects of ongoing inquiry. Methods for quantitative analysis of axonal injury, dendritic injury, and synaptic loss need to be refined for the field to move forward in a rigorous fashion. We and others are attempting to develop translational approaches to assess these specific pathophysiological events in both animals and humans to facilitate clinically relevant pharmacodynamic assessments of candidate therapeutics. In this article, we review and discuss several of the recent experimental results from our lab and others. We include new initial data describing the difficulty in modeling progressive tau pathology in experimental rcTBI, and results demonstrating that sertraline can alleviate social interaction deficits and depressive-like behaviors following experimental rcTBI plus foot shock stress. Furthermore, we propose a discrete set of open, experimentally tractable questions that may serve as a framework for future investigations. In addition, we also raise several important questions that are less experimentally tractable at this time, in hopes that they may stimulate future methodological developments to address them.
