Suchergebnisse

Significant progress in environmental flow management has occurred in recent years due to several factors. These include governments committing to environmental flow programs, significant progress in scientific understanding, and environmental flow assessment methods that are cognizant of stakeholder participation and co-design. However, there remain key challenges facing environmental water management. In this paper, we report on a horizon scanning exercise that identified the questions, which, if answered, would deliver much needed progress in the field of environmental water management. We distributed an online survey to ask researchers and practitioners in the field of environmental water management to identify the key questions. The authors then consolidated 268 submitted questions and organized them into key themes. The consolidated list was presented to a workshop of environmental water researchers and practitioners, where attendees were asked to review the questions, vote on the most important, and provide feedback on gaps, issues, or overlaps. The breadth of issues facing environmental water management is captured by the six key themes into which questions were classified: (1) Ecological knowledge and environmental flow assessment methods, (2) Adaptive management, (3) Integrated management and river objectives, (4) Knowledge transfer: applying best practice in a global context, (5) Community knowledge and engagement, and (6) Active management. These questions provide a roadmap for research and management innovations that will improve the effectiveness of environmental flows programs. ; Full Text

Significant progress in environmental flow management has occurred in recent years due to several factors. These include governments committing to environmental flow programs, significant progress in scientific understanding, and environmental flow assessment methods that are cognizant of stakeholder participation and co-design. However, there remain key challenges facing environmental water management. In this paper, we report on a horizon scanning exercise that identified the questions, which, if answered, would deliver much needed progress in the field of environmental water management. We distributed an online survey to ask researchers and practitioners in the field of environmental water management to identify the key questions. The authors then consolidated 268 submitted questions and organized them into key themes. The consolidated list was presented to a workshop of environmental water researchers and practitioners, where attendees were asked to review the questions, vote on the most important, and provide feedback on gaps, issues, or overlaps. The breadth of issues facing environmental water management is captured by the six key themes into which questions were classified: (1) Ecological knowledge and environmental flow assessment methods, (2) Adaptive management, (3) Integrated management and river objectives, (4) Knowledge transfer: applying best practice in a global context, (5) Community knowledge and engagement, and (6) Active management. These questions provide a roadmap for research and management innovations that will improve the effectiveness of environmental flows programs.

Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (i.e., nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. Currently, the driver for this progression is not fully understood; in particular, it is not known how NAFLD and its early progression affects the distribution of lipids in the liver, producing lipotoxicity and inflammation. In this study, we used dietary and genetic mouse models of NAFL and NASH and translated the results to humans by correlating the spatial distribution of lipids in liver tissue with disease progression using advanced mass spectrometry imaging technology. We identified several lipids with distinct zonal distributions in control and NAFL samples and observed partial to complete loss of lipid zonation in NASH. In addition, we found increased hepatic expression of genes associated with remodeling the phospholipid membrane, release of arachidonic acid (AA) from the membrane, and production of eicosanoid species that promote inflammation and cell injury. The results of our immunohistochemistry analyses suggest that the zonal location of remodeling enzyme LPCAT2 plays a role in the change in spatial distribution for AA-containing lipids. This results in a cycle of AA-enrichment in pericentral hepatocytes, membrane release of AA, and generation of proinflammatory eicosanoids and may account for increased oxidative damage in pericentral regions in NASH. CONCLUSION: NAFLD is associated not only with lipid enrichment, but also with zonal changes of specific lipids and their associated metabolic pathways. This may play a role in the heterogeneous development of NAFLD. (Hepatology 2017;65:1165-1180). ; Medical Research Council (MRC). Horizon 2020 Framework Program of the European Union.