Modification of aflatoxin B1 and ochratoxin A toxicokinetics in rats administered a yeast cell wall preparation
International audience The cell wall of Saccharomyces cerevisiae can bind mycotoxins in vitro but there is scarce information on whether this property decreases the absorption of mycotoxins in vivo. The effect of a yeast cell wall preparation (YCW) on toxicokinetics and balance excretion (urine and faeces) of aflatoxin B1 (AFB1) and ochratoxin A (OTA) was tested in rats after oral administration of each toxin. The 3H-labelled mycotoxins were used at low doses. Co-administration of YCW with AFB1 decreased the extent but not the rate of absorption. Concurrently, radioactivity excreted in faeces increased by up to 55% when compared to controls, whilst the excretion in urine decreased (p OTA). In conclusion, these results indicate that YCW could be used to protect monogastric animals against exposure to low dietary levels of selected mycotoxins.
