Chronic exposures to low and high concentrations of ibuprofen elicit different gene response patterns in a euryhaline fish
In: Environmental science and pollution research: ESPR, Band 22, Heft 22, S. 17397-17413
ISSN: 1614-7499
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In: Environmental science and pollution research: ESPR, Band 22, Heft 22, S. 17397-17413
ISSN: 1614-7499
Modern toxicology is evolving to leverage data science methodologies to better address complex public health and environmental concerns. Understanding the potential adverse impacts of environmental exposures requires working across a variety of domains and data types that are often siloed and require manual curation and extraction. Ontologies and semantic engineering can facilitate meaningful data integration, but existing semantic standards have not been widely used in toxicology. Development of semantic standards for toxicology requires sustained interdisciplinary collaborations. One place where the community came together to discuss this need is the "Computable Exposures" workshop, held at Oregon State University in September 2019. Ontologists, toxicologists, epidemiologists, exposure scientists, ecotoxicologists, clinicians, computer scientists, computational biologists, and data scientists from academia, government, and industry were in attendance. Here we describe community-building efforts, standards development, and plans for future work. Objectives include building a semantic exposure data model using the Environmental Conditions, Treatments, and Exposures Ontology (ECTO), developing toxicology-driven use cases and competency questions, creating a mailing list, and planning a larger computable exposures conference. Twelve use cases were developed during the workshop, for example, using semantic technology to complete Adverse Outcomes Pathway (AOP) and Aggregate Exposure Pathway (AEP) given the initiating and terminal key events. Broader adoption of ontologies, together with increased data sharing, has the potential to improve a toxicologist's ability to integrate, navigate, and analyze vast amounts of heterogeneous data—allowing for more rapid safety assessment of chemical and environmental exposures, and increased understanding of underlying biological mechanisms across species.
BASE
International audience ; The ubiquitous pollution of the environment with microplastics, a diverse suite of contaminants, is of growing concern for science and currently receives considerable public, political, and academic attention. The potential impact of microplastics in the environment has prompted a great deal of research in recent years. Many diverse methods have been developed to answer different questions about microplastic pollution, from sources, transport, and fate in the environment, and about effects on humans and wildlife. These methods are often insufficiently described, making studies neither comparable nor reproducible. The proliferation of new microplastic investigations and cross-study syntheses to answer larger scale questions are hampered. This diverse group of 23 researchers think these issues can begin to be overcome through the adoption of a set of reporting guidelines. This collaboration was created using an open science framework that we detail for future use. Here, we suggest harmonized reporting guidelines for microplastic studies in environmental and laboratory settings through all steps of a typical study, including best practices for reporting materials, quality assurance/quality control, data, field sampling, sample preparation, microplastic identification, microplastic categorization, microplastic quantification, and considerations for toxicology studies. We developed three easy to use documents, a detailed document, a checklist, and a mind map, that can be used to reference the reporting guidelines quickly. We intend that these reporting guidelines support the annotation, dissemination, interpretation, reviewing, and synthesis of microplastic research. Through open access licensing (CC BY 4.0), these documents aim to increase the validity, reproducibility, and comparability of studies in this field for the benefit of the global community.
BASE
International audience ; The ubiquitous pollution of the environment with microplastics, a diverse suite of contaminants, is of growing concern for science and currently receives considerable public, political, and academic attention. The potential impact of microplastics in the environment has prompted a great deal of research in recent years. Many diverse methods have been developed to answer different questions about microplastic pollution, from sources, transport, and fate in the environment, and about effects on humans and wildlife. These methods are often insufficiently described, making studies neither comparable nor reproducible. The proliferation of new microplastic investigations and cross-study syntheses to answer larger scale questions are hampered. This diverse group of 23 researchers think these issues can begin to be overcome through the adoption of a set of reporting guidelines. This collaboration was created using an open science framework that we detail for future use. Here, we suggest harmonized reporting guidelines for microplastic studies in environmental and laboratory settings through all steps of a typical study, including best practices for reporting materials, quality assurance/quality control, data, field sampling, sample preparation, microplastic identification, microplastic categorization, microplastic quantification, and considerations for toxicology studies. We developed three easy to use documents, a detailed document, a checklist, and a mind map, that can be used to reference the reporting guidelines quickly. We intend that these reporting guidelines support the annotation, dissemination, interpretation, reviewing, and synthesis of microplastic research. Through open access licensing (CC BY 4.0), these documents aim to increase the validity, reproducibility, and comparability of studies in this field for the benefit of the global community.
BASE
The ubiquitous pollution of the environment with microplastics, a diverse suite of contaminants, is of growing concern for science and currently receives considerable public, political, and academic attention. The potential impact of microplastics in the environment has prompted a great deal of research in recent years. Many diverse methods have been developed to answer different questions about microplastic pollution, from sources, transport, and fate in the environment, and about effects on humans and wildlife. These methods are often insufficiently described, making studies neither comparable nor reproducible. The proliferation of new microplastic investigations and cross-study syntheses to answer larger scale questions are hampered. This diverse group of 23 researchers think these issues can begin to be overcome through the adoption of a set of reporting guidelines. This collaboration was created using an open science framework that we detail for future use. Here, we suggest harmonized reporting guidelines for microplastic studies in environmental and laboratory settings through all steps of a typical study, including best practices for reporting materials, quality assurance/quality control, data, field sampling, sample preparation, microplastic identification, microplastic categorization, microplastic quantification, and considerations for toxicology studies. We developed three easy to use documents, a detailed document, a checklist, and a mind map, that can be used to reference the reporting guidelines quickly. We intend that these reporting guidelines support the annotation, dissemination, interpretation, reviewing, and synthesis of microplastic research. Through open access licensing (CC BY 4.0), these documents aim to increase the validity, reproducibility, and comparability of studies in this field for the benefit of the global community.
BASE