Suchergebnisse

Hauptbeschreibung: Die »Fälle und Lösungen zum Allgemeinen Teil des BGB« sind eine Hilfe bei der Wiederholung und Vertiefung des Rechtsgebietes. Nach einer anschaulichen Einführung in die Fallbearbeitung werden 10 ausgewählte Fälle mit Lösungsvorschlägen dargestellt

The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the disease. In a search for a drug against COVID-19, we have performed a high-throughput X-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for viral replication. In contrast to commonly applied X-ray fragment screening experiments with molecules of low complexity, our screen tested already approved drugs and drugs in clinical trials. From the three-dimensional protein structures, we identified 37 compounds that bind to Mpro. In subsequent cell-based viral reduction assays, one peptidomimetic and six non-peptidic compounds showed antiviral activity at non-toxic concentrations. We identified two allosteric binding sites representing attractive targets for drug development against SARS-CoV-2.