Suchergebnisse

This is a detailed study of understanding in a second language, related to the actual lives of minority workers. The focus is on everyday interactions between these workers and the bureaucrats of the society in which they are now resident. It provides an important contribution to the debate about the function of language as a social practice, adding a new perspective to the psycholinguistic and experimental paradigms, currently existing in second language acquisition research

Finanzielle Unabhängigkeit ist wichtiger Bestandteil eines selbstbestimmten Lebens. Trotzdem scheinen Finanzen und Geldanlagen in der öffentlichen Wahrnehmung immer noch eher Männersache zu sein. Viele Frauen wissen einfach nicht, wo sie anfangen sollen IBM und wen sie um Rat fragen können. Der Finanzheldinnen-Planer möchte Frauen dazu bringen, sich mit ihren Finanzen auseinanderzusetzen und sie so in die finanzielle Unabhängigkeit begleiten. Er geht im Ausfüllteil Schritt für Schritt die wichtigen Fragen durch: Wie ist die aktuelle finanzielle Situation? Welche Ziele gibt es? Und welche Budget-Töpfe können bei der Planung helfen? Im Anschluss geht es an den Vermögensaufbau. Dazu gibt es allgemeine Tipps zum Thema Geld IBM vom Erstellen eines Haushaltsbuches, über die Gehaltsverhandlung, bis hin zur konkreten Anleitung für den ersten Wertpapierkauf. (Verlagstext)

European Union ; Academy of Finland ; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Finnish Cultural Foundation ; Tampere University Hospital Medical Research Fund ; Sigrid Juselius Foundation ; European Union: GA328988 ; European Union: 232738 ; Academy of Finland: 283157 ; Academy of Finland: 272376 ; Processo FAPESP: 2014/02253-6 ; Processo FAPESP: 2015/02174-1 ; Processo FAPESP: 2016/00013-3 ; The alternative respiratory chain (aRC), comprising the alternative NADH dehydrogenases (NDX) and quinone oxidases (AOX), is found in microbes, fungi and plants, where it buffers stresses arising from restrictions on electron flow in the oxidative phosphorylation system. The aRC enzymes are also found in species belonging to most metazoan phyla, including some chordates and arthropods species, although not in vertebrates or in Drosophila. We postulated that the aRC enzymes might be deployed to alleviate pathological stresses arising from mitochondria! dysfunction in a wide variety of disease states. However, before such therapies can be contemplated, it is essential to understand the effects of aRC enzymes on cell metabolism and organismal physiology. Here we report and discuss new findings that shed light on the functions of the aRC enzymes in animals, and the unexpected benefits and detriments that they confer on model organisms. In Clone intestinalis, the aRC is induced by hypoxia and by sulfide, but is unresponsive to other environmental stressors. When expressed in Drosophila, AOX results in impaired survival under restricted nutrition, in addition to the previously reported male reproductive anomalies. In contrast, it confers cold resistance to developing and adult flies, and counteracts cell signaling defects that underlie developmental dysmorphologies. The aRC enzymes may also influence life span and stress resistance more generally, by eliciting or interfering with hormetic mechanisms. In sum, their judicious use may lead to major benefits in medicine, but this will require a thorough characterization of their properties and physiological effects.