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The present work is an investigation of the biological response to the presence of grooves 3 µm deep, 15 µm wide and spaced by 100 µm, produced with femtosecond laser on ß-tricalcium phosphate (ß-TCP). The heat affected zone generated by the laser irradiation was investigated. Micro-Raman spectroscopy showed a transformation from ß-TCP phase into a-TCP phase, localised inside the grooves. The X Ray Diffraction analyses, correlated with micro-Raman data, confirmed that the use of femtosecond pulsed laser enables to limit the thermal impact. A selection of optimised process parameters allowed to obtain ß-TCP micro-patterned surfaces avoiding any phase transformation. The increase of the wettability with the micro-patterning, compared to smooth surfaces, was highlighted. An improvement of the osteoblastic proliferation was also demonstrated. Finally, the tendency of cell elongation along the grooves direction showed the ability of osteoblastic cells to adapt their morphology to the support topography on which they grow. ; The authors are grateful to the JECS Trust for funding the visit of Marie Lasgorceix to the Laboratory INEB (Contract N°2015106). Marie Lasgorceix also acknowledges the Walloon Region for financial support, within the "BEWARE" program (convention n°1510392) co-funded by Wallonia and European Union (FP7 – Marie Curie Actions) . The authors are grateful to Dr Sylvain Desprez (Materia Nova, Mons, Belgium) for micro-Raman analyses. This publication is based on the work of COST Action MP1301, funded by COST (European Cooperation in Science and Technology) www.cost.eu .

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p <.05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p <.0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen's ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than.20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above.10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.