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PurposeThis paper aims to present a methodology for technological foresight and technological scanning based on S&T and knowledge indicators.Design/methodology/approachThis proposal considers S&T and knowledge indicators, such as a patents indicator (technology), research and development indicator (science) and competencies indicator (human resources). International databases and a data‐and text‐mining tool are used to build up knowledge maps and reference tables to support decision making.FindingsThis study provides information about the use of technological foresight and technological scanning using the biotechnology in the health sector as a case study. In this paper, the trends observed in patents and articles worldwide clearly show the growth in biotechnology, which points to the need to prioritize this area, as well as opening up a variety of opportunities, especially when one considers the human competencies already consolidated in Brazilian universities and research institutes, which could be better harnessed by industry and could help ensure greater innovation and competitiveness.Originality/valueThe paper presents a methodology for the effective support of decision taking during the prioritization of strategic and/or technological areas by visualizing potential markets and partnership opportunities. Furthermore, it emphasizes the role of biotechnology as a catalyst for S&T and innovations in the world.