Suchergebnisse

This volume gives an in-depth account of cultural heritage of Nagaland covering important themes like cultural beliefs, traditional knowledge, material culture, and social institutions. Contributors from diverse dis ciplines and backgrounds have delved into the cultural heritage of the state's variegated tribes. Nagaland a hilly state in North-East India had been the centre of British colonialism and American Baptist mission. This cultural contact is significantly reflected in the socio-cultural life, and the contributors have shed light on the continuities and changes. This volume highlights the multiplicity of cultural traditions that are specific to various tribes inhabiting sixteen districts of Nagaland, since their experiences of modernity and cultural contact with 'others' have been diverse.The contributors have mainly focussed on the cultural heritage of the majority Naga tribes, but other tribes like the Kukis and Kacharis are part and parcel of the cultural melting pot of Nagaland, and this volume in a way underscores the cultural exchange and interactions.Taylor & Francis does not sell or distribute the print version of this book in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka

Verlagsinfo: This book is an outcome of the National Seminar organized by IGRMS in collaboration with the Department of Anthropology, Gauhati University, Guwahati, Assam. The volume comprises of 29 articles presented in the conference and dealt with the issues related with the various crucial aspects of the theme. The volume generates a vide understanding about the rich cultural heritage of Assam. In fact, the domain of cultural heritage in the context of Assam is very vast; however, this book tries to focus on some of the areaswhich deserve attention from the contemporary perspective. The book will be of immense interest to scholars and students of Anthropology, Sociology and Cultural studies and may lead to new researches to understand the people and the places of India's North east. ABOUT THE AUTHOR:- Prof. Sarit K. Chaudhuri is the Director of National Museum of Mankind (IGRMS), Bhopal, under Ministry of Culture, Govt. of India. During 2003-05, as a postdoctoral fellow of SOAS, UK, he worked in a five years collaborative project of SOAS, British Museum, CCRD, and Rajiv Gandhi University, Arunachal Pradesh. He also worked with An SI, Shillong, as well as with Rajiv Gandhi University, Arunachal Pradesh in the Department of Anthropology and AITS. He has published 9 books and 52 research papers. Currently he is the editor of Humankind an annual IGRMS journal and also member of the 'Think Tank' formed by the Ministry of Culture, Government of India. Mini Bhattacharyya Thakur has been a faculty member in the Department of Anthropology, Gauhati University since 1988. Presently she is a professor and head of department. She has a brilliant academic record and received her Masters' Degree from Delhi University and completed her Doctoral work on "Street food in urban Guwahati: An Anthropological Appraisal" under the supervision of Dr. A.C. Bhagabati of Gauhati University. Her research interests include food studies, medical anthropology and tribal development.

A historian/anthropologist amongst the Garos of Bangladesh / Ellen Bal -- Power and authority in the field / Ali Khan -- Story of my research in Bhutan / A.C. Sinha -- Remembering fieldwork histories / Mandy Sadan -- Fields of working knowledge / Ben Campbell -- Reflections on fieldwork in three cultures / Arjun Guneratne -- Return to Rengsanggri / Robbins Burling -- Researching Garo death rites / Erik de Maaker -- Memories and reflections on ethnographic fieldwork in "conflict" setting / Debojyoti Das -- In search of storytellers among the Khiamniungan Nagas / Anungla Aier -- Experiencing mortuary practices in an anthropological journey / Gautam Kumar Bera -- Making senses of the organizations and the experiences of anthropological practices in a university of India / Arnab Das -- Tales of everyday politics in West Bengal / Suman Nath and Bhaskar Chakrabarti -- Doing fieldwork and discovering Harijan art in Madhubani / Neel Rekha -- Memories of my third visit to the Nicobar archipelago / Vijoy S. Sahay -- Discovering the self and others in Jammu, Kashmir, and Ladakh / Abeer Gupta -- Dialogue on indigenous studies and fieldwork in India / Daniel J. Rycroft and Ganesh Devy

Protein kinase C (PKC) isozymes play major roles in human diseases, including cancer. Yet, the poor understanding of isozymes-specific functions and the limited availability of selective pharmacological modulators of PKC isozymes have limited the clinical translation of PKC-targeting agents. Here, we report the first small-molecule PKCd-selective activator, the 7a-acetoxy-6ß-benzoyloxy-12-O-benzoylroyleanone (Roy-Bz), which binds to the PKCd-C1-domain. Roy-Bz potently inhibited the proliferation of colon cancer cells by inducing a PKCd-dependent mitochondrial apoptotic pathway involving caspase-3 activation. In HCT116 colon cancer cells, Roy-Bz specifically triggered the translocation of PKCd but not other phorbol ester responsive PKCs. Roy-Bz caused a marked inhibition in migration of HCT116 cells in a PKCd-dependent manner. Additionally, the impairment of colonosphere growth and formation, associated with depletion of stemness markers, indicate that Roy-Bz also targets drug-resistant cancer stem cells, preventing tumor dissemination and recurrence. Notably, in xenograft mouse models, Roy-Bz showed a PKCd-dependent antitumor effect, through anti-proliferative, pro-apoptotic, and anti-angiogenic activities. Besides, Roy-Bz was non-genotoxic, and in vivo it had no apparent toxic side effects. Collectively, our findings reveal a novel promising anticancer drug candidate. Most importantly, Roy-Bz opens the way to a new era on PKC biology and pharmacology, contributing to the potential redefinition of the structural requirements of isozyme-selective agents, and to the re-establishment of PKC isozymes as feasible therapeutic targets in human diseases. ; We thank European Union (FEDER funds POCI/01/0145/FEDER/007728, FCOMP-01-0124-FEDER-028417 and POCI-01-0145-FEDER-007440, through Programa Operacional Factores de Competitividade—COMPETE) and National Funds (FCT/MEC, Fundação para a Ciência e Tecnologia and Ministério da Educação e Ciência) under the Partnership Agreement PT2020 UID/MULTI/ 04378/2013, UID/NEU/04539/2013, UID/DTP/04567/2016, and the project (3599-PPCDT) PTDC/DTP-FTO/1981/2014—POCI-01-0145-FEDER-016581, as well as Centro 2020 Regional Operational Programmes (CENTRO-01-0145-FEDER-000012: HealthyAging2020). FCT fellowships: SFRH/BD/87109/2012 (C. Bessa), SFRH/BD/117949/2016 (L. Raimundo), and SFRH/BD/128673/2017 (J. B. Loureiro).