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In: Plains anthropologist, Band 48, Heft 185, S. 5-9
ISSN: 2052-546X
A Shell Mask Gorget from Allamakee County, Low a
In: Plains anthropologist, Band 40, Heft 153, S. 251-260
ISSN: 2052-546X
Introduction
In: Plains anthropologist, Band 48, Heft 185, S. 1-4
ISSN: 2052-546X
Should Congress decriminalize marijuana? [opposing views]
In: American Legion Magazine, Band 106, S. 20
Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent
Visceral hypersensitivity (VH) is a hallmark of many functional gastrointestinal disorders including irritable bowel syndrome and is categorized by a dull, diffuse sensation of abdominal pain. Recently, the gut microbiota has been implicated in VH in male mice, but the effects in females have yet to be explored fully. To this end, we now show that somewhat surprisingly, female germ-free mice have similar visceral pain responses to colorectal distension (CRD) as their conventional controls. However, we show that although sensitivity to CRD is estrous cycle stage-dependent in conventional mice, it is not in germ-free mice. Further, ovariectomy (OVX) induced VH in conventional but not germ-free mice, and induced weight gain regardless of microbiota status. Finally, we show that estrogen-replacement ameliorated OVX-induced VH. Taken together, this study provides evidence for a major role of female sex hormones and the gut microbiota in sensation of visceral pain in females. ; Funding: This work was funded by Science Foundation Ireland through the Irish Government's National Development Plan in the form of a center grant (APC Microbiome Institute Grant Number SFI/12/RC/2273_P2).
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In: American Indian Culture and Research Journal, Band 18, Heft 2, S. 207-266