Suchergebnisse

Proceedings for the 1998 Command and Control Research and Technology Symposium Command and Control for the Next Millenium June 29-July1, 1998 Naval Postgraduate School Monterey, California Track 5 Organization and Doctrine Development ; Humanitarian Assistance and Disaster Relief (HA/DR) operations are the most frequent of current operations. At last year's symposium one of the authors presented a paper outlining a six-step program for translating JV2010 capabilities into new concepts for military support to HA/DR operations. This paper covers the completed activities: an HA/DR test involving the USCINCPAC's Political Military Anchor Desk (PMAD), the Workshop on HA/DR in the Next Century and the Virtual Information Center (VIC) experiment in conjunction with the Center of Excellence in Disaster Management and Humanitarian Assistance (COE).

<b><i>Purpose:</i></b> We have identified 27 families in Newfoundland and Labrador (NL) with the founder variant <i>TMEM43</i> p.S358L responsible for 1 form of arrhythmogenic right ventricular cardiomyopathy. Current screening guidelines rely solely on cascade genetic screening, which may result in unrecognized, high-risk carriers who would benefit from preemptive implantable cardioverter-defibrillator therapy. This pilot study explored the acceptability among subjects to <i>TMEM43</i> p.S358L population-based genetic screening (PBGS) in this Canadian province. <b><i>Methods:</i></b> A prospective cohort study assessed attitudes, psychological distress, and health-related quality of life (QOL) in unselected individuals who underwent genetic screening for the <i>TMEM43</i> p.S358L variant. Participants (<i>n</i> = 73) were recruited via advertisements and completed 2 surveys at baseline, 6 months, and 1 year which measured health-related QOL (SF-36v2) and psychological distress (Impact of Events Scale). <b><i>Results:</i></b> No variant-positive carriers were identified. Of those screened through a telephone questionnaire, &#x3e;95% felt positive about population-genetic screening for <i>TMEM43</i> p.S358L, though 68% reported some degree of anxiety after seeing the advertisement. There were no significant changes in health-related QOL or psychological distress scores over the study period. <b><i>Conclusion:</i></b> Despite some initial anxiety, we show support for PBGS among research subjects who screened negative for the <i>TMEM43</i> p.S358L variant in NL. These findings have implications for future PBGS programs in the province.