Suchergebnisse

The present research aims to explore the role of knowledge creation and absorptive capacity as mediating variables between knowledge acquisition, knowledge sharing, and companies' organizational innovation. A theoretical model supporting the hypothesized relationships is developed, and then research hypotheses are tested with a sample of 111 industrial organizations, using partial least squares structural equation modeling. The results show that knowledge creation positively influences innovation and partially mediates the relationship between intra‐firm knowledge sharing and innovation. Knowledge acquisition from external partners is not enough to promote innovation results but significantly reinforces absorptive capacity as well as knowledge sharing. Companies' absorptive capacity fosters the creation of knowledge, but does not significantly influence organizational innovation. The small sample size limits generalization of the present findings. Further research should explore the complementary role of knowledge creation and absorptive capacity in both small and medium‐sized enterprises and large companies. Knowledge management practitioners should facilitate a knowledge sharing environment, where new ideas and solutions can be developed, and consequently innovation outcomes are likely to occur. This paper follows recent approaches to mediation analysis and covers advanced topics in partial least squares structural equation modeling literature, providing empirical examples of the application of hierarchical component models and mediation analysis using bootstrap. Copyright © 2016 John Wiley & Sons, Ltd.

This is a comparative study between the ideas of the philosopher Paul Ricoeur (1913-2005) and the novelist Milan Kundera (1929-) about the experiences of time and memory. It starts with an comparison of the ideas of both thinkers on selfness, history and the experience of time. In a second moment, the thoughts of both are placed in a critical confrontation, especially with regard to their respective understandings of the nature of the human experience of time and the limits of memory. Next, Kundera's ideas and hypotheses are examined in the light of Ricoeur's hermeneutics, with the intention of showing that this is where this hermeneutics is most intensely challenged, which best shows its philosophical valences. Finally, it is intended to show that this confrontation results in interesting convergences through which both thinkers offer similar and complementary perspectives for the purpose of cultivating a happy memory and a living experience of time.

This article aims to present the relevance of the narrative resource in the representation and in the constitution of the selfness. To achieve this goal, a comparative strategy was chosen between an anti-narrative and narrative positions with regard to the powers of narration in apprehending and composing the domain of identifications. In a first moment, a reconstruction of Jean-Paul Sartre's positions on narration will be carried out, based on the phenomenological ontology of Being and nothingness, as well as the considerations about narrative and identity found in the novel Nausea and in the text of War diaries: notebooks from a phony war. The next moment will explore narrative arguments in Alasdair MacIntyre's After virtue, Charles Taylor's The sources of the self, and especially Paul Ricoeur's in Time and narrative and Self as another. Finally, in the most strictly comparative moment, it is intended to show certain difficulties of the anti-narrative position, as well as the fruitfulness of the narrative position, with regard to the different way of managing the demand for meaning in the anti-narrative rejection of identity and the acceptance of the challenge of permanent elaboration of the meaning of the narrative position.

Several prominent public health hazards [29] that occurred at the beginning of this century due to adverse drug events (ADEs) have raised international awareness of governments and industries about pharmacovigilance (PhV) [6,7], the science and activities to monitor and prevent adverse events caused by pharmaceutical products after they are introduced to the market. A major data source for PhV is large-scale longitudinal observational databases (LODs) [6] such as electronic health records (EHRs) and medical insurance claim databases. Inspired by the Self-Controlled Case Series (SCCS) model [27], arguably the leading method for ADE discovery from LODs, we propose baseline regularization, a regularized generalized linear model that leverages the diverse health profiles available in LODs across different individuals at different times. We apply the proposed method as well as SCCS to the Marshfield Clinic EHR. Experimental results suggest that the proposed method outperforms SCCS under various settings in identifying benchmark ADEs from the Observational Medical Outcomes Partnership ground truth [26].

This paper presents findings from semi-structured interviews with 17 practitioners representing 14 exit interventions in 7 European countries. Drawing from the literature, the study identified analytical dimensions that provided the semi-structured interview script's analytical framework (e.g., programme characteristics, implementation team, type of intervention, contact approach, programmes' duration, the use of risk and needs assessment tools, follow-up/monitoring strategies/aftercare procedures). Results suggest that the goals, role of ideology and contact approach differ considerably across exit programmes. The use of risk and needs assessment tools is inconsistent across the programmes. The programmes' evaluation was unstructured and primarily qualitative. The study has practical implications, namely the significant effort required to train exit practitioners in risk and needs assessment tools. A multi-agency approach will help improve the follow-up and aftercare practices. Acknowledgment This research was partially funded by the European Union Internal Security Fund (ISF) – Police, Grant Agreement: 823690 — Integrated Exit Programme for Prison and Probation (WayOut)

Iron acquisition systems have to be tightly regulated to assure a continuous supply of iron, since it is essential for survival, but simultaneously to prevent iron overload that is toxic to the cells. In budding yeast, the low‑iron sensing transcription factor Aft1p is a master regulator of the iron regulon. Our previous work revealed that bioactive sphingolipids modulate iron homeostasis as yeast cells lacking the sphingomyelinase Isc1p exhibit an upregulation of the iron regulon. In this study, we show that Isc1p impacts on iron accumulation and localization. Notably, Aft1p is activated in isc1Δ cells due to a decrease in its phosphorylation and an increase in its nuclear levels. Consistently, the expression of a phosphomimetic version of Aft1p-S210/S224 that favours its nuclear export abolished iron accumulation in isc1Δ cells. Notably, the Hog1p kinase, homologue of mammalian p38, interacts with and directly phosphorylates Aft1p at residues S210 and S224. However, Hog1p-Aft1p interaction decreases in isc1Δ cells, which likely contributes to Aft1p dephosphorylation and consequently to Aft1p activation and iron overload in isc1Δ cells. These results suggest that alterations in sphingolipid composition in isc1Δ cells may impact on iron homeostasis by disturbing the regulation of Aft1p by Hog1p. To our knowledge, Hog1p is the first kinase reported to directly regulate Aft1p, impacting on iron homeostasis. ; This article is a result of the project Norte-01-0145-FEDER-000008 - Porto Neurosciences and Neurologic Disease Research Initiative at I3S supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). CP was supported by Fundo Social Europeu and Programa Operacional Potencial Humano through FCT investigator grant IF/00889/2015. FP and EdN lab is supported by grants from the Spanish Ministry of Economy and Competitiveness (BFU2015-64437-P and FEDER to FP; BFU2014-52333-P and FEDER to EN), the Catalan Government (2014 SGR 599 to FP and EN) and by Fundación Botín, by Banco Santander through its Santander Universities Global Division to FP. FP is recipient of an ICREA Acadèmia (Generalitat de Catalunya).