Suchergebnisse

[EN] A new colorimetric system for NO(g) detection is described. The detection method is based on the aggregation of modified AuNPs through a Cu(I) catalyzed click reaction promoted by the in situ reduction of Cu(II) by NO ; We acknowledge the Spanish Government (MAT2009-14564-C04-03 and MAT2012-38429-C04-02) for financial support. A. M. is grateful to the Spanish Government for a fellowship. SCSIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. ; Marti, A.; Costero Nieto, AM.; Gaviña Costero, P.; Parra Álvarez, M. (2015). Selective colorimetric NO(g) detection based on the use of modified gold nanoparticles using click chemistry. Chemical Communications. 51(15):3077-3079. https://doi.org/10.1039/c4cc10149a ; S ; 3077 ; 3079 ; 51 ; 15 ; Nagano, T. (1999). Practical methods for detection of nitric oxide. Luminescence, 14(6), 283-290. doi:10.1002/(sici)1522-7243(199911/12)14:6 283::aid-bio572>3.0.co;2-g ; L. J. Ignarro , Nitric Oxide: Biology and Pathobiology, Academic Press, San Diego, 2010 ; Ma, S., Fang, D.-C., Ning, B., Li, M., He, L., & Gong, B. (2014). The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide. Chem. Commun., 50(49), 6475-6478. doi:10.1039/c4cc01142b ; Kojima, H., Nakatsubo, N., Kikuchi, K., Kawahara, S., Kirino, Y., Nagoshi, H., … Nagano, T. (1998). Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators: Diaminofluoresceins. Analytical Chemistry, 70(13), 2446-2453. doi:10.1021/ac9801723 ; Chen, X., Tian, X., Shin, I., & Yoon, J. (2011). Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species. Chemical Society Reviews, 40(9), 4783. doi:10.1039/c1cs15037e ; Beltrán, A., Isabel Burguete, M., Abánades, D. R., Pérez-Sala, D., Luis, S. V., & Galindo, F. (2014). Turn-on fluorescent probes for nitric oxide sensing based on the ortho-hydroxyamino structure showing no interference with dehydroascorbic acid. Chemical Communications, 50(27), 3579. ...

3077 3079 51 15 ; S ; [EN] A new colorimetric system for NO(g) detection is described. The detection method is based on the aggregation of modified AuNPs through a Cu(I) catalyzed click reaction promoted by the in situ reduction of Cu(II) by NO We acknowledge the Spanish Government (MAT2009-14564-C04-03 and MAT2012-38429-C04-02) for financial support. A. M. is grateful to the Spanish Government for a fellowship. SCSIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. Marti, A.; Costero Nieto, AM.; Gaviña Costero, P.; Parra Álvarez, M. (2015). Selective colorimetric NO(g) detection based on the use of modified gold nanoparticles using click chemistry. Chemical Communications. 51(15):3077-3079. https://doi.org/10.1039/c4cc10149a Nagano, T. (1999). Practical methods for detection of nitric oxide. Luminescence, 14(6), 283-290. doi:10.1002/(sici)1522-7243(199911/12)14:63.0.co;2-g L. J. Ignarro , Nitric Oxide: Biology and Pathobiology, Academic Press, San Diego, 2010 Ma, S., Fang, D.-C., Ning, B., Li, M., He, L., & Gong, B. (2014). The rational design of a highly sensitive and selective fluorogenic probe for detecting nitric oxide. Chem. Commun., 50(49), 6475-6478. doi:10.1039/c4cc01142b Kojima, H., Nakatsubo, N., Kikuchi, K., Kawahara, S., Kirino, Y., Nagoshi, H., … Nagano, T. (1998). Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators: Diaminofluoresceins. Analytical Chemistry, 70(13), 2446-2453. doi:10.1021/ac9801723 Chen, X., Tian, X., Shin, I., & Yoon, J. (2011). Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species. Chemical Society Reviews, 40(9), 4783. doi:10.1039/c1cs15037e Beltrán, A., Isabel Burguete, M., Abánades, D. R., Pérez-Sala, D., Luis, S. V., & Galindo, F. (2014). Turn-on fluorescent probes for nitric oxide sensing based on the ortho-hydroxyamino structure showing no interference with dehydroascorbic acid. Chemical Communications, 50(27), 3579. doi:10.1039/c3cc49555h Lv, X., ...

Two new Eu3+ and Au3+ BODIPY-complexes capable of chromofluorogenically detecting micromolar concentrations of V-type nerve agent surrogates by a simple displacement assay are described ; Financial support from the Spanish Government (Project MAT2012-38429-C04) and the Generalitat Valencia (Project PROMETEOII/2014/047) is gratefully acknowledged. A.B.B acknowledges the award of a pre-doctoral FPI fellowship. SCIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. ; Barba Bon, A.; Costero Nieto, AM.; Gil Grau, S.; Sancenón Galarza, F.; Martínez Mañez, R. (2014). Chromo-fluorogenic BODIPY-complexes for selective detection of V-type nerve agent surrogates. Chemical Communications. 50(87):13289-13291. https://doi.org/10.1039/c4cc05945j ; S ; 13289 ; 13291 ; 50 ; 87 ; Kim, K., Tsay, O. G., Atwood, D. A., & Churchill, D. G. (2011). Destruction and Detection of Chemical Warfare Agents. Chemical Reviews, 111(9), 5345-5403. doi:10.1021/cr100193y ; S. M. Somani , Chemical Warfare Agent, Academic Press, San Diego, 1992 ; P. Taylor , in The Pharmacological Basis of Therapeutics, ed. J. G. Hardman, L. E. Limbird and A. G. Gilman, McGraw-Hill, New York, 10th edn, 2001, pp. 175–191 ; J. A. Vale , P.Rice and T. C.Marrs, in Chemical Warfare Agents: Toxicology and Treatment, ed. T. C. Marrs, R. L. Maynard and F. R. Sidell, John Wiley & Sons, Chichester, 2007 ; R. Gupta , Handbook of Toxicology of Chemical Warfare Agents, Academic Press, London, 2009 ; Wang, H., Wang, J., Choi, D., Tang, Z., Wu, H., & Lin, Y. (2009). EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. Biosensors and Bioelectronics, 24(8), 2377-2383. doi:10.1016/j.bios.2008.12.013 ; Steiner, W. E., Klopsch, S. J., English, W. A., Clowers, B. H., & Hill, H. H. (2005). Detection of a Chemical Warfare Agent Simulant in Various Aerosol Matrixes by Ion Mobility Time-of-Flight Mass Spectrometry. ...

13289 13291 50 87 ; S ; Two new Eu3+ and Au3+ BODIPY-complexes capable of chromofluorogenically detecting micromolar concentrations of V-type nerve agent surrogates by a simple displacement assay are described Financial support from the Spanish Government (Project MAT2012-38429-C04) and the Generalitat Valencia (Project PROMETEOII/2014/047) is gratefully acknowledged. A.B.B acknowledges the award of a pre-doctoral FPI fellowship. SCIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. Barba Bon, A.; Costero Nieto, AM.; Gil Grau, S.; Sancenón Galarza, F.; Martínez Mañez, R. (2014). Chromo-fluorogenic BODIPY-complexes for selective detection of V-type nerve agent surrogates. Chemical Communications. 50(87):13289-13291. doi:10.1039/c4cc05945j Kim, K., Tsay, O. G., Atwood, D. A., & Churchill, D. G. (2011). Destruction and Detection of Chemical Warfare Agents. Chemical Reviews, 111(9), 5345-5403. doi:10.1021/cr100193y S. M. Somani , Chemical Warfare Agent, Academic Press, San Diego, 1992 P. Taylor , in The Pharmacological Basis of Therapeutics, ed. J. G. Hardman, L. E. Limbird and A. G. Gilman, McGraw-Hill, New York, 10th edn, 2001, pp. 175–191 J. A. Vale , P.Rice and T. C.Marrs, in Chemical Warfare Agents: Toxicology and Treatment, ed. T. C. Marrs, R. L. Maynard and F. R. Sidell, John Wiley & Sons, Chichester, 2007 R. Gupta , Handbook of Toxicology of Chemical Warfare Agents, Academic Press, London, 2009 Wang, H., Wang, J., Choi, D., Tang, Z., Wu, H., & Lin, Y. (2009). EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. Biosensors and Bioelectronics, 24(8), 2377-2383. doi:10.1016/j.bios.2008.12.013 Steiner, W. E., Klopsch, S. J., English, W. A., Clowers, B. H., & Hill, H. H. (2005). Detection of a Chemical Warfare Agent Simulant in Various Aerosol Matrixes by Ion Mobility Time-of-Flight Mass Spectrometry. Analytical Chemistry, 77(15), ...

Test strips that in combination with a portable fluorescence reader or digital camera can rapidly and selectively detect chemical warfare agents (CWAs) such as Tabun (GA), Sarin (GB), and Soman (GD) and their simulants in the gas phase have been developed. The strips contain spots of a hybrid indicator material consisting of a fluorescent BODIPY indicator covalently anchored into the channels of mesoporous SBA silica microparticles. The fluorescence quenching response allows the sensitive detection of CWAs in the mu g m(-3) range in a few seconds. ; Financial support from the Alexander von Humboldt Foundation, the German Federal Ministry for Economic Affairs and Energy, European FEDER funds (MAT2012-38429-C04), the Generalitat Valenciana (PROMETEOII/2014/047), and the Spanish Government is gratefully acknowledged. We thank S. Selve (Technical University Berlin) for TEM images, A. Zehl (Humboldt University Berlin) for elemental analysis, D. Pfeifer (BAM, Div. 1.3) for NMR, A. Zimathies (BAM 1.3) for N INF>2 /INF> adsorption/desorption, S. Ewald and A. Lehmann (BAM 1.5 & 1.8) for MS support, and T. Fischer (BAM 1.9) for support with the fluorescence decay measurements. ; Climent Terol, E.; Biyikal, M.; Gawlitza, K.; Dropa, T.; Urban, M.; Costero Nieto, AM.; Martínez-Máñez, R. (2016). A Rapid and Sensitive Strip-Based Quick Test for Nerve Agents Tabun, Sarin, and Soman Using BODIPY-Modified Silica Materials. Chemistry - A European Journal. 22(32):11138-11142. https://doi.org/10.1002/chem.201601269 ; S ; 11138 ; 11142 ; 22 ; 32

Two new aryl carbinols (1 and 3) have been synthesised and characterised and their ability as OFF-ON probes for the chromogenic detection of the nerve agent simulant in acetonitrile has been tested. In addition compound 2 has been also studied. The carbinols suffered a phosphorylation reaction followed by an elimination process giving rise to the corresponding carbocations. This transformation of the carbinol into the carbocation is responsible for a significant color change. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012. ; Financial support from the Spanish Government (project MAT2009-14564-C04-01) and the Generalitat Valencia (project PROMETEO/2009/016) is gratefully acknowledged. R. G. is grateful to the Spanish Ministry of Education and S. R. to Generalitat Valencia for their grants. ; Royo Calvo, S.; Gotor Candel, RJ.; Costero Nieto, AM.; Parra Álvarez, M.; Gil Grau, S.; Martínez Mañez, R.; Sancenón Galarza, F. (2012). Aryl carbinols as nerve agent probes. Influence of the conjugation on the sensing properties. New Journal of Chemistry. 36(12):1485-1489. https://doi.org/10.1039/c2nj40104e ; S ; 1485 ; 1489 ; 36 ; 12 ; Sadik, O. A., Land, W. H., & Wang, J. (2003). Targeting Chemical and Biological Warfare Agents at the Molecular Level. Electroanalysis, 15(14), 1149-1159. doi:10.1002/elan.200390140 ; Russell, A. J., Berberich, J. A., Drevon, G. F., & Koepsel, R. R. (2003). Biomaterials for Mediation of Chemical and Biological Warfare Agents. Annual Review of Biomedical Engineering, 5(1), 1-27. doi:10.1146/annurev.bioeng.5.121202.125602 ; Wang, H., Wang, J., Choi, D., Tang, Z., Wu, H., & Lin, Y. (2009). EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. Biosensors and Bioelectronics, 24(8), 2377-2383. doi:10.1016/j.bios.2008.12.013 ; Im, H.-J., & Song, K. (2009). Applications of Prompt Gamma Ray Neutron Activation Analysis: ...

Two triaryl methane cations have been used as probes for colorimetric detection of nerve agent simulants. Buffered mixed aqueous solutions of 1 and 2 showed bathochromic shifts in the presence of DCNP (diethylcyanophosphonate) and DCP (diethylchlorophosphate). The colour modulation can be observed to the naked eye. Appropriate mechanisms for the recognition event are proposed. © 2012 Elsevier Ltd. ; We thank the Spanish Government (projects MAT2009-14564-C01 and MAT2009-14564-C03) and the Generalitat Valenciana (project PROMETEO/2009/016) for support. R.G. is grateful to the Spanish Government for a fellowship. S.R. is grateful to the Generalitat Valenciana for a fellowship. SCSIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. ; Gotor Candel, RJ.; Royo Calvo, S.; Costero Nieto, AM.; Parra Álvarez, M.; Gil Grau, S.; Martínez Mañez, R.; Sancenón Galarza, F. (2012). Nerve agent simulant detection by using chromogenic triaryl methane cation probes. Tetrahedron. 68(41):8612-8616. https://doi.org/10.1016/j.tet.2012.07.091 ; S ; 8612 ; 8616 ; 68 ; 41

1485 1489 36 12 ; S ; Two new aryl carbinols (1 and 3) have been synthesised and characterised and their ability as OFF-ON probes for the chromogenic detection of the nerve agent simulant in acetonitrile has been tested. In addition compound 2 has been also studied. The carbinols suffered a phosphorylation reaction followed by an elimination process giving rise to the corresponding carbocations. This transformation of the carbinol into the carbocation is responsible for a significant color change. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012. Financial support from the Spanish Government (project MAT2009-14564-C04-01) and the Generalitat Valencia (project PROMETEO/2009/016) is gratefully acknowledged. R. G. is grateful to the Spanish Ministry of Education and S. R. to Generalitat Valencia for their grants. Royo Calvo, S.; Gotor Candel, RJ.; Costero Nieto, AM.; Parra Álvarez, M.; Gil Grau, S.; Martínez Mañez, R.; Sancenón Galarza, F. (2012). Aryl carbinols as nerve agent probes. Influence of the conjugation on the sensing properties. New Journal of Chemistry. 36(12):1485-1489. https://doi.org/10.1039/c2nj40104e Sadik, O. A., Land, W. H., & Wang, J. (2003). Targeting Chemical and Biological Warfare Agents at the Molecular Level. Electroanalysis, 15(14), 1149-1159. doi:10.1002/elan.200390140 Russell, A. J., Berberich, J. A., Drevon, G. F., & Koepsel, R. R. (2003). Biomaterials for Mediation of Chemical and Biological Warfare Agents. Annual Review of Biomedical Engineering, 5(1), 1-27. doi:10.1146/annurev.bioeng.5.121202.125602 Wang, H., Wang, J., Choi, D., Tang, Z., Wu, H., & Lin, Y. (2009). EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. Biosensors and Bioelectronics, 24(8), 2377-2383. doi:10.1016/j.bios.2008.12.013 Im, H.-J., & Song, K. (2009). Applications of Prompt Gamma Ray Neutron Activation Analysis: Detection of Illicit ...

[EN] This critical review is focused on examples reported from 1947 to 2010 related to the design of chromo-fluorogenic chemosensors and reagents for explosives (141 references). © 2012 The Royal Society of Chemistry. ; Financial support from the Spanish Government (project MAT2009-14564-C04) and the Generalitat Valencia (project PROMETEO/2009/016) is gratefully acknowledged. Y.S. is grateful to the Spanish Ministry of Science and Innovation for her grant. ; Salinas Soler, Y.; Martínez Mañez, R.; Marcos Martínez, MD.; Sancenón Galarza, F.; Costero Nieto, AM.; Parra Álvarez, M.; Gil Grau, S. (2012). Optical chemosensors and reagents to detect explosives. Chemical Society Reviews. 41(3):1261-1296. https://doi.org/10.1039/c1cs15173h ; S ; 1261 ; 1296 ; 41 ; 3 ; Furton, K. (2001). The scientific foundation and efficacy of the use of canines as chemical detectors for explosives. Talanta, 54(3), 487-500. doi:10.1016/s0039-9140(00)00546-4 ; H�kansson, K., Coorey, R. V., Zubarev, R. A., Talrose, V. L., & H�kansson, P. (2000). Low-mass ions observed in plasma desorption mass spectrometry of high explosives. Journal of Mass Spectrometry, 35(3), 337-346. doi:10.1002/(sici)1096-9888(200003)35:3 337::aid-jms940>3.0.co;2-7 ; Walsh, M. (2001). Determination of nitroaromatic, nitramine, and nitrate ester explosives in soil by gas chromatography and an electron capture detector. Talanta, 54(3), 427-438. doi:10.1016/s0039-9140(00)00541-5 ; Sylvia, J. M., Janni, J. A., Klein, J. D., & Spencer, K. M. (2000). Surface-Enhanced Raman Detection of 2,4-Dinitrotoluene Impurity Vapor as a Marker To Locate Landmines. Analytical Chemistry, 72(23), 5834-5840. doi:10.1021/ac0006573 ; Yinon, J. (1982). Mass spectrometry of explosives: Nitro compounds, nitrate esters, and nitramines. Mass Spectrometry Reviews, 1(3), 257-307. doi:10.1002/mas.1280010304 ; Mathurin, J. C., Faye, T., Brunot, A., Tabet, J. C., Wells, G., & Fuché, C. (2000). High-Pressure Ion Source Combined with an In-Axis Ion Trap Mass Spectrometer. 1. ...

The synthesis, characterization and sensing features of a novel probe 1 for the selective chromogenic recognition of diisopropylfluorophosphate (DFP), a sarin and soman mimic, in 99:1 (v/ v) water/acetonitrile and in the gas phase is reported. Colour modulation is based on the combined reaction of phosphorylation of 1 and fluoride-induced hydrolysis of a silyl ether moiety. As fluoride is a specific reaction product of the reaction between DFP and the OH group, the probe shows a selective colour modulation in the presence of this chemical. Other nerve agent simulants, certain anions, oxidant species and other organophosphorous compounds were unable to induce colour changes in 1. This is one of the very few examples of a selective detection, in solution and in the gas phase, of a sarin and soman simulant versus other reactive derivatives such as the tabun mimic diethylcyanophosphate (DCNP). ; Financial support from the Spanish Government (Project MAT2012-38429-C04) is gratefully acknowledged. S. E. is grateful to the Generalitat Valenciana for his Santiago Grisolia fellowship. L. P. thanks the Universitat Politecnica de Valencia for his doctoral fellowship. ; El Sayed Shehata Nasr, S.; Pascual Vidal, L.; Agostini, A.; Martínez-Máñez, R.; Sancenón Galarza, F.; Costero Nieto, AM.; Parra Álvarez, M. (2014). A Chromogenic Probe for the Selective Recognition of Sarin and Soman Mimic DFP. ChemistryOpen. 3(4):142-145. https://doi.org/10.1002/open.201402014 ; S ; 142 ; 145 ; 3 ; 4

[EN] Silica mesoporous microparticles loaded with both rhodamine B fluorophore (S1) or hydrocortisone (S2), and capped with an olsalazine derivative, are prepared and fully characterized. Suspensions of Si and S2 in water at an acidic and a neutral pH show negligible dye/drug release, yet a notable delivery took place when the reducing agent sodium dithionite is added because of hydrolysis of an azo bond in the capping ensemble. Additionally, olsalazine fragmentation induced 5-aminosalicylic acid (5-ASA) release. In vitro digestion models show that S1 and S2 solids are suitable systems to specifically release a pharmaceutical agent in the colon. In vivo pharmacokinetic studies in rats show a preferential rhodamine B release from Si in the colon. Moreover, a model of ulcerative colitis is induced in rats by oral administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) solutions, which was also used to prove the efficacy of S2 for colitis treatment. The specific delivery of hydrocortisone and 5-ASA from S2 material to the colon tissue in injured rats markedly lowers the colon/body weight ratio and the clinical activity score. Histological studies showed a remarkable reduction in inflammation, as well as an intensive regeneration of the affected tissues. ; We thank the Generalitat Valenciana (Project PROMETE02018/024) and the Spanish Government (Projects AGL2015-70235-C2-2-R and MAT2015-64139-C4-1-R (MINECO/FEDER)) for support. A.H.T. thanks the Spanish MEC for his FPU fellowship. The authors also thank the support of the Electron Microscopy Service at the UPV. The SCSIE (of the Universitat de Valencia) is also gratefully acknowledged for all the equipment used. NMR spectra were measured at the U26 facility of ICTS "NANBIOSIS" at the Universitat de Valencia. ; Hernández Teruel, A.; Pérez-Esteve, É.; González-Álvarez, I.; González-Álvarez, M.; Costero Nieto, AM.; Ferri, D.; Gaviña, P. (2019). Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel ...

2418 2429 16 6 ; S ; [EN] Silica mesoporous microparticles loaded with both rhodamine B fluorophore (S1) or hydrocortisone (S2), and capped with an olsalazine derivative, are prepared and fully characterized. Suspensions of Si and S2 in water at an acidic and a neutral pH show negligible dye/drug release, yet a notable delivery took place when the reducing agent sodium dithionite is added because of hydrolysis of an azo bond in the capping ensemble. Additionally, olsalazine fragmentation induced 5-aminosalicylic acid (5-ASA) release. In vitro digestion models show that S1 and S2 solids are suitable systems to specifically release a pharmaceutical agent in the colon. In vivo pharmacokinetic studies in rats show a preferential rhodamine B release from Si in the colon. Moreover, a model of ulcerative colitis is induced in rats by oral administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) solutions, which was also used to prove the efficacy of S2 for colitis treatment. The specific delivery of hydrocortisone and 5-ASA from S2 material to the colon tissue in injured rats markedly lowers the colon/body weight ratio and the clinical activity score. Histological studies showed a remarkable reduction in inflammation, as well as an intensive regeneration of the affected tissues. We thank the Generalitat Valenciana (Project PROMETE02018/024) and the Spanish Government (Projects AGL2015-70235-C2-2-R and MAT2015-64139-C4-1-R (MINECO/FEDER)) for support. A.H.T. thanks the Spanish MEC for his FPU fellowship. The authors also thank the support of the Electron Microscopy Service at the UPV. The SCSIE (of the Universitat de Valencia) is also gratefully acknowledged for all the equipment used. NMR spectra were measured at the U26 facility of ICTS "NANBIOSIS" at the Universitat de Valencia. Hernández Teruel, A.; Pérez-Esteve, É.; González-Álvarez, I.; González-Álvarez, M.; Costero Nieto, AM.; Ferri, D.; Gaviña, P. (2019). Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of ...

[EN] Three fluorescent probes (1–3) for the selective and sensitive detection of hydrogen sulfide have been synthesized and characterized. Probe 1 is a coumarin derivative functionalized with an azide moiety whereas 2 contain the azide reactive group into a naphthalene fluorophore backbone. Probe 3 is composed also by a naphthalene fluorophore but, in this case, functionalized with a sulfonylazide reactive moiety. Probes 1 and 3 are non-fluorescent whereas 2 is weakly emissive in HEPES (10 mM, pH 7.4)–DMSO 99:1 (v/v). The emission behavior of the three probes was tested against selected anions, bio-thiols and oxidant molecules. Of all the chemical species tested, only HS− is able to induce an enhancement in the emission intensity (50, 11 and 20-fold for 1, 2 and 3, respectively). The observed emission in the presence of hydrogen sulfide is ascribed, in the case of probes 1 and 2, to an azide–amine reduction induced by HS− anion, whereas for probe 3 the sensing mechanism is related with a sulfonylazide–sulfonamide conversion. The three probes are very sensitive to HS− anion with limits of detection of 0.17, 0.20 and 0.40 mM for 1, 2 and 3 respectively. Cell viability studies demonstrated that 1–3 probes are essentially non-toxic at concentrations 10–50 μM and are well suited for in vivo studies. Finally, probe 1 was used for the detection on intracellular HS− anion in HeLa cells by means of confocal microscopy. ; Financial support from the Spanish Government (Project MAT2012-38429-004-01) and the Generalitat Valenciana (Project PROMETEO/2009/016) is gratefully acknowledged. S.E. is grateful to the Generalitat Valenciana for his Santiago Grisolia fellow. C.T. also thanks the Ministerio de Ciencia e Innovacion for her FPU grant. L.E.S.F. thanks the Carolina Foundation and UPNFM-Honduras for his doctoral grant. ; El Sayed Shehata Nasr, S.; De La Torre Paredes, C.; Santos Figueroa, LE.; Marín Hernández, C.; Martínez Mañez, R.; Sancenón Galarza, F.; Costero Nieto, AM. (2015). Azide and sulfonylazide functionalized ...

[EN] A hybrid capped mesoporous material, which was selectively opened in the presence of Tetryl and TNT, has been synthesised and used for the fluorogenic recognition of these nitroaromatic explosives. ; Financial support from the Spanish Government (project MAT2012-38429-C04-01) and the Generalitat Valencia (project PROMETEO/2009/016) is gratefully acknowledged. Y.S. and E.P. are grateful to the Spanish Ministry of Science and Innovation for their grants. A. A. also thanks the Generalitat Valenciana for his Santiago Grisolia fellowship. ; Salinas Soler, Y.; Agostini, A.; Pérez Esteve, E.; Martínez Mañez, R.; Sancenón Galarza, F.; Marcos Martínez, MD.; Soto Camino, J. (2013). Fluorogenic detection of Tetryl and TNT explosives using nanoscopic-capped mesoporous hybrid materials. Journal of Materials Chemistry. 1(11):3561-3564. https://doi.org/10.1039/C3TA01438J ; S ; 3561 ; 3564 ; 1 ; 11 ; Singh, S. (2007). Sensors—An effective approach for the detection of explosives. Journal of Hazardous Materials, 144(1-2), 15-28. doi:10.1016/j.jhazmat.2007.02.018 ; Schulte-Ladbeck, R., Vogel, M., & Karst, U. (2006). Recent methods for the determination of peroxide-based explosives. Analytical and Bioanalytical Chemistry, 386(3), 559-565. doi:10.1007/s00216-006-0579-y ; Smith, R. G., D'Souza, N., & Nicklin, S. (2008). A review of biosensors and biologically-inspired systems for explosives detection. The Analyst, 133(5), 571. doi:10.1039/b717933m ; Moore, D. S. (2004). Instrumentation for trace detection of high explosives. Review of Scientific Instruments, 75(8), 2499-2512. doi:10.1063/1.1771493 ; H�kansson, K., Coorey, R. V., Zubarev, R. A., Talrose, V. L., & H�kansson, P. (2000). Low-mass ions observed in plasma desorption mass spectrometry of high explosives. Journal of Mass Spectrometry, 35(3), 337-346. doi:10.1002/(sici)1096-9888(200003)35:3 337::aid-jms940>3.0.co;2-7 ; Wallis, E., Griffin, T. M., Popkie, Jr., N., Eagan, M. A., McAtee, R. F., Vrazel, D., & McKinly, J. (2005). Instrument response ...

MCM-41 silica nanoparticles were used as inorganic scaffolding to prepare a nanoscopic-capped hybrid material S1, which was able to release an entrapped cargo in the presence of certain enzymes, whereas in the absence of enzymes, a zero release system was obtained. S1 was prepared by loading nanoparticles with Safranine O dye and was then capped with a gluconamide derivative. In the absence of enzymes, the release of the dye from the aqueous suspensions of S1 was inhibited as a result of the steric hindrance imposed by the bulky gluconamide derivative, the polymerized gluconamide layer and the formation of a dense hydrogen-bonded network around the pore outlets. Upon the addition of amidase and pronase enzymes, delivery of Safranine O dye was observed due to the enzymatic hydrolysis of the amide bond in the anchored gluconamide derivative. S1 nanoparticles were not toxic for cells, as demonstrated by cell viability assays using HeLa and MCF-7 cell lines, and were associated with lysosomes, as shown by confocal microscopy. Finally, the S1¿CPT material loaded with the cytotoxic drug camptothecin and capped with the gluconamide derivative was prepared. The HeLa cells treated with S1¿CPT underwent cell death as a result of material internalization, and of the subsequent cellular enzyme-mediated hydrolysis and aperture of the molecular gate, which induced the release of the camptothecin cargo. ; We thank the Spanish Government (Project MAT2009-14564-C04 and SAF2010-15512) and the Generalitat Valenciana (Project PROMETEO/2009/016and/2010/005) for support. I. C. thanks the Universitat Politecnica de Valencia for her fellowship. L. M. thanks the Generalitat Valenciana for her post-doctoral VALi+d contract. E. A. and C. T. also thank the CIBER-BBN for contracts. We thank Eva Maria Lafuente Villarreal and Alberto Hernandez Cano from the Confocal Microscopy service of CIPF and the Electronic Microscopy service of UPV for their technical support. ; Candel Busquets, I.; Aznar Gimeno, E.; Mondragón Martínez, L.; De La Torre ...