Suchergebnisse

Selection is a vital part of any immigration programme. However, it must be carried out in the context of the prospective migrant's motivation and attitudes to authority, and the reality situation of a particular country. The procedures adopted by the Australian Department of Immigration in Greece and Yugoslavia are discussed from the perspective of counselling, the provision of information, selection and preventive services. Difficulties faced by the selection officers are examined, but in the author's view considerable improvement is both possible and necessary.

A rapidly growing number of social workers are expressing a deep interest in and strong concern for global situations adversely affecting the well-being of millions of people. Such situations include global poverty, widespread conflict and post-conflict reconstruction, and the large population of displaced persons, and vulnerable and marginalized groups within them. Increasingly practitioners from several professions are actively involved in addressing these issues at local, national and international levels. This book aims to encourage and inform such involvement by drawing together the practice wisdom gradually emerging within the broad scope of international social work practice. Utilizing an integrated perspectives approach incorporating global, human rights, ecological and social development perspectives, the text is designed to prepare social workers, human services professionals, development practitioners and others who ...

Demonstrates that the ideas inherent in social development are practical and not utopian. Discussing and delineating a social development approach, this book argues the need for practicing it at local or grassroots-level communities to promote universal social justice and wellbeing.

It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions. The technical limitations of detecting somatic changes and the lack of insight about the minimum level of erroneous proteins to cause an error catastrophe hampered any firm conclusions on these theories. In this study, we sequenced the whole genome of DNA in whole blood of two pairs of monozygotic (MZ) twins, 40 and 100 years old, by two independent next-generation sequencing (NGS) platforms (Illumina and Complete Genomics). Potentially discordant single-base substitutions supported by both platforms were validated extensively by Sanger, Roche 454, and Ion Torrent sequencing. We demonstrate that the genomes of the two twin pairs are germ-line identical between co-twins, and that the genomes of the 100-year-old MZ twins are discerned by eight confirmed somatic single-base substitutions, five of which are within introns. Putative somatic variation between the 40-year-old twins was not confirmed in the validation phase. We conclude from this systematic effort that by using two independent NGS platforms, somatic single nucleotide substitutions can be detected, and that a century of life did not result in a large number of detectable somatic mutations in blood. The low number of somatic variants observed by using two NGS platforms might provide a framework for detecting disease-related somatic variants in phenotypically discordant MZ twins.