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Modeling the Modification of the Risk of Radon‐Induced Lung Cancer by Environmental Tobacco Smoke
In: Risk analysis: an international journal, Band 12, Heft 4, S. 483-493
ISSN: 1539-6924
The presence of environmental tobacco smoke (ETS)in homes has been implicated in the causation of lung cancer. While of interest in its own right, ETS also influences the risk imposed by radon and its decay products. The interaction between radon progeny and ETS alters the exposure, intake, uptake, biokinetics, dosimetry, and radiobiology of those progeny. The present paper details model predictions of the various influences of ETS on these factors in the U.S. population and provides estimates of the resulting change in the risk from average levels of radon progeny. It is predicted that the presence of ETS produces a very small (perhaps unmeasurable)increase in the risk of radiation‐induced tracheobronchial cancer in homes with initially very high particle concentrations for both active and never‐smokers, but significantly lowers the risk in homes with initially lower particle concentrations for both groups when generation 4 of the lung is considered the target site. For generation 16, the presence of ETS generally increases the radon‐induced risk of lung cancer, although the increase should be unmeasurable at high initial particle concentrations. The net effect of ETS on human health is suggested to be a complicated function of the initial housing conditions, the concentration of particles introduced by smoking, the target generation considered, and the smoking status of exposed populations. This situation precludes any simple statements concerning the role of ETS in governing the incidence of lung cancer in a population.
Cancer Fatalities from Waterborne Radon (Rn‐222)
In: Risk analysis: an international journal, Band 11, Heft 1, S. 135-143
ISSN: 1539-6924
A model of the biokinetics of radon in the human body following ingestion is developed from existing data. Calculations of the probability of cancer fatality from use of radon‐laden water in the home then are presented. The pathways of emanation and ingestion are examined and shown to lead to roughly equal risks. The probability of fatal cancer resulting from lifetime use of water at a radon concentration of 1 pCi/L is shown to be 1 × 10−6, with a reasonable range between 2 × 10−7 and 5 × 10−6. The allowed concentration consistent with an excess risk of 10−4 then is approximately 100 pCi/L, which is exceeded in a significant fraction of U.S. water supplies. The lifetime number of premature deaths due to waterborne radon in the U.S. is estimated to lie between 5000 and 125,000, with a best estimate of 25,000.
Truth and Meaning in the Determination of Radiogenic Risk
In: IRB: ethics & human research, Band 5, Heft 5, S. 1
ISSN: 2326-2222
Decarbonising the world's economy: assessing the feasibility of policies to reduce greenhouse gas emissions
Too often amongst policy makers and thought leaders an assumption is made that we must make a choice between tackling climate change and having a strong economy; tackling climate change and allowing poorer nations to develop; tackling climate change and having a secure energy system. However, a decade of advanced modelling tested against historical data has provided wide evidence that well-chosen policies can be implemented that avoid these apparent either/or choices. This highly interdisciplinary book provides an overview of potential pathways for the decarbonisation of the global economy. By examining the entire global economy, we show policy-makers and thought-leaders that greatly reducing the risks of climate change can be consistent with energy security, economic development in poor nations, and vibrant economies in already developed nations. Advanced models of the relationships between the economy, energy and climate change pioneered at the Cambridge Centre for Climate Change Mitigation Research (4CMR) over the past decade provides a sound evidence base for decisions. This book examines not only the impacts of policies, but also the feasibility of bringing them forward and the ways in which energy, climate and economic policies can and must be joined up if climate, energy and economic goals are to be met globally. Economists, physicists, engineers, policy analysts, environmental scientists, climate scientists, political analysts, lawyers and computational scientists are brought together for the first time to produce analyses that make up a unique approach to a global problem that must be addressed sooner rather than later
Comparing carcinogenicity and acute toxicity for ingestion of the promoting agent okadaic acid
In: Journal of risk research: the official journal of the Society for Risk Analysis Europe and the Society for Risk Analysis Japan, Band 5, Heft 3, S. 195-209
ISSN: 1466-4461