Suchergebnisse

The apparent stalemate in the peace process ordained by the 1998 Good Friday Agreement is related to divisions in Irish sport. Although the accord was approved by 80+% of the people, the process stalled in 1999 because of an inability to resolve the decommissioning of terrorist weapons. The conflict is mirrored in Irish sport, which is mostly split by religious & national affiliation. The Gaelic games of the Gaelic Athletic Assoc are examined as simultaneously being a product of the forces of globalization & a representation of Ireland's county parochialism. How the Gaelic games reflect a meeting of the global & parochial are discussed, along with their relevance to the global-local debates surrounding the stalled peace talks. J. Lindroth

Examines the Gaelic football matches between Meath and Australia in 1967-68. These matches were played in the context of the need for an international platform for games which had only a domestic appeal. Argues that the attempt to internationalise Gaelic games took place in order to promote national prestige and identity in a manner that solely domestic competition could not. Describes and explains the long-term failure of such attempts at internationalism. (Quotes from original text)

This volume sets out to examine the history of Ireland in the years following the Dail's ratification of independence from Britain in 1922. The different authors in the collection, all experts on different aspects of Irish history from the first half of the twentieth century, focus on a wide range of different themes. Considerations of the decline of Redmondite nationalism, the role of Unionism in the Free State, Party structures and organisation, the development of different forms of identity, the nature of economics and the place of the newly independent Ireland within the British Empire are all included. All chapters are either the result of new archival research or else offer a sustained historiographical critique of current thinking.

In conjunction with the second International Environmental Omics Symposium (iEOS) conference, held at the University of Liverpool (United Kingdom) in September 2014, a workshop was held to bring together experts in toxicology and regulatory science from academia, government and industry. The purpose of the workshop was to review the specific roles that high-content omics datasets (eg, transcriptomics, metabolomics, lipidomics, and proteomics) can hold within the adverse outcome pathway (AOP) framework for supporting ecological and human health risk assessments. In light of the growing number of examples of the application of omics data in the context of ecological risk assessment, we considered how omics datasets might continue to support the AOP framework. In particular, the role of omics in identifying potential AOP molecular initiating events and providing supportive evidence of key events at different levels of biological organization and across taxonomic groups was discussed. Areas with potential for short and medium-term breakthroughs were also discussed, such as providing mechanistic evidence to support chemical read-across, providing weight of evidence information for mode of action assignment, understanding biological networks, and developing robust extrapolations of species-sensitivity. Key challenges that need to be addressed were considered, including the need for a cohesive approach towards experimental design, the lack of a mutually agreed framework to quantitatively link genes and pathways to key events, and the need for better interpretation of chemically induced changes at the molecular level. This article was developed to provide an overview of ecological risk assessment process and a perspective on how high content molecular-level datasets can support the future of assessment procedures through the AOP framework.

The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics on the market in Europe after 2013. In that context, the European Commission invited stakeholder bodies (industry, non-governmental organisations, EU Member States, and the Commission's Scientific Committee on Consumer Safety) to identify scientific experts in five toxicological areas, i.e. toxicokinetics, repeated dose toxicity, carcinogenicity, skin sensitisation, and reproductive toxicity for which the Directive foresees that the 2013 deadline could be further extended in case alternative and validated methods would not be available in time. The selected experts were asked to analyse the status and prospects of alternative methods and to provide a scientifically sound estimate of the time necessary to achieve full replacement of animal testing. In summary, the experts confirmed that it will take at least another 7-9 years for the replacement of the current in vivo animal tests used for the safety assessment of cosmetic ingredients for skin sensitisation. However, the experts were also of the opinion that alternative methods may be able to give hazard information, i.e. to differentiate between sensitisers and non-sensitisers, ahead of 2017. This would, however, not provide the complete picture of what is a safe exposure because the relative potency of a sensitiser would not be known. For toxicokinetics, the timeframe was 5-7 years to develop the models still lacking to predict lung absorption and renal/biliary excretion, and even longer to integrate the methods to fully replace the animal toxicokinetic models. For the systemic toxicological endpoints of repeated dose toxicity, carcinogenicity and reproductive toxicity, the time horizon for full replacement could not be estimated.