Suchergebnisse

Acknowledgements The authors thank Paul Manson (HSRU Information Scientist) for help with the database searches, Professor Graeme MacLennan for advice on categorising adaptive design trials, and Professor Marion Campbell for commenting on a draft version of the manuscript. Funding statement RL held an NHS Research Scotland Fellowship during the delivery of this project. The Health Services Research Unit, Institute of Applied Health Sciences (University of Aberdeen), is core-funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. The funders had no involvement in study design, collection, analysis and interpretation of data, reporting or the decision to publish. ; Peer reviewed ; Publisher PDF

Acknowledgements The authors would like to thank the Thomas Walker and Rebecca Albrow (National Institute for Health and Care Excellence) for comments on earlier versions of the model. We also wish to thank the NICE expert committee members who provided information and data to support the development of the model: Dr Andrew Davenport (Royal Free Hospital, London), Dr Simon Roe (Nottingham University Hospitals NHS Trust), Dr Elizabeth Lindley (St James's University Hospital), Dr Wesley Hayes (Great Ormond Street Hospital), Ms Joanne Prince (Central Manchester University Hospitals NHS Foundation Trust), Mr Nick McAleer (Royal Devon & Exeter NHS Foundation Trust), Dr Kay Tyerman (Leeds General Infirmary), Dr Graham Woodrow (St James's University Hospital) and Mr Paul Taylor (lay specialist committee member). Funding This paper presents independent research funded by the National Institute for Health Research (NIHR), commissioned through the NICE Diagnostic Assessment Programme (Project no 15/17/07). The views expressed are those of the authors and not necessarily those of NICE, the NHS, the NIHR or the Department of Health. The Health Economics Research Unit and the Health Services Research Unit, University of Aberdeen, are funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. ; Peer reviewed ; Publisher PDF

We would like to give special thanks to Dr Carrie Stewart for her contribution in manuscript drafting. We gratefully acknowledge Ministry of Science and Technology, the Thai Royal Government Scholarship support towards AN and the study team was also supported by The Dunhill Medical Trust [grant number RPGF1806/66] funds towards PKM and YKL as part of the project entitled "An evidence synthesis suite to inform a future randomised trial of reducing anticholinergic related harm in older adults". The funders had no role in study design or interpretation of the results. ; Peer reviewed ; Postprint

Moira Cruickshank and Rumana Newlands are joint-first authors. Funding Information: Funding This work was supported by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme grant (14/192/71). The work was also supported by an NHS Grampian Endowment grant (16/11/006). KG held a Medical Research Council UK Methodology Fellowship during the delivery of this project (MR/L01193X/1). The Health Services Research Unit, Institute of Applied Health Sciences (University of Aberdeen), is core funded by the chief scientist office of the Scottish Government Health and Social Care Directorates. Disclaimer The funders had no involvement in study design, collection, analysis and interpretation of data, reporting or the decision to publish. ; Peer reviewed ; Publisher PDF

Date of Acceptance: 07/05/15 This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ Acknowledgements The authors would like to thank the investigators who kindly provided additional trials details, the NICE Assessment Subgroup specialist members (Dianna Oxley, Dianne Kitchen, Niall O'Keeffe, Peter Birtles, Peter MacCallum, Rishabh Prasad, and Sue Rhodes) for their assistance with some queries related to the interventions and their use in clinical practice, Charles Boachie for statistical support, and Lara Kemp for secretarial support. Funding This report was commissioned by the NIHR HTA Programme as project number 13/06/2001. The Health Services Research Unit, and Health Economics Research Unit, Institute of Applied Health Sciences, University of Aberdeen, are both core-funded by the Chief Scientist Office of the Scottish Government Health Directorates. The views expressed in this report are those of the authors and not necessarily those of the Chief Scientist Office of the Scottish Government Health Directorates, NIHR HTA Programme or the Department of Health. Any errors are the responsibility of the authors. ; Peer reviewed ; Publisher PDF

Funding National Institute for Health Research Health Technology Assessment Programme. Acknowledgments This work was supported by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme (project no 17/68/01). The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR HTA Programme, or the Department of Health and Social Care, UK. The funders were not actively involved in the research process at any stage. The study design; collection, analysis, and interpretation of data; writing of the manuscript; and decision to submit for publication were performed independent of the funders. The Health Services Research Unit at the University of Aberdeen is funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. The Section of Endocrinology and Investigative Medicine at Imperial College London is funded by grants from the Medical Research Council, Biotechnology and Biological Sciences Research Council, NIHR, an Integrative Mammalian Biology Capacity Building Award, an FP7-HEALTH-2009-241592 EuroCHIP grant, and is supported by the NIHR Biomedical Research Centre Funding Scheme. The following authors are also funded as follows: NIHR Research Professorship (WSD), NIHR post-doctoral fellowship (CNJ). SBhasin receives National Institutes of Health research grant funding. The authors are grateful to Prakash Abraham, Alison Avenell, Craig Ramsay, Graham Scotland, Neil Scott, and Finlay MacKenzie for their advice; and to the many individuals from academia and industry who helped in the conduct of this study. ; Peer reviewed ; Publisher PDF