Suchergebnisse

Nerve growth factor (NGF) is thought to play a key role in chronic pain felt by bladder pain syndrome/interstitial cystitis (BPS/IC) patients by activating its high affinity receptor tropomyosin-related kinase subtype A (Trk A). Whether this pathway is also involved in the aggravation of pain sensation during stress events was here investigated. The levels of plasmatic NGF were increased in rats submitted to Water Avoidance Stress test (WAS), compared to controls. The administration of the alpha1A adrenoceptors blocker silodosin prevented the increase of plasmatic NGF. Urinary NGF levels were also moderately increased in animals submitted to WAS. WAS increased pain behaviour score, lowered abdominal mechanical pain threshold and increase voiding bladder reflex activity. These changes were prevented by the administration of TrkA antagonist GW441756. These findings prompt the use of plasmatic NGF as diagnosis tool for chronic visceral painful conditions and opens therapeutic opportunities for TrkA receptors antagonist/NGF sequestration. ; The statements and opinions presented here reflect the author's view and neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained therein. This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No [777500]. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA. www.imi.europa.eu. www.imi-paincare.eu. This work was partially supported by PFD Research Foundation and ICA IC/PBS Research Grant.

NGC 7469 is a well-known luminous infrared galaxy, with a circumnuclear star formation ring ∼830 pc radius) surrounding a Seyfert 1 active galactic nucleus (AGN). Nuclear unresolved winds were previously detected in X-rays and ultraviolet, as well as an extended biconical outflow in infrared coronal lines. We search for extended outflows by measuring the kinematics of the Hβ and [O III] λ5007 optical emission lines, in data of the Very Large Telescope/Multi-unit Spectroscopic Explorer integral field spectrograph. We find evidence of two outflow kinematic regimes: One slower regime extending across most of the star formation (SF) ring-possibly driven by the massive SF-and a faster regime (with a maximum velocity of -715 km s-1), only observed in [O III], in the western region between the AGN and the massive star-forming regions of the ring, likely AGN-driven. This work shows a case where combined AGN/SF feedback can be effectively spatially resolved, opening up a promising path toward a deeper understanding of feedback processes in the central kiloparsec of AGN ; Support from CONACyT (Mexico) grant CB-2016-01-286316 is acknowledged. J.P.T.P. acknowledges DAIP-UGto (Mexico) for granted support (0173/2019). Y.A. acknowledges support from project PID2019-107408GB-C42 (Ministerio de Ciencia e Innovación, Spain). S.F.S. thanks the support of CONACYT grants CB-285080 and FC-2016-01- 1916, and funding from the PAPIIT-DGAPA-IN100519 (UNAM) project. L.G. was funded by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 839090. This work has been partially supported by the Spanish grant PGC2018-095317-B-C21 within the European Funds for Regional Development (FEDER). E.B acknowledges the support from Comunidad de Madrid through the Atracción de Talento grant 2017-T1/TIC-5213. This research has been partially funded by the Spanish State Research Agency (AEI) Project MDM-2017-0737 Unidad de Excelencia "María de Maeztu"- Centro de Astrobiología (INTA-CSIC)