Suchergebnisse

Chicory roots from hydroponic salad cultivation are an abundant food residue in Navarra (Spain) that are underutilized to date. Aiming at a holistic utilization of resources, we report here the first process using chicory root hydrolysate for the production of poly([R]-3-hydroxybutyrate) (PHB). The polymer can be used for packaging material made for the locally produced vegetables. In the first step, we developed a pre-treatment process to obtain a hydrolysate, which contained 34 g L-1 sugars and 0.7 g L-1 total Kjeldahl nitrogen. This hydrolysate was used as fermentation substrate for three PHB-producing strains. Cupriavidus necator DSM 428 reached a dry biomass concentration of 11.3 g L-1 with a PHB content of 66 % in dry mass within 5 days. C. necator DSM 531 yielded 3.5 g L-1 dry biomass containing 46 % PHB within the same period. C. necator DSM 545 was superior over the other two in that 14.0 g L-1 of biomass containing 78 % PHB after only 3 days were obtained. These results show that even within the same species, the productivities on natural substrates are very different. The produced polymers were extracted using chloroform, and several thermo-physical parameters are in good accordance with published data. Overall, our holistic approach and the encouraging results prove that chicory roots are a viable fermentation substrate for PHB-production. ; This work was conducted as a part of the LEAD-ERA Project CARBIO, which was financed by the Basque Goverment and co-financed by the European Regional Development Fund (ERDF) of the European Union.

BACKGROUND: The non-communicable diseases dental caries and periodontal diseases pose an enormous burden on mankind. The dental biofilm is a major biological determinant common to the development of both diseases, and they share common risk factors and social determinants, important for their prevention and control. The remit of this working group was to review the current state of knowledge on epidemiology, socio-behavioural aspects as well as plaque control with regard to dental caries and periodontal diseases. METHODS: Discussions were informed by three systematic reviews on (i) the global burden of dental caries and periodontitis; (ii) socio-behavioural aspects in the prevention and control of dental caries and periodontal diseases at an individual and population level; and (iii) mechanical and chemical plaque control in the simultaneous management of gingivitis and dental caries. This consensus report is based on the outcomes of these systematic reviews and on expert opinion of the participants. RESULTS: Key findings included the following: (i) prevalence and experience of dental caries has decreased in many regions in all age groups over the last three decades; however, not all societal groups have benefitted equally from this decline; (ii) although some studies have indicated a possible decline in periodontitis prevalence, there is insufficient evidence to conclude that prevalence has changed over recent decades; (iii) because of global population growth and increased tooth retention, the number of people affected by dental caries and periodontitis has grown substantially, increasing the total burden of these diseases globally (by 37% for untreated caries and by 67% for severe periodontitis) as estimated between 1990 and 2013, with high global economic impact; (iv) there is robust evidence for an association of low socio-economic status with a higher risk of having dental caries/caries experience and also with higher prevalence of periodontitis; (v) the most important behavioural factor, affecting both dental caries and periodontal diseases, is routinely performed oral hygiene with fluoride; (vi) population-based interventions address behavioural factors to control dental caries and periodontitis through legislation (antismoking, reduced sugar content in foods and drinks), restrictions (taxes on sugar and tobacco) guidelines and campaigns; however, their efficacy remains to be evaluated; (vii) psychological approaches aimed at changing behaviour may improve the effectiveness of oral health education; (viii) different preventive strategies have proven to be effective during the course of life; (ix) management of both dental caries and gingivitis relies heavily on efficient self-performed oral hygiene, that is toothbrushing with a fluoride-containing toothpaste and interdental cleaning; (x) professional tooth cleaning, oral hygiene instruction and motivation, dietary advice and fluoride application are effective in managing dental caries and gingivitis. CONCLUSION: The prevention and control of dental caries and periodontal diseases and the prevention of ultimate tooth loss is a lifelong commitment employing population- and individual-based interventions.

We present the Global Rapid Advanced Network Devoted to the Multi-messenger Addicts (GRANDMA). The network consists of 21 telescopes with both photometric and spectroscopic facilities. They are connected together thanks to a dedicated infrastructure. The network aims at coordinating the observations of large sky position estimates of transient events to enhance their follow-up and reduce the delay between the initial detection and optical confirmation. The GRANDMA programme mainly focuses on follow-up of gravitational-wave alerts to find and characterize the electromagnetic counterpart during the third observational campaign of the Advanced LIGO and Advanced Virgo detectors. But it allows for follow-up of any transient alerts involving neutrinos or gamma-ray bursts, even those with poor spatial localization. We present the different facilities, tools, and methods we developed for this network and show its efficiency using observations of LIGO/Virgo S190425z, a binary neutron star merger candidate.We furthermore report on allGRANDMAfollow-up observations performed during the first six months of the LIGO-Virgo observational campaign, and we derive constraints on the kilonova properties assuming that the events' locations were imaged by our telescopes. © 2019 The Author(s). ; Parts of this research were conducted by the Australian Research Council Centre of Excellence for Gravitational Wave Discovery (OzGrav), through project number CE170100004. EJH acknowledges support from a Australian Research Council DECRA Fellowship (DE170100891). AdUP and CCT acknowledge support from Ramon y Cajal fellowships RyC-2012-09975 and RyC-201209984 and the Spanish Ministry of Economy and Competitiveness through project AYA2017-89384-P. DAK acknowledges support from the Spanish research projectAYA2017-89384-P. MBacknowledges funding as `personal tecnico de apoyo' under fellowship number PTA2016-13192-I. MC is supported by the David and Ellen Lee Postdoctoral Fellowship at the California Institute of Technology. SA is supported by the CNES Postdoctoral Fellowship at Laboratoire AstroParticule et Cosmologie. SA, AC, CL, and RM acknowledge the financial support of the UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02). SA and NL acknowledge the financial support of the Programme National Hautes Energies (PNHE). DT acknowledges the financial support of the Chinese Academy of Sciences (CAS) PIFI post-doctoral fellowship program (program C). UBAI acknowledges support from the Ministry of Innovative Development through projects FA-Atech-2018-392 and VA-FAF-2-010. IRiS has been carried out thanks to the support of the OCEVU Labex (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02) funded by the 'Investissements d'Avenir' French government program. IRiS and T120 thank all the Observatoire de Haute-Provence staff for the permanent support. SB, NK, RN, and MV acknowledge the Shota Rustaveli National Science Foundation (SRNSF grant No 218070). TAROT has been built with the support of the Institut National des Sciences de l'Univers, CNRS,France. TAROT is funded by theCNESand thanks the help of the technical staff of the Observatoire de Haute Provence, OSU-Pytheas.