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AbstractThe Poisson ridge estimator (PRE) is a commonly used parameter estimation method to address multicollinearity in Poisson regression (PR). However, PRE shrinks the parameters toward zero, contradicting the real association. In such cases, PRE tends to become an insufficient solution for multicollinearity. In this work, we proposed a new estimator called the Poisson average maximum likelihood‐centered penalized estimator (PAMLPE), which shrinks the parameters toward the weighted average of the maximum likelihood estimators. We conducted a simulation study and case study to compare PAMLPE with existing estimators in terms of mean squared error (MSE) and predictive mean squared error (PMSE). These results suggest that PAMLPE can obtain smaller MSE and PMSE (i.e., more accurate estimates) than the Poisson ridge estimator, Poisson Liu estimator, and Poisson K‐L estimator when the true s have the same sign and small variation. Therefore, we recommend using PAMLPE to address multicollinearity in PR when the signs of the true s are known to be identical in advance.

BACKGROUND: In China, the pharmacy departments of most hospitals have changed their main focus from drug procurement and distribution to providing pharmaceutical care services. Various regions of China have successively implemented the pilot Chief Pharmacist System (CPS) to help improve pharmaceutical care services and rational drug use in hospitals. This study was designed to explore the perspectives of pharmacists and government officials on CPS, including the advantages and barriers to the successful implementation of CPS. METHODS: A qualitative study, based on semi-structured interviews, was conducted from October 1, 2018 to March 1, 2019. The interview data were gathered from 18 pharmacy staff and government representatives working in five distinct regions of China using purposive sampling. A thematic analysis approach and NVivo version 12 Plus was utilized to code and analysis of all interviews. RESULTS: Five broad themes were identified: the role of the chief pharmacist; their attitudes toward the CPS; the advantages and results of the CPS; the barriers toward CPS; and their suggestions toward CPS. Most of the participants believed that the chief pharmacist played a vital role in a hospital. Under CPS, the hospital pharmacy department pays more attention to prescription review, medication monitoring, and pharmaceutical consultation. However, an insufficient number of pharmacy personnel, unclear authority, and inadequate salaries were the main barriers to the implementation of the CPS. CONCLUSION: The attitudes of most of the participants were found to be positive toward CPS in China. The CPS can enhance the prestige of the hospital pharmacy department, improve the quality of hospital pharmaceutical care services, and promote rational drug use. Nevertheless, certain barriers highlighted in this study should be addressed promptly.