Suchergebnisse

Background: The rate of notifications of sexually transmissible infections (STIs) in Australians has increased dramatically, especially in those aged 16–30 years. This age bracket, typical of university students, is the most likely to report multiple sexual partners in the previous year. Individuals who have sex with multiple partners in a year have a significantly increased chance of contracting an STI, making them an important audience for sexual health promotion. This study aimed to determine how university sexual health promotion events can better reach this higher-risk subset of the population. Methods: Two anonymous cross-sectional surveys were used to understand current and ideal sexual health promotion events through the perspectives of student leaders (n = 62) and general university students (n = 502). Results: Students who had more than one sexual partner in the previous year (the higher-risk group) made up 22.7% of the students sampled. Higher-risk students differed substantially from lower-risk students in terms of preferred event types, incentives and topics to be covered, often prioritising those rarely used in current university sexual health events. Conclusion: While current university sexual health events include some features that align with student priorities, elements beyond sexual health information, such as social activity, alcohol incentives and on-site sexual health testing, can be helpful tools to attract students with higher numbers of sexual partners. ; This research was supported by an Australian Government Research Training Program (RTP) Scholarship

WKNSMSE (Workshop on North Sea stocks Management Strategy Evaluation) took place over two physical meetings (19-21 November 2018 and 26-28 February 2019, but at ICES HQ, Copenhagen) and several WebEx meetings, was chaired by José De Oliveira (UK) and included 30 participants from Denmark, Germany, Netherlands, Norway, Sweden, UK and the European Commission, and two reviewers from South African and New Zealand. The purpose of this work was to evaluate long-term management strategies for jointly-managed stocks in the North Sea (cod, haddock, whiting, saithe and autumn-spawning herring) between the European Union and Norway, following a request from EU-Norway. The first physical meeting provided an ICES interpretation of the EU-Norway request, agreed the specifications of the MSE, decided on the tools and approaches to use, and developed a work plan, while the second meeting (and subsequent follow-up WebEx meetings) discussed results, developed conclusions, ensured the minimum requirements for conducting MSEs (developed by WKGMSE2) were met, and finalised the report. ICES were tasked to find "optimal" combinations of harvest control rule parameters (F target and B trigger ) for management strategies with or without stability mechanisms (TAC constraints and banking and borrowing scenarios). "Optimal" combinations were defined as those combinations of F target and B trigger that simultaneously maximised long-term yield while being precautionary (long-term risk3≤5%). The request also asked for sensitivity tests once the management strategies were "optimised". The approach adopted for all stocks was to include the assessment and forecast in a full-feedback MSE simulation, and to condition the baseline operating model on the benchmarked ICES assessment. The one exception was haddock, where it was not possible to include TSA in the full-feedback simulation because it was too slow to converge and requires manual intervention; SAM was used instead as a reasonable approximation. The approach also considered alternative operating models to capture a broader range of uncertainties. Full-feedback simulations were computationally challenging and required the use of parallelisation and high-performance computing; it also meant that the time-frame for the work was extremely tight, and in some cases, analyses were restricted. Nonetheless, the work was completed for all stocks, and "optimal" combinations for most management strategies were found. There were some notable issues that arose through this suite of MSEs, including that some management strategies that were precautionary in the long-term could have unsavoury and avoidable features in the short term (depending on the management strategy), and that reference points estimated by EqSim were, in many cases, no longer found to be precautionary in the MSE.

Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-level assemblies of the Mus caroli and Mus pahari genomes. Together with the Mus musculus and Rattus norvegicus genomes, this set of rodent genomes is similar in divergence times to the Hominidae (human-chimpanzee-gorilla-orangutan). By comparing the evolutionary dynamics between the Muridae and Hominidae, we identified punctate events of chromosome reshuffling that shaped the ancestral karyotype of Mus musculus and Mus caroli between 3 and 6 million yr ago, but that are absent in the Hominidae. Hominidae show between four- and sevenfold lower rates of nucleotide change and feature turnover in both neutral and functional sequences, suggesting an underlying coherence to the Muridae acceleration. Our system of matched, high-quality genome assemblies revealed how specific classes of repeats can play lineage-specific roles in related species. Recent LINE activity has remodeled protein-coding loci to a greater extent across the Muridae than the Hominidae, with functional consequences at the species level such as reproductive isolation. Furthermore, we charted a Muridae-specific retrotransposon expansion at unprecedented resolution, revealing how a single nucleotide mutation transformed a specific SINE element into an active CTCF binding site carrier specifically in Mus caroli, which resulted in thousands of novel, species-specific CTCF binding sites. Our results show that the comparison of matched phylogenetic sets of genomes will be an increasingly powerful strategy for understanding mammalian biology. ; Wellcome Trust [WT108749/Z/15/Z, WT098051, WT202878/Z/16/Z, WT202878/B/16/Z]; National Human Genome Research Institute [U41HG007234]; Cancer Research UK [20412]; European Research Council [615584]; Biotechnology and Biological Sciences Research Council [BB/N02317X/a]; European Molecular Biology Laboratory; European Community's Seventh Framework Programme (FP7) [244356]; European Union's Seventh Framework Programme (FP7) [HEALTH-F4-2010-241504] ; 6 month embargo; published online: 21 March 2018 ; This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.