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Abstract
There is insufficient information about the progress and variability of multiple sclerosis (MS). Afferent visual pathways are an appropriate MS clinical model. Optical coherence tomography (OCT) allows to perform precise measurements of axonal tissue in the retinal nerve fibre layer (RNFL). Visual evoked potentials (VEP) provide information about the functional status of visual pathways. The aim of our study was to use OCT and VEP to evaluate MS patients with and without optic neuritis (ON) history and to determine relationships between functional and structural changes. The cross-sectional study included 76 relapsing-remitting MS patients and 28 healthy controls. The lowest mean VEP N75/P100 amplitude was found in ON affected eyes (8.16 mkV, SD = 4.60). However, it was observed that the mean amplitude in patients without ON (M = 9.86; SD = 4.63) was by 4.64 mkV lower than in controls (p < 0.001). Similarly, the mean P 100 latency in ON eyes was 9.26 ms longer than in eyes of patients without ON history (p < 0.01). RNFL in the temporal segment (RNFLT) was the thinnest in ON eyes, and even in patient eyes without ON, it was thinner than in controls. We found a significant positive correlation between RNFLT and mean N75/P100 amplitude in patients without ON (rs = 0.43; p < 0.001), and after ON (rs = 0.45; p < 0.001). Both in patients without ON (rs = -0.40; p < 0.001) and in ON eyes we found a significant negative correlation (rs = -0.55; p > 0.001) between RNFLT and mean P100 latency. In summary, we found that deterioration in the visual system was not associated with the clinical ON episode. Regardless of ON symptoms in history, there exists correlation between functional and structural changes.

Abstract
There are many factors that affect the well-being and health of employees and the productivity of organisations. The aim of this study was to determine the impact of the Metal Age training programme (MA®) on the well-being of office workers, including investigation of work ability, the stress-causing factors and role of leadership. The study was carried out using questions from four international questionnaires about stress, leadership, and work ability. The intervention group had a training course between the surveys using the ME® method. Several employee stress-causing factors were identified: bad relationship with their workmates was mentioned by 94% of workers; competitive and strenuous atmosphere — by more than 80%; psychological violence or bullying at the workplace by more than 80%, and more than 75% of employee's could not relax after work. Wellness and microclimate in the workplaces were on a relatively high level: the average rating of seven Kiva questions was 7.5. The respondent attitude after ME® did not change significantly. Latvian office workers displayed moderate and good work ability (Work Ability Index, WAI 34.5–38.6). The best work ability was shown in the age group from 20 to 49 (WAI 34.8–39.4); work ability decreased with age. The best correlation was observed between Work Ability Index and "get into situations, that invoke negative feelings" (r = 0.26) and "carrying out ongoing tasks because of other intervening or more urgent matters" (r = −0.24). After ME® the reaction to some stress-causing factors was improved.