Suchergebnisse

In this article, online sports betting is explored with the objective of critically examining the potential impact on problem gambling of the emerging product features and advertising techniques used to market it. First, the extent of the issue is assessed by reviewing the sports betting prevalence rates and its association with gambling disorders, acknowledging the methodological difficulties of an unambiguous identification of what exactly constitutes sports-related gambling today. Second, the main changes in the marketization of online betting products are outlined, with specific focus on the new situational and structural characteristics that such products present along with the convergence of online betting with other adjacent products. Third, some of the most prevalent advertising master narratives employed by the betting industry are introduced, and the implications for problem gamblers and minors are discussed.

Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene generating a great hope due to their outstanding specificity and potency. However, given their susceptibility to degradation and limited capacity to overcome biological barriers new delivery technologies had to be developed for them to reach their targets. This review aims at analyzing the historical seminal advances that shaped the development of the protein/peptide delivery field, along with the emerging technologies on the lead of the current landscape. Particularly, focus is made on technologies with a potential for transmucosal systemic delivery of protein/peptide drugs, followed by approaches for the delivery of antigens as new vaccination strategies, and formulations of biological drugs in oncology, with special emphasis on mAbs. Finally, a discussion of the key challenges the field is facing, along with an overview of prospective advances are provided. ; Spanish Ministry of Science, Innovation and Universities (Ref.SAF2017-86634-R) ; Government of Xunta de Galicia (Competitive Reference Groups, Ref: ED431C2017/09) ; MINECO- PCIN-2017-129/ AEI

Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene generating a great hope due to their outstanding specificity and potency. However, given their susceptibility to degradation and limited capacity to overcome biological barriers new delivery technologies had to be developed for them to reach their targets. This review aims at analyzing the historical seminal advances that shaped the development of the protein/peptide delivery field, along with the emerging technologies on the lead of the current landscape. Particularly, focus is made on technologies with a potential for transmucosal systemic delivery of protein/peptide drugs, followed by approaches for the delivery of antigens as new vaccination strategies, and formulations of biological drugs in oncology, with special emphasis on mAbs. Finally, a discussion of the key challenges the field is facing, along with an overview of prospective advances are provided ; This work was supported by the Spanish Ministry of Science, Innovation and Universities (Ref.SAF2017-86634-R), the government of Xunta de Galicia (Competitive Reference Groups, Ref:ED431C2017/09), and MINECO- PCIN-2017-129/ AEI, under the frame of EuroNanoMed III. M. Durán-Lobato acknowledges a postdoctoral contract granted by "VI Plan Propio" from the University of Seville (grant number USE-19533-Y), and Ana M. López-Estévez acknowledges a predoctoral FPU grant from the Spanish Ministry of Science, Innovation and Universities (grant number FPU18/00095) ; SI