Suchergebnisse

Along with the rapid development of industry and agriculture, growth of population, improvement of urbanization level, China has been confronted with increasingly serious deficiency and pollution of water resource. In order to deal with the challenge as well as reduce waste discharge, it is necessary to strengthen all the possible efforts in controlling water pollution. Therefore, the control and management of water pollution is of vital significance to the development of national economy and social society, which is worth doing research on academically and practically. Water pollution management, in a sense, results from the urbanization and cosmopolitanization process. In this aspect, the European countries have acquired a lot of successful experience in water pollution control, which provides plenty of useful knowledge and reference for China's ongoing efforts in water pollution control. This thesis, by taking a comparative analysis approach, looks into the European countries' experience of water pollution control, makes evaluations on their managerial strategies, system and methods. Then it reviews China's efforts on water pollution control, and analyzes the current situation of China's water management, especially the water pollution control system of Huaihe River Basin, and as a result puts forward suggestions to improve China's water pollution control system such as verification of property rights of water resources, enhancement of legal framework, investment and taxation policy preference, technological improvements, public participation and prevention measures. ; www.ima.kth.se

Atherosclerotic cardiovascular disease has a high mortality worldwide. Our lab previously purified a polysaccharide designated as CM1 with (1→4)-β-D-Glcp and (1→2)-α-D-Manp glycosyls as the backbone. In this study, we investigated the anti-atherosclerosis effect of CM1 and the underlying mechanisms of action in a low-density lipoprotein receptor knockout (LDLR((-/-)) mouse model. It was found that CM1 significantly decreased the formation of atherosclerotic plaques. Mechanistically, CM1 enhanced plasma level of apolipoprotein A-I and decreased the plasma levels of triglyceride, apolipoprotein B, and total cholesterol. In the absence of LDLR, CM1 elevated the expression of very low-density lipoprotein receptor for liver uptake of plasma apolipoprotein B-containing particles and reduced hepatic triglyceride synthesis by inhibiting sterol regulatory element binding protein 1c. CM1 improved lipids excretion by increasing the liver X receptor α/ATP-binding cassette G5 pathway in small intestine. CM1 reduced lipogenesis and lipolysis by inhibiting peroxisome proliferator-activated receptor γ and adipose triglyceride lipase in epididymal fat. Furthermore, CM1 improved lipid profile in C57BL/6J mice. Collectively, CM1 can modulate lipid metabolism by multiple pathways, contributing to reduced plasma lipid level and formation of atherosclerotic plaques in LDLR((−/−)) mice. This molecule could be explored as a potential compound for prevention and treatment of hyperlipidemia and atherosclerosis.

BACKGROUND: Cordyceps militaris is cultured widely as an edible mushroom and accumulating evidence in mice have demonstrated that the polysaccharides of Cordyceps species have lipid-lowering effects. However, lipid metabolism in mice is significantly different from that in humans, making a full understanding of the mechanisms at play critical. METHODS: After 5 months, the hamsters were weighed and sampled under anesthesia after overnight fasting. The lipid-lowering effect and mechanisms of the polysaccharide CM1 was investigated by cellular and molecular technologies. Furthermore, the effect of the polysaccharide CM1 (100 μg/mL) on inhibiting adipocyte differentiation was investigated in vitro. RESULTS: CM1, a polysaccharide from C. militaris, significantly decreased plasma total cholesterol, triglyceride and epididymal fat index in LDLR((+/−)) hamsters, which have a human-like lipid profile. After 5 months' administration, CM1 decreased the plasma level of apolipoprotein B48, modulated the expression of key genes and proteins in liver, small intestine, and epididymal fat. CM1 also inhibited preadipocyte differentiation in 3T3-L1 cells by downregulating the key genes involved in lipid droplet formation. CONCLUSIONS: The polysaccharide CM1 lowers lipid and adipocyte differentiation by several pathways, and it has potential applications for hyperlipidemia prevention. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12944-021-01606-6.